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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Palmason H, 201019946713
Citation	Palmason H., Moser D., Sigmund J., Vogler C., Hanig S., Schneider A., Seitz C., Marcus A., Meyer J. and Freitag C. M. (2010) "Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant." J Neural Transm, 117(2): 259-67.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	166 clinically referred, unrelated children
Predominant Ethnicity	Caucasian
Population	Germany
Age Group	Children/Adolescents : 6-13 years

Detail Info

Summary	The aim of the present study was to assess the COMT Val158Met SNP as a risk factor for attention-deficit/hyperactivity disorder (ADHD), ADHD symptom severity and co-morbid conduct disorder (CD) in 166 children with ADHD. The main finding of the present study is that the Met allele of the COMT Val¹⁵⁸Met SNP was associated with ADHD and increased ADHD symptom severity. No association with co-morbid CD was observed. In addition, ADHD symptom severity and early adverse familial environment were positive predictors of lifetime CD. These findings support previous results implicating COMT in ADHD symptom severity and early adverse familial environment as risk factors for co-morbid CD, emphasizing the need for early intervention to prevent aggressive and maladaptive behavior progressing into CD, reducing the overall severity of the disease burden in children with ADHD.
Total Sample	166 clinically referred, unrelated children with ADHD aged 6-13 years old
Diagnosis Description	ADHD was diagnosed according to DSM-IV criteria by a standardized, structured child psychiatric interview Diagnostisches Interview bei psychischen Storungen im Kindes-und Jugendalter (Kinder-DIPS; Unnewehr et al. 1995) and a German Hyperkinetic Syndrome diagnosis checklist (DCL-HKS)
Technique	DNA was extracted according to the salting out procedure (Miller et al. 1988). The following primers were used in the polymerase chain reaction (PCR): 5'-ACT GTG GCT ACT CAG CTG TG-3' (forward) and 5'-CCT TTT TCC AGG TCT GAC AA-3' (reverse). The PCR reactions were done using an ABI GeneAmp 9700 cycler.
Analysis Method	Descriptive statistics were calculated by X²-test or analysis of variance as appropriate. Family based association with ADHD was assessed by UNPHASED, version 3.0.13 (Dudbridge 2008). The impact of COMT genotypes on ADHD symptom severity was assessed by linear regression analysis. The impact of COMT genotypes on co morbid lifetime CD was assessed by logistic regression analysis.
Result Description	The main finding of the present study is that the Met allele of the COMT Val¹⁵⁸Met SNP (rs4680) was associated with ADHD and increased ADHD symptom severity.

SNPs reported by this study (count: 1)

Genes reported by this study (count: 1)