ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Other Variant Report

Basic Info
Name BDNF_C270T
Type point mutation
Location 5' UTR
Related Gene BDNF
No. of Study 3 (significant: 2; non-significant 1; trend: 0)

Variant related studies (count: 3)
Reference Allele Change Risk Allele Statistical Values Author Comments Result of Statistical Analysis
Aureli A, 2010 C/T Fisher's exact test P-value=0.02, X2=5.2, OR=3.86...... Fisher's exact test P-value=0.02, X2=5.2, OR=3.86 for C allele, Pearson's chi-squared test P-value=0.001, X2=11.96, OR=16.3 for the C/C genotype More... both C allele and the C/C genotype was more frequent in both...... both C allele and the C/C genotype was more frequent in both ADHD and ID groups compared with the controls More... Significant
Friedel S, 2005 C/T genotypic Cochran-Armitage trend test P-value>0.2 genotypic Cochran-Armitage trend test P-value>0.2 no significant difference was observed no significant difference was observed Non-significant
Xu X, 2007(b) C/T UK sample: TDT P-value=0.176, HHRR P-value=0.180, TRANSMIT P...... UK sample: TDT P-value=0.176, HHRR P-value=0.180, TRANSMIT P-value=0.686; Taiwanese sample: TDT P-value=0.009, HHRR P-value=0.008, TRANSMIT P-value=0.008; Combined sample: TDT P-value=0.007, HHRR P-value=0.007, TRANSMIT P-value=0.037 More... there was evidence of increased transmission of the C allele...... there was evidence of increased transmission of the C allele in the Taiwanese sample and combined sample. More... Significant