ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs11030104 dbSNP Ensembl
Location	Chr11:27684517(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000530786) downstream_gene_variant(ENST00000532965; ENST00000530313) intron_variant(ENST00000395986; ENST00000500662; ENST00000499008; ENST00000530686; ENST00000499568; ENST00000502161; ENST00000501176; ENST00000395978; ENST00000533131; ENST00000395981; ENST00000395983; ENST00000532997; ENST00000418212; ENST00000530786; ENST00000530861; ENST00000525950; ENST00000533246; ENST00000584049; ENST00000438929; ENST00000356660; ENST00000314915; ENST00000395980; ENST00000420794) nc_transcript_variant(ENST00000530686; ENST00000499008; ENST00000500662; ENST00000499568; ENST00000502161; ENST00000501176; ENST00000584049) upstream_gene_variant(ENST00000439476; ENST00000525528; ENST00000501663; ENST00000528035)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lee J, 2007	G/A	G	Allelic TDT P-value=0.464 for all transmissions, P-value=0.4...... Allelic TDT P-value=0.464 for all transmissions, P-value=0.484 for paternal transmissions, P-value=0.655 for maternal transmissions; quantitative analysis FBAT smallest P-value=0.208 for Parent rated inattention More...	No significant evidence of biased transmission or relationsh...... No significant evidence of biased transmission or relationship between this allele and the two ADHD symptom dimensions or short-term and working memory scores More...	Non-significant
Lanktree M, 2008	G:A		X²=4.79, P-value=0.029 in the family-based sample...... X²=4.79, P-value=0.029 in the family-based sample; X²=2.51, P-value=0.11, OR=1.48 in the case-control sample; X²=6.93, P-value=0.0085, OR=1.66 in the combined samples More...	showed marginal significance in the family-based sample, and...... showed marginal significance in the family-based sample, and showed association in the combined samples More...	Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
BDNF	brain-derived neurotrophic factor	11p14.1	14(8/6/0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
BDNF-AS1	BDNF antisense RNA 1 (non-protein coding)	11p14.1

SNPs in LD with rs11030104 (count: 39) View in gBrowse (chr11:27541623..27749725 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 5)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs7103411	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	2(2/0/0)	0.89[CEU]; 1.0[CHB]; 0.976[CHD]; 0.916[GIH]; 1.0[JPT]; 1.0[MEX]; 0.942[TSI]
rs6265	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant	12(3/9/0)	0.941[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 1.0[MEX]; 0.97[TSI]
rs10767664	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)	0.877[CEU]; 0.95[CHB]; 1.0[JPT]
rs1491850	intron_variant; nc_transcript_variant	1(1/0/0)	0.836[CHD]; 1.0[JPT]
rs2049045	NMD_transcript_variant; intron_variant; nc_transcript_variant	1(1/0/0)	0.941[CEU]

LD-proxies (count: 34)

rs_ID	Functional Annotation	r²[population]
rs1906654	intron_variant; nc_transcript_variant	0.842[CEU]
rs7116850	intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[MEX]
rs6484312	downstream_gene_variant; intron_variant; nc_transcript_variant	0.889[CEU]
rs4923461	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.913[GIH]; 0.848[JPT]; 1.0[MEX]; 0.94[TSI]
rs988748	intron_variant; nc_transcript_variant; upstream_gene_variant	0.889[CEU]; 0.952[CHB]; 1.0[JPT]
rs4923457	intron_variant; nc_transcript_variant	1.0[CEU]; 0.848[JPT]
rs1114029	intron_variant; nc_transcript_variant	0.843[CEU]
rs1013442	intron_variant; nc_transcript_variant	0.843[CEU]
rs7103873	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.817[CHB]
rs988712	intron_variant; nc_transcript_variant	1.0[ASW]; 0.843[CEU]
rs925947	intron_variant; nc_transcript_variant	1.0[CEU]; 0.95[CHB]; 0.949[JPT]
rs7934165	intron_variant; nc_transcript_variant	0.824[CHD]
rs4923460	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.877[GIH]; 0.848[JPT]; 0.909[TSI]
rs10734394	intron_variant; nc_transcript_variant	0.843[CEU]
rs7124596	intron_variant; nc_transcript_variant	0.843[CEU]
rs10767665	intron_variant; nc_transcript_variant	0.801[CHD]
rs1488830	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.825[GIH]; 1.0[MEX]; 0.94[TSI]
rs901925	downstream_gene_variant; intron_variant; nc_transcript_variant	0.821[CEU]
rs12419948	intron_variant; nc_transcript_variant	1.0[CEU]; 0.865[CHB]; 0.95[JPT]
rs10767649	intron_variant; nc_transcript_variant	0.843[CEU]
rs6484313	downstream_gene_variant; intron_variant; nc_transcript_variant	0.841[CEU]
rs1488829	intron_variant; nc_transcript_variant	0.843[CEU]
rs10501087	intron_variant; nc_transcript_variant	0.843[ASW]; 1.0[CEU]; 0.865[CHB]; 0.929[CHD]; 0.97[GIH]; 0.95[JPT]; 1.0[MEX]; 1.0[TSI]
rs6484320	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.89[CEU]; 1.0[CHB]; 1.0[JPT]
rs4922788	intron_variant; nc_transcript_variant	0.843[CEU]
rs10742178	intron_variant; nc_transcript_variant	0.843[CEU]
rs879048	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 0.825[GIH]; 1.0[MEX]; 0.94[TSI]
rs11030084	intron_variant; nc_transcript_variant	0.935[CEU]; 0.839[JPT]
rs4074134	intron_variant; nc_transcript_variant	1.0[CEU]; 0.883[GIH]; 0.848[JPT]; 1.0[MEX]; 0.94[TSI]
rs1304100	intron_variant; nc_transcript_variant	0.876[CEU]
rs2030323	intron_variant; nc_transcript_variant	0.89[CEU]; 0.952[CHB]; 1.0[JPT]
rs2101467	intron_variant; nc_transcript_variant; upstream_gene_variant	0.843[CEU]
rs16917237	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.976[CHD]; 1.0[GIH]; 1.0[JPT]; 0.884[LWK]; 1.0[MEX]; 0.882[MKK]; 1.0[TSI]
rs10835195	intron_variant; nc_transcript_variant	0.843[CEU]