ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Meta-analysis Report

Basic Info
Reference Gizer IR, 200919506906
Citation Gizer I. R., Ficks C. and Waldman I. D. (2009) "Candidate gene studies of ADHD: a meta-analytic review." Hum Genet, 126(1): 51-90.
Study Type Candidate association study
Summary The first aim of the present study was to conduct a comprehensive meta-analytic review of this literature to determine which candidate genes show consistent evidence of association with childhood ADHD across studies. The second aim was to test for heterogeneity across studies in the effect sizes for each candidate gene as its presence might suggest moderating variables that could explain inconsistent results. Significant associations were identified for several candidate genes including DAT1, DRD4, DRD5, 5HTT, HTR1B, and SNAP25. Further, significant heterogeneity was observed for the associations between ADHD and DAT1, DRD4, DRD5, DBH, ADRA2A, 5HTT, TPH2, MAOA, and SNAP25, suggesting that future studies should explore potential moderators of these associations (e.g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). They conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD.

Detail Info

SNPs reported by this study: 30

Genes reported by this study: 18