ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs8636 dbSNP Ensembl
Location	Chr20:10287742(Fwd)
Variant Alleles	T/C
Ancestral Allele	C
Functional Annotation	3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000254976; ENST00000304886) intron_variant(ENST00000453544; ENST00000421143) nc_transcript_variant(ENST00000421143; ENST00000453544; ENST00000495883) non_coding_exon_variant(ENST00000495883)
No. of Studies	4 (significant: 2; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 4)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009			single SNP association analyses: Nominal P-value=0.032, Empi...... single SNP association analyses: Nominal P-value=0.032, Empirical P-value=0.491 for ADHD-I More...	non-significant for ADHD, but achieve nominal significance f...... non-significant for ADHD, but achieve nominal significance for ADHD-I More...	Significant
Sarkar, K., 2012	C/T		allelic P-value=0, X²=0.0 for case-control, P-va...... allelic P-value=0, X²=0.0 for case-control, P-value=0.75, X²=0.1 for family-based; genotypic P-value=0.84, X²=0.35 for case-control, P-value=0.77, X²=0.52 for family-based; X²=4.5, TDT P-value=0.03, Relative risk (95% CI)=2.6 (1.4¨C4.9) More...	Case-control analysis revealed lack of any significant diffe...... Case-control analysis revealed lack of any significant difference in allelic frequencies between ADHD probands, their parents and controls P>0.05. Family-based analyses showed over transmission of the derived allele 'C' of rs8636 to ADHD probands. More...	Significant
Feng Y, 2005(b)	T/C		allelic TDT P-value=1, X²=0 in Irvine sample; all...... allelic TDT P-value=1, X²=0 in Irvine sample; allelic TDT P-value=0.875, X²=0.025 in Toronto sample More...	there was no significant result both in the Toronto sample a...... there was no significant result both in the Toronto sample and the Irvine sample More...	Non-significant
Kim JW, 2007	C/T	T	Single marker analysis FBAT P-value=0.113; Exploratory analy...... Single marker analysis FBAT P-value=0.113; Exploratory analyses FBAT P-value=0.345 for co-morbid CD, P-value=0.114 for co-morbid MDD, P-value=0.105 for co-morbid BD More...	No association was found between ADHD or co-morbidities of A...... No association was found between ADHD or co-morbidities of ADHD and this SNP More...	Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SNAP25	synaptosomal-associated protein, 25kDa	20p12-p11.2	18(13/5/0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
SNAP25-AS1	SNAP25 antisense RNA 1	20p12.2

SNPs in LD with rs8636 (count: 2) View in gBrowse (chr20:10286313..10287742 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs4813925	intron_variant; nc_transcript_variant	1(1/0/0)	1.0[ASW]; 1.0[CEU]; 0.915[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 0.889[MEX]; 0.911[MKK]; 0.974[TSI]; 0.924[YRI]
rs3746544	3_prime_UTR_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	13(5/8/0)	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[MEX]; 0.974[TSI]

SNP Report

Literature-origin genes (count: 1)

Genes from other sources (count: 1)

Literature-origin SNPs (count: 2)

LD-proxies (count: 0)