ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol COMT
Approved Name catechol-O-methyltransferase
Location 22q11.21
Position chr22:19929130-19957498, 1
External Links HGNC: 2228
Entrez Gene: 1312
Ensembl: ENSG00000093010
UCSC: uc002zqu.3
No. of Studies 29 (significant: 7; non-significant: 22; trend: 0)
Source Literature-origin; Mapped by Literature SNP; Mapped by CNV

Gene related studies (count: 29)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Qian Q, 2003 there was no overall evidence of association between COMT Val158-Met and DSM-IV ADHD Non-significant
Qian Q, 2007 Logistic Regression Analysis: P-value=0.941, OR=0.979, 95%CI=0.566-1.696. No evidence of association was seen. Non-significant
Sun H, 2013 No significant or Trend associated SNP was mapped in this gene. Non-significant
Tahir E, 2000 (a) No evidence of association between the COMT polymorphism and ADHD was found. Non-significant
Manor I, 2000 No association was observed between the COMT polymorphism and ADHD (or any of the DSM IV subtypes). Non-significant
Nyman ES, 2007 No evidence of association was seen. Non-significant
Payton A, 2001 there was no evidence of preferential transmission of any marker allele for the polymorphism examined in this study Non-significant
Pazvantoglu, O.,2013 The SNP in the genes COMT (rs4818) was not associated with ADHD Non-significant
Martinez-Levy, G. A.,2013 A logistic regression analysis showed that individuals with the COMT Met/Met genotype were more likely to belong to the hyperactive/impulsive-combined ADHD subgroup.However, replication in different or extended cohorts is necessary before drawing any definite conclusion. Moreover, the putative functional impact of the COMT genetic variation requires further investigation in terms of specific cognitive and behavioral aspects related to ADHD. Significant
Michaelovsky E, 2008 haplotype G-A-A P-value=0.036, OR=3.13, X2 (1)=4.38; haplotype A-G-G P-value=0.006, OR=0.12, X2 (1)=7.71; 8-SNP COMT-ARVCF haplotype G-T-C-A-insC-A-C-T P-value=0.017, OR 7.30, X2 (1)=5.74 ; 8-SNP COMT-ARVCF haplotype A-C-G-G-delC-G-C-T P-value=0.012, OR=0.13, X2 (1)=6.37; associated with ADHD Significant
Eisenberg J, 1999 No significant association was observed between COMT genotype and ADHD although there was an excess of the Val/Val genotype: HRR P-value=0.05, X2=5.98, df=2; there was a significant association of the COMT polymorphism and ADHD Significant
Halleland H, 2009 haplotype analyses: P-value=0.01 for 'GCGG', P-value=0.07 for 'ATCA', P-value=0.19 for 'ACCG'. One of the haplotype in this gene was associated with higher hyperactivity/impulsivity scores. Significant
Turic D, 2005(b) none of the SNPs or haplotypes showed evidence for association with ADHD Non-significant
Wang G. X., 2012 SNP rs4860 mapped to this gene showed no association with ADHD in this study. Non-significant
Palmason H, 2010 A allele (Met) of rs4680 was significantly over-transmitted to the children with ADHD Significant
Yatsuga, C.,2013 The occurrence of the COMT Val/Val genotype was significantly higher in children with ADHD (X2(1)=7.13, p<0.01). However, there was no significant difference in the Val/Val genotype according to disorder, and WISC and ADHD rating scale scores, after correcting for the interaction between disorder and COMT genotype. Significant
Biederman J, 2008 rs4680 showed overtransmission of the Met (A) allele to male offspring but not to female offspring; the pooled result showed a statistically significant gender effect for Val158Met in ADHD Significant
Brookes K, 2006 UNPHASED TDT P-value=0.137, global P-value=0.9, WHAP TDT P_sum P-value=0.752, no SNP with nominal P-value<0.05 located in this gene Non-significant
Bobb AJ, 2005 no polymorphism was associated with ADHD Non-significant
Bellgrove MA, 2005 rs4680 did not show any significant association in the extened family-based sample Non-significant
Barr CL, 1999 This study did not suggest a role for rs4680 (COMT_Val158Met) in susceptibility for ADHD Non-significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Das M, 2011 minimum UNPHASED P-value=0.71 for haplotype frequencies in the case-control analysis and minimum ETDT P-value=0.47, none of the haplotypes showed any significant association Non-significant
Cheuk DK, 2006(c) no significant association between the COMT Val158/108Met polymorphism and ADHD was found Non-significant
Carpentier, P. J., 2012 No significant association was found. Non-significant
Kirley A, 2002 No preferential transmission of alleles to ADHD children was observed Non-significant
Jiang SD, 2005 both TDT and HHRR analyses failed to detect preferential transmission of a COMT allele to the ADHD children; the data suggested that there was no association between ADHD and the COMT gene in the Chinese population Non-significant
Hawi, Z., 2012 This gene did not show significant association with ADHD. Non-significant
Hawi Z, 2000 (b) No association between COMT gene polymorphism and attention deficit hyperactivity disorder (ADHD) in this Irish sample Non-significant

Gene related SNPs (count: 33)

Literature-origin SNPs (count: 16)

LD-proxies (count: 17)


Gene related CNVs (count: 2)

Gene related other variant (count: 2)

Gene related regions (count: 0)

Gene related GO terms (count: 26)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 26)


Gene related KEGG pathways (count: 1)

Genes shared at least 5 GO terms with COMT (count: 10)

Genes shared at least 2 KEGG pathways with COMT (count: 0)

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Region: chr22:19929130..19957498 View in gBrowse
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