Forero DA, 200919721846
||Forero D. A., Arboleda G. H., Vasquez R. and Arboleda H. (2009) "Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants." J Psychiatry Neurosci, 34(5): 361-6.
||Candidate association study
||The objective of the present study was to carry out a meta-analysis for 8 common variants located in 5 top candidate genes for ADHD (BDNF, HTR1B, SLC6A2, SLC6A4 and SNAP25). They performed a search for published genetic association studies that analyzed the candidate polymorphisms in different populations, and then applied state-of-the-art meta-analytical procedures to obtain pooled odds ratios (ORs) and to evaluate potential basis of heterogeneity. 75 genetic association studies were included in these meta-analyses. It turned out a major part of the previously postulated associations were nonconsistent in the pooled odds ratios. A weak significant association with a single nucleotide polymorphism (SNP) located in the 3'UTR region of the SNAP25 gene was observed. Limitations of this study include the retrospective nature of the meta-analysis with the incorporation of study-level data from published articles. Previously proposed cumulative associations with common polymorphisms in SLC6A4 and HTR1B genes were not supported.
SNPs reported by this study: 7