ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol BDNF
Approved Name brain-derived neurotrophic factor
Name Alias neurotrophin
Location 11p14.1
Position chr11:27676440-27743605, -
External Links HGNC: 1033
Entrez Gene: 627
Ensembl: ENSG00000176697
UCSC: uc001mrm.2
No. of Studies 14 (significant: 8; non-significant: 6; trend: 0)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 14)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Aureli A, 2010 two investigated BDNF SNPs were siginificantly associated with ADHD Significant
Cho SC, 2010(a) The T-G-G haplotype was significantly less frequent and A-G-G was more frequent in girls with ADHD than in control girls, haplotype specific T-G-G P-value=0.005, haplotype specific A-G-G P-value=0.048, haplotype global P-value=0.027; AA genotype of rs 11030101 was significantly associated with ADHD only in girls, P-value=0.024, OR=3.00 Significant
Thakur G. A., 2012 SNP rs6265 mapped to this gene showed no significant association with ADHD in this study. Non-significant
Lanktree M, 2008 haplotype A-G-A-G-T P-value=0.0086, X2 =6.90 in the family-based sample, P-value=0.025, X2 =5.04, OR=1.47 in the combined samples; haplotype G-A-G-C-C P-value=0.0054, X2 =7.75, OR=0.46 in the case-control sample, P-value=0.0013, X2 =10.37, OR=0.50 in the combined samples; allelic and haplotype association was found Significant
Oades RD, 2008 3 SNPs showed significant association Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Sanchez-Mora C, 2010 no association between the p.Val66Met polymorphism and ADHD Non-significant
Brookes K, 2006 UNPHASED TDT P-value=0.165, global P-value=0.888, WHAP TDT P_sum P-value=0.534, no SNP with nominal P-value<0.05 located in this gene Non-significant
Kent L, 2005 evidence for preferential transmission of the valine (G) allele with a strong paternal effect supported the association between BDNF and ADHD Significant
Friedel S, 2005 revealed no significant differences in genotype or allele distributions Non-significant
Ribases M, 2008 1 SNP showed significant association with both adulthood and childhood ADHD; 1 SNP showed significant association with childhood ADHD Significant
Lee J, 2007 Haplotype TRANSMIT Analysis: Global P-value=0.096 on 3 df for haplotypes with frequencies>10%; P-value=0.021 for haplotype AGG (frequency 2.2%) | quantitative analyses of haplotype: smallest P-value=0.008 for AGG in Parent rated hyperactivity/impulsivity. Uncommon haplotype, A-G-G (frequency 2.2%), demonstrated a significant association with ADHD in categorical and quantitative analyses. However, the number of transmission for this haplotype was considered too low to provide a definitive result. Significant
Schimmelmann BG, 2007 the result did not support for an involvement of the Val66 allele of the Val66Met polymorphism of BDNF in the pathogenesis of ADHD in this sample Non-significant
Xu X, 2007(b) Haplotype test for Val66/270T: TDT P-value=0.032, HHRR P-value=0.012, TRANSMIT P-value=0.014 for Taiwanese samples; TDT P-value=0.016, HHRR P-value=0.013, TRANSMIT P-value=0.07 for pooled samples. Haplotype analyses found evidence for decreased transmission of the Val66/270T haplotype in the Taiwanese sample and the pooled Taiwan/UK sample. Significant

Gene related SNPs (count: 30)

Literature-origin SNPs (count: 13)

LD-proxies (count: 17)

Gene related CNVs (count: 0)

Gene related other variant (count: 1)

Gene related regions (count: 0)

Gene related GO terms (count: 37)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 3)

Genes shared at least 5 GO terms with BDNF (count: 4)

Genes shared at least 2 KEGG pathways with BDNF (count: 11)

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Region: chr11:27676440..27743605 View in gBrowse
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