ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs3746544 dbSNP Ensembl
Location chr20:10287084(Fwd)
Variant Alleles G/T
Ancestral Allele T
Functional Annotation 3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript 3_prime_UTR_variant(ENST00000254976; ENST00000304886)
intron_variant(ENST00000421143; ENST00000453544)
nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883)
non_coding_exon_variant(ENST00000495883)
No. of Studies 16 (significant: 7; non-significant: 9; trend: 0)
Source Literature-origin

SNP related studies (count: 16)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Kustanovich V, 2003 T/G allelic TDT P-value=0.085, allelic TDT P-value=0.012 for pat...... allelic TDT P-value=0.085, allelic TDT P-value=0.012 for paternal transmission More... TDT of individual alleles did not reach statistical signific...... TDT of individual alleles did not reach statistical significance but paternal transmissions show significant biased transmission of the T allele More... Significant
Kim JW, 2007 T/G G Combined TDT P-value=0.048 (OR=1.14); Single marker analysis...... Combined TDT P-value=0.048 (OR=1.14); Single marker analysis FBAT P-value=0.101; Exploratory analyses FBAT P-value=0.233 for co-morbid CD, P-value=0.012 for co-morbid MDD, P-value=0.082 for co-morbid BD More... Combined and exploratory analysis showed evidence of signifi...... Combined and exploratory analysis showed evidence of significant association with ADHD and co-morbid MDD More... Significant
Sarkar, K., 2012 T/G allelic P-value=0.87, X2=0.0 for case-control, P...... allelic P-value=0.87, X2=0.0 for case-control, P-value=1, X2=0.0 for family-based; genotypic P-value=0.94, X2=0.11 for case-control, P-value=0.83, X2=0.36 for family-based; X2=3.89, TDT P-value=0.05, Relative risk (95% CI)=2.5 (1.3¨C4.9) More... Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. rs3746544 'T' allele also showed mild over transmission from parents to probands, with a power of 67.6%, primarily due to a bias in maternal transmission. Comparative analysis of all published reports on rs3746544 also revealed statistically significant transmission of rs3746544 'T' allele. More... Non-significant
Pazvantoglu, O.,2013 G/T genotype: (GG vs GT vs TT), chi-square tests, P-value=0.003,...... genotype: (GG vs GT vs TT), chi-square tests, P-value=0.003, X2=16.290; allele: chi-square tests, P-value=0.020, X2=7.833 among the groups; genotypic P-value=0.001, X2=13.049, df = 2 between the ADHD and HC groups, P-value=0.017 between the Non-ADHD and HC groups; allelic P-value= 0.009, X2=6.884, df=1 between the ADHD and HC groups; Presence of the G allele (GG + GT): P-value=0.605, X2=1.005, df=2 among the groups; Presence of the T allele (TT + GT): P-value=0.0001, X2=20.845, df=2 among the groups, P-value=0.0001, X2 = 16.206, df = 1 between both the ADHD and HC groups, P-value=0.001, X2 = 10.641, df = 1 between the Non-ADHD and HC groups More... A significant difference was determined between the groups f...... A significant difference was determined between the groups for SNAP-25 (rs3746544). SNAP-25 (rs3746544) exhibited a significant difference between the ADHD and HC groups. T allele frequency was higher in parents with children with ADHD compared with the HC group, while G allele frequency was higher in the HC group. There were no differences in allele frequencies for SNAP-25 (rs3746544) between the ADHD and Non-ADHD groups, or the Non- ADHD and HC groups , after the Bonferroni correction. For SNAP-25 (rs3746544), while the G allele presence exhibited no significant difference among the groups, the presence of the T allele in the ADHD and non-ADHD groups was higher than that in the HC group. In contrast, there was no significant difference in terms of the presence of the G or T alleles between the ADHD and the Non-ADHD groups. More... Significant
Hawi Z, 2005 TDT P-value=0.18, X2=2.2, OR=1.5 for paternel tra...... TDT P-value=0.18, X2=2.2, OR=1.5 for paternel transmission; TDT P-value=0.6, X2=0.4, OR=0.8 for maternal transmission More... a trend was seen for paternal transmission and no significan...... a trend was seen for paternal transmission and no significant association was observed for maternal transmission More... Non-significant
Nyman ES, 2007 No available information. No available information. No evidence of association was seen. No evidence of association was seen. Non-significant
Choi TK, 2007 T/G Pearson's chi-square test P-value=0.28, X2(1df)=1...... Pearson's chi-square test P-value=0.28, X2(1df)=1.15 for allele frequency, Pearson's chi-square test P-value=0.008, X2(2df)=9.57 for genotype frequency More... there was an excess of the T allele but the difference was n...... there was an excess of the T allele but the difference was not statistically significant, and analysis of the distribution of genotypes detected a significant difference between cases and controls More... Significant
Barr CL, 2000 (a) T/G TDT P-value=0.918 TDT P-value=0.918 no significant evidence for biased transmission no significant evidence for biased transmission Non-significant
Mill J, 2004 (b) T/G allelic TDT P-value=0.24, X2=1.35; HHRR P-value=0...... allelic TDT P-value=0.24, X2=1.35; HHRR P-value=0.26, X2=1.26; PDT P-value=0.23, X2=1.42, TRANSMIT P-value=0.06, X2=0.27 in parental samples. More... the marker was not individually associated with ADHD in this...... the marker was not individually associated with ADHD in this sample More... Non-significant
Ilott NE, 2010 QTDT AT P-value=0.83, X2=0.05, df=1, QTDT AW P-va...... QTDT AT P-value=0.83, X2=0.05, df=1, QTDT AW P-value=0.67, X2=0.18, df=1 at age 2; QTDT AT P-value=0.21, X2=1.75, df=1, QTDT AW P-value=0.16, X2=1.98, df=1 at age 3 More... no significant association no significant association Non-significant
Feng Y, 2005(b) T/G allelic TDT P-value=0.906, X2=0.014 in Irvine sam...... allelic TDT P-value=0.906, X2=0.014 in Irvine sample; allelic TDT P-value=0.813, X2=0.056 in Toronto sample More... there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More... Non-significant
Hawi, Z.,2013 C allelic:T=162,NT=143,X2=1.184,P-value=0.2766,EP...... C allelic:T=162,NT=143,X2=1.184,P-value=0.2766,EP-value=0.97,OR=1.13 More... TDT analyses of this SNP showed no significant nominal assoc...... TDT analyses of this SNP showed no significant nominal association with ADHD More... Non-significant
Galvez, J. M.,2013 G/T Allele P-value = 0.003 after Bonferroni correction; genotype...... Allele P-value = 0.003 after Bonferroni correction; genotype P-value = 0.002 after Bonferroni correction. More... Significant association was observed Significant association was observed Significant
Forero DA, 2009 A/C TDT P-value=0.028 (OR=1.15, 95% CI=1.01-1.31); Q statistic P...... TDT P-value=0.028 (OR=1.15, 95% CI=1.01-1.31); Q statistic P-value=0.86, I2= 0%. More... Weak significant. Weak significant. Significant
Brophy K, 2002 T/G MnlI HHRR analysis: overall P-value=0.90, RR=1.01; paternal trans...... HHRR analysis: overall P-value=0.90, RR=1.01; paternal transmission P-value=0.59, RR=1.1; maternal transmission P-value=1.0, RR=1.0; TDT analysis: overall P-value=0.90, RR=1.06; paternal transmission P-value=1.0, RR=1.08; maternal transmission P-value=1.0, RR=1.0 More... No significant evidence was found for biased transmission No significant evidence was found for biased transmission Non-significant
Gizer IR, 2009 Meta-analysis model: Fixed: OR=1.15, 95% CI=1.01-1.31, two-t...... Meta-analysis model: Fixed: OR=1.15, 95% CI=1.01-1.31, two-tailed P-value=0.03; Q-statistic: P-value=0.847, I2=0 More... significant but modest association significant but modest association Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 1)


SNPs in LD with rs3746544 (count: 0) View in gBrowse (chr20:10287084..10287084 )