ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Meta-analysis Report

Basic Info
Reference Forero DA, 200919721846
Citation Forero D. A., Arboleda G. H., Vasquez R. and Arboleda H. (2009) "Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants." J Psychiatry Neurosci, 34(5): 361-6.
Study Type Candidate association study
Summary The objective of the present study was to carry out a meta-analysis for 8 common variants located in 5 top candidate genes for ADHD (BDNF, HTR1B, SLC6A2, SLC6A4 and SNAP25). They performed a search for published genetic association studies that analyzed the candidate polymorphisms in different populations, and then applied state-of-the-art meta-analytical procedures to obtain pooled odds ratios (ORs) and to evaluate potential basis of heterogeneity. 75 genetic association studies were included in these meta-analyses. It turned out a major part of the previously postulated associations were nonconsistent in the pooled odds ratios. A weak significant association with a single nucleotide polymorphism (SNP) located in the 3'UTR region of the SNAP25 gene was observed. Limitations of this study include the retrospective nature of the meta-analysis with the incorporation of study-level data from published articles. Previously proposed cumulative associations with common polymorphisms in SLC6A4 and HTR1B genes were not supported.

Detail Info

SNPs reported by this study: 7