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Large-scale studies
- Genome-wide Association Studies of ADHD
- Genome-wide Linkage Studies of ADHD
- Genome-wide CNV Analyses of ADHD
- Meta-analysis Studies of ADHD
Data Summary
SNP Report
Name | rs3746544 dbSNP Ensembl | ||
---|---|---|---|
Location | chr20:10287084(Fwd) | ||
Variant Alleles | G/T | ||
Ancestral Allele | T | ||
Functional Annotation | 3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant. | ||
Consequence to Transcript | 3_prime_UTR_variant(ENST00000254976; ENST00000304886) intron_variant(ENST00000421143; ENST00000453544) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883) non_coding_exon_variant(ENST00000495883) |
||
No. of Studies | 16 (significant: 7; non-significant: 9; trend: 0) | ||
Source | Literature-origin |
Reference | Allele Change | Risk Allele | Statistical Values | Author Comments | Result of Statistical Analysis |
---|---|---|---|---|---|
Kustanovich V, 2003 | T/G | allelic TDT P-value=0.085, allelic TDT P-value=0.012 for pat...... allelic TDT P-value=0.085, allelic TDT P-value=0.012 for paternal transmission More... | TDT of individual alleles did not reach statistical signific...... TDT of individual alleles did not reach statistical significance but paternal transmissions show significant biased transmission of the T allele More... | Significant | |
Kim JW, 2007 | T/G | G | Combined TDT P-value=0.048 (OR=1.14); Single marker analysis...... Combined TDT P-value=0.048 (OR=1.14); Single marker analysis FBAT P-value=0.101; Exploratory analyses FBAT P-value=0.233 for co-morbid CD, P-value=0.012 for co-morbid MDD, P-value=0.082 for co-morbid BD More... | Combined and exploratory analysis showed evidence of signifi...... Combined and exploratory analysis showed evidence of significant association with ADHD and co-morbid MDD More... | Significant |
Sarkar, K., 2012 | T/G | allelic P-value=0.87, X2=0.0 for case-control, P...... allelic P-value=0.87, X2=0.0 for case-control, P-value=1, X2=0.0 for family-based; genotypic P-value=0.94, X2=0.11 for case-control, P-value=0.83, X2=0.36 for family-based; X2=3.89, TDT P-value=0.05, Relative risk (95% CI)=2.5 (1.3¨C4.9) More... | Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. rs3746544 'T' allele also showed mild over transmission from parents to probands, with a power of 67.6%, primarily due to a bias in maternal transmission. Comparative analysis of all published reports on rs3746544 also revealed statistically significant transmission of rs3746544 'T' allele. More... | Non-significant | |
Pazvantoglu, O.,2013 | G/T | genotype: (GG vs GT vs TT), chi-square tests, P-value=0.003,...... genotype: (GG vs GT vs TT), chi-square tests, P-value=0.003, X2=16.290; allele: chi-square tests, P-value=0.020, X2=7.833 among the groups; genotypic P-value=0.001, X2=13.049, df = 2 between the ADHD and HC groups, P-value=0.017 between the Non-ADHD and HC groups; allelic P-value= 0.009, X2=6.884, df=1 between the ADHD and HC groups; Presence of the G allele (GG + GT): P-value=0.605, X2=1.005, df=2 among the groups; Presence of the T allele (TT + GT): P-value=0.0001, X2=20.845, df=2 among the groups, P-value=0.0001, X2 = 16.206, df = 1 between both the ADHD and HC groups, P-value=0.001, X2 = 10.641, df = 1 between the Non-ADHD and HC groups More... | A significant difference was determined between the groups f...... A significant difference was determined between the groups for SNAP-25 (rs3746544). SNAP-25 (rs3746544) exhibited a significant difference between the ADHD and HC groups. T allele frequency was higher in parents with children with ADHD compared with the HC group, while G allele frequency was higher in the HC group. There were no differences in allele frequencies for SNAP-25 (rs3746544) between the ADHD and Non-ADHD groups, or the Non- ADHD and HC groups , after the Bonferroni correction. For SNAP-25 (rs3746544), while the G allele presence exhibited no significant difference among the groups, the presence of the T allele in the ADHD and non-ADHD groups was higher than that in the HC group. In contrast, there was no significant difference in terms of the presence of the G or T alleles between the ADHD and the Non-ADHD groups. More... | Significant | |
Hawi Z, 2005 | TDT P-value=0.18, X2=2.2, OR=1.5 for paternel tra...... TDT P-value=0.18, X2=2.2, OR=1.5 for paternel transmission; TDT P-value=0.6, X2=0.4, OR=0.8 for maternal transmission More... | a trend was seen for paternal transmission and no significan...... a trend was seen for paternal transmission and no significant association was observed for maternal transmission More... | Non-significant | ||
Nyman ES, 2007 | No available information. No available information. | No evidence of association was seen. No evidence of association was seen. | Non-significant | ||
Choi TK, 2007 | T/G | Pearson's chi-square test P-value=0.28, X2(1df)=1...... Pearson's chi-square test P-value=0.28, X2(1df)=1.15 for allele frequency, Pearson's chi-square test P-value=0.008, X2(2df)=9.57 for genotype frequency More... | there was an excess of the T allele but the difference was n...... there was an excess of the T allele but the difference was not statistically significant, and analysis of the distribution of genotypes detected a significant difference between cases and controls More... | Significant | |
Barr CL, 2000 (a) | T/G | TDT P-value=0.918 TDT P-value=0.918 | no significant evidence for biased transmission no significant evidence for biased transmission | Non-significant | |
Mill J, 2004 (b) | T/G | allelic TDT P-value=0.24, X2=1.35; HHRR P-value=0...... allelic TDT P-value=0.24, X2=1.35; HHRR P-value=0.26, X2=1.26; PDT P-value=0.23, X2=1.42, TRANSMIT P-value=0.06, X2=0.27 in parental samples. More... | the marker was not individually associated with ADHD in this...... the marker was not individually associated with ADHD in this sample More... | Non-significant | |
Ilott NE, 2010 | QTDT AT P-value=0.83, X2=0.05, df=1, QTDT AW P-va...... QTDT AT P-value=0.83, X2=0.05, df=1, QTDT AW P-value=0.67, X2=0.18, df=1 at age 2; QTDT AT P-value=0.21, X2=1.75, df=1, QTDT AW P-value=0.16, X2=1.98, df=1 at age 3 More... | no significant association no significant association | Non-significant | ||
Feng Y, 2005(b) | T/G | allelic TDT P-value=0.906, X2=0.014 in Irvine sam...... allelic TDT P-value=0.906, X2=0.014 in Irvine sample; allelic TDT P-value=0.813, X2=0.056 in Toronto sample More... | there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More... | Non-significant | |
Hawi, Z.,2013 | C allelic:T=162,NT=143,X2=1.184,P-value=0.2766,EP...... C allelic:T=162,NT=143,X2=1.184,P-value=0.2766,EP-value=0.97,OR=1.13 More... | TDT analyses of this SNP showed no significant nominal assoc...... TDT analyses of this SNP showed no significant nominal association with ADHD More... | Non-significant | ||
Galvez, J. M.,2013 | G/T | Allele P-value = 0.003 after Bonferroni correction; genotype...... Allele P-value = 0.003 after Bonferroni correction; genotype P-value = 0.002 after Bonferroni correction. More... | Significant association was observed Significant association was observed | Significant | |
Forero DA, 2009 | A/C | TDT P-value=0.028 (OR=1.15, 95% CI=1.01-1.31); Q statistic P...... TDT P-value=0.028 (OR=1.15, 95% CI=1.01-1.31); Q statistic P-value=0.86, I2= 0%. More... | Weak significant. Weak significant. | Significant | |
Brophy K, 2002 | T/G | MnlI | HHRR analysis: overall P-value=0.90, RR=1.01; paternal trans...... HHRR analysis: overall P-value=0.90, RR=1.01; paternal transmission P-value=0.59, RR=1.1; maternal transmission P-value=1.0, RR=1.0; TDT analysis: overall P-value=0.90, RR=1.06; paternal transmission P-value=1.0, RR=1.08; maternal transmission P-value=1.0, RR=1.0 More... | No significant evidence was found for biased transmission No significant evidence was found for biased transmission | Non-significant |
Gizer IR, 2009 | Meta-analysis model: Fixed: OR=1.15, 95% CI=1.01-1.31, two-t...... Meta-analysis model: Fixed: OR=1.15, 95% CI=1.01-1.31, two-tailed P-value=0.03; Q-statistic: P-value=0.847, I2=0 More... | significant but modest association significant but modest association | Significant |
Literature-origin genes (count: 1)

Approved Symbol | Approved Name | Location | No. of Studies (significant/non-significant/trend) ![]() |
---|---|---|---|
SNAP25 | synaptosomal-associated protein, 25kDa | 20p12-p11.2 | 21(16/5/0) |
Genes from other sources
(count: 1)

Approved Symbol | Approved Name | Location |
---|---|---|
SNAP25-AS1 | SNAP25 antisense RNA 1 | 20p12.2 |
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014