ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Jiang SD, 200516231731
Citation	Jiang S. D., Wu X. D., Zhang Y., Tang G. M., Qian Y. P. and Wang D. X. (2005) "No association between attention-deficit hyperactivity disorder and catechol-O-methyltransferase gene in Chinese." Yi Chuan Xue Bao, 32(8): 784-8.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	79 ADHD children and their parents
Predominant Ethnicity	Mongoloid
Population	China
Gender	57 male, 22 female
Age Group	Children/Adolescents : average age: 11.25 (SD=0.79)

Detail Info

Summary	Previous studies suggested that the catecholaminergic systems may be involved in the pathogenesis of attention-deficit hyperactivity disorder (ADHD). Since catechel-o-methyltransferase (COMT) is an enzyme involved in the degradation of catecholaminergic neurotransmitters of the dopaminergic and noradrenergic systems, it is possible that COMT may play a role in ADHD. To test this hypothesis, they used two family-based analyses, the transmission disequilibrium test (TDT) and the haplotype-based haplotype relative risk (HHRR), to examine the possible association between COMT gene and DSM-IV-diagnosed ADHD in a Chinese sample consisting of 79 ADHD probands and their parents. Both TDT and HHRR analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Their data suggested that there was no association between ADHD and COMT gene in the Chinese population.
Total Sample	The sample reported in this study consisted of 79 ADHD children and their parents. Among the ADHD children, 57 were male and 22 were female. The average age of these ADHD children was 11.25 years old (SD=0.79).
Sample Collection	The sample reported in this study consisted of 79 ADHD children and their parents.
Diagnosis Description	The cases met Diagnostic and Statistical Manual of Mental Disorders diagnoses of the combined subtype of ADHD. Each diagnosis was performed separately by at least two different child psychiatrists.
Technique	DNA was extracted from peripheral blood cells of these subjects by standard procedure. The G (val158/high activity) and A (Met158/low activity) alleles of the COMT gene were determined by a restriction fragment length polymorphism after PCR amplification and digestion with Nlalll, similar to a published method.
Analysis Method	Haplotype-based haplotype relative risk (HHRR) and transmission/disequilibrium test (TDT) analyses were performed to examine the possible association between ADHD and COMT gene.
Result Description	Both TDT (X²=1.03, df=1, P>0.05) and HHRR (X²=1.08, df=1, P>0.05) analyses failed to detect preferential transmission of a COMT allele to the ADHD children. Their data suggested that there was no association between ADHD and COMT gene in the Chinese population.

SNPs reported by this study (count: 1)

Genes reported by this study (count: 1)