ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

SNP Report

Basic Info
Name rs6265 dbSNP Ensembl
Location chr11:27679916(Fwd)
Variant Alleles C/T
Ancestral Allele C
Functional Annotation 3_prime_UTR_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant.
Polyphen Annotation: probably damaging(ENST00000314915; ENST00000356660; ENST00000395978; ENST00000395980; ENST00000395981; ENST00000395983; ENST00000395986; ENST00000418212; ENST00000420794; ENST00000438929; ENST00000439476; ENST00000525528; ENST00000525950; ENST00000530861; ENST00000532997; ENST00000533131; ENST00000533246)
SIFT Annotation: tolerated(ENST00000314915; ENST00000356660; ENST00000395978; ENST00000395980; ENST00000395981; ENST00000395983; ENST00000395986; ENST00000418212; ENST00000420794; ENST00000438929; ENST00000439476; ENST00000525528; ENST00000525950; ENST00000530861; ENST00000532997; ENST00000533131; ENST00000533246)
Consequence to Transcript 3_prime_UTR_variant(ENST00000530786)
downstream_gene_variant(ENST00000532965)
intron_variant(ENST00000530313)
missense_variant(ENST00000314915; ENST00000356660; ENST00000395978; ENST00000395980; ENST00000395981; ENST00000395983; ENST00000395986; ENST00000418212; ENST00000420794; ENST00000438929; ENST00000439476; ENST00000525528; ENST00000525950; ENST00000530861; ENST00000532997; ENST00000533131; ENST00000533246)
nc_transcript_variant(ENST00000499008; ENST00000499568; ENST00000500662; ENST00000501176; ENST00000502161; ENST00000530313; ENST00000530686; ENST00000584049)
NMD_transcript_variant(ENST00000530786)
non_coding_exon_variant(ENST00000499008; ENST00000499568; ENST00000500662; ENST00000501176; ENST00000502161; ENST00000530686; ENST00000584049)
No. of Studies 13 (significant: 3; non-significant: 10; trend: 0)
Source Literature-origin

SNP related studies (count: 13)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Forero DA, 2009 A/G Not significant for the total samples. Not significant for the total samples. Non-significant
Friedel S, 2005 G/A genotypic Cochran-Armitage trend test P-value>0.2 genotypic Cochran-Armitage trend test P-value>0.2 no significant difference was observed no significant difference was observed Non-significant
Kent L, 2005 Val/Met TDT P-value=0.02, OR=1.61 for parental alleles; TDT P-value=...... TDT P-value=0.02, OR=1.61 for parental alleles; TDT P-value=1.00, OR=1.00 for maternal alleles; TDT P-value=0.0005, OR=3.2 for paternal alleles More... there was significant overtransmission of the Val allele for...... there was significant overtransmission of the Val allele for the whole sample and separate parental transmissions; maternal transmissions alone demonstrated no bias but there was highly significant overtransmission of the Val allele from fathers More... Significant
Sanchez-Mora C, 2010 G>A meta-analysis P-value=0.86, OR=0.99 for dominat model with f...... meta-analysis P-value=0.86, OR=0.99 for dominat model with fixed effects; fixed-effects model P-value=0.95, OR=0.99 for combined subtype, P-value=0.24, OR=0.86 for inattentive subtype, P-value=0.51, OR=0.93 for females, P-value=0.72, OR=1.03 for males More... showed a lack of a statistically significant effect on adult...... showed a lack of a statistically significant effect on adulthood ADHD More... Non-significant
Gizer IR, 2009 Meta-analysis model: Fixed: OR=1.01, 95% CI=0.91-1.12, P-val...... Meta-analysis model: Fixed: OR=1.01, 95% CI=0.91-1.12, P-value=0.406; Q-statistic: P-value=0.504, I2=0 More... no evidence to suggest an association between this polymorph...... no evidence to suggest an association between this polymorphisms and ADHD More... Non-significant
Schimmelmann BG, 2007 Val/Met allelic TDT P-value=1 in parental, paternal and maternal tra...... allelic TDT P-value=1 in parental, paternal and maternal transmission; PO-LRT P-value=0.47 between the transmission difference of fathers and mothers More... there was no significant over-transmission of the common Val...... there was no significant over-transmission of the common Val66 allele neither from all parents nor from fathers or mothers separately; paternal and maternal transmissions were not significantly different More... Non-significant
Aureli A, 2010 G/A Fisher's exact test P-value=0.0009, X2=11.54, OR=...... Fisher's exact test P-value=0.0009, X2=11.54, OR=3.44 for 196G allele, Pearson's chi-squared test P-value=0.003, X2=11.65, OR=7.04 for the G/A genotype More... 196G allele was statistically significant for the ADHD group...... 196G allele was statistically significant for the ADHD group and the G/A genotype was more frequent in both ADHD and ID patients compared to controls More... Significant
Lanktree M, 2008 A(M):G(V) X2=4.41, P-value=0.036 in the family-based sample...... X2=4.41, P-value=0.036 in the family-based sample; X2=2.31, P-value=0.13, OR=1.47 in the case-control sample; X2=6.71, P-value=0.0096, OR=1.65 in the combined samples More... showed marginal significance in the family-based sample, and...... showed marginal significance in the family-based sample, and showed association in the combined samples More... Significant
Lee J, 2007 A/G A Allelic TDT P-value=0.627 for all transmissions, P-value=0.7...... Allelic TDT P-value=0.627 for all transmissions, P-value=0.777 for paternal transmissions, P-value=0.655 for maternal transmissions; quantitative analysis FBAT smallest P-value=0.372 for Teacher rated hyperactivity/impulsivity More... No significant evidence of biased transmission or relationsh...... No significant evidence of biased transmission or relationship between this allele and the two ADHD symptom dimensions or short-term and working memory scores More... Non-significant
Cho SC, 2010(a) allelic P-value=0.525, X2 (1df)=0.405, genotypic ...... allelic P-value=0.525, X2 (1df)=0.405, genotypic P-value=0.735, X2 (2df)=0.615 in boys; allelic P-value=0.347, X2 (1df)=0.886, genotypic P-value=0.578, X2 (2df)=1.234 in girls; TDT P-value=0.059, X2 (df=1)=3.56 More... a trend toward the preferential transmission of the A allele...... a trend toward the preferential transmission of the A allele in girls More... Non-significant
Tzang RF, 2013 Uncorrected TDT P-value=0.637 Uncorrected TDT P-value=0.637 SNP indicated no significant association with ADHD SNP indicated no significant association with ADHD Non-significant
Thakur G. A., 2012 A/G A FBAT: Z=-0.79, P=0.43, effect size=0.07 FBAT: Z=-0.79, P=0.43, effect size=0.07 No association with ADHD was found. No association with ADHD was found. Non-significant
Xu X, 2007(b) UK sample: TDT P-value=0.666, HHRR P-value=0.668, TRANSMIT P...... UK sample: TDT P-value=0.666, HHRR P-value=0.668, TRANSMIT P-value=0.196; Taiwanese sample: TDT P-value=0.788, HHRR P-value=0.789, TRANSMIT P-value=0.835 More... No significant preferential transmission of any allele was f...... No significant preferential transmission of any allele was found More... Non-significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Genes from other sources Help (count: 1)


SNPs in LD with rs6265 (count: 19) View in gBrowse (chr11:27541623..27733858 )
The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r2>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 19)