ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Cho SC, 2010(a)21253413
Citation	Cho S. C., Kim H. W., Kim B. N., Kim J. W., Shin M. S., Chung S., Cho D. Y., Jung S. W., Yoo H. J., Chung I. W., Chung U. S. and Son J. W. (2010) "Gender-specific association of the brain-derived neurotrophic factor gene with attention-deficit/hyperactivity disorder." Psychiatry Investig, 7(4): 285-90.
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	202 cases, 159 controls, 151 trios
Predominant Ethnicity	Mongoloid
Population	Korea
Gender	174 ADHD subjects and 111 normal controls were boys
Age Group	Children/Adolescents : mean age=9.0,SD=2.5

Detail Info

Summary	The study aimed to explore the relationships between ADHD and BDNF gene polymorphism. They conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test on 151 trios, and compared the results of a continuous performance test (CPT) according to the genotype of the three single nucleotide polymorphisms (rs11030101, rs6265, rs16917204) in the BDNF gene. In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls (P-value=0.024, odds ratio=3.00). The T-G-G haplotype was significantly less frequent (P-value=0.005) and A-G-G was more frequent (P-value=0.048) in girls with ADHD than in control girls (global P-value=0.027). A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype (P-value=0.026) and an interaction effect of the rs11030101 genotype and gender (P-value=0.032) in ADHD probands. These results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.
Total Sample	This study included 202 subjects with ADHD (mean=9.0,SD=2.5 years) and 159 normal children (mean=9.0,SD=2.7 years) for the case-control analysis. The family-based analysis included 151 trios consisting of an affected subject and his or her biological father and mother.
Sample Collection	ethnically Korean
Diagnosis Description	All subjects with ADHD met the following inclusion criteria: 1)DSM-IV diagnosis of ADHD; 2)above the 90th percentile in the ADHD Rating Scale-IV (ARS); 3)T-scores greater than 60 on the attention problems profile of the Child Behavior Checklist (CBCL); and 4)intelligence quotient (IQ) higher than 71 on the Korean Educational Developmental Institute's Wechsler Intelligence Scale for Children (KEDI-WISC). Subjects were excluded if they had one or more of the following: 1)past and/or current history of neurological disorder, including seizure disorder or brain damage; and 2)presence of comorbid psychosis, Tourette's, bipolar, communication, learning, or pervasive developmental disorder.
Technique	The detection of a single nucleotide polymorphism (SNP) was based on analysis of primer extension products generated from previously amplified genomic DNA using a chip-based MALDI-TOF mass spectrometry platform. All primers in the PCR and hME reactions were designed using Assay Designer 3.1.
Analysis Method	each individual polymorphism and haplotype were tested using the standard transmission disequilibrium test (TDT) method in Haploview or SNP-Alyzer software ver 7.0. Multivariate analysis of variance (MANOVA) was computed to examine the effect of BDNF genotype and gender on the result of the CPT in SPSS.
Result Description	In the case-control analysis, the AA genotype of the BDNF rs11030101 polymorphism was significantly associated with ADHD only in girls. The T-G-G haplotype was significantly less frequent and A-G-G was more frequent in girls with ADHD than in control girls. A multivariate analysis of variance for commission errors on the CPT showed a significant main effect for the rs11030101 genotype and an interaction effect of the rs11030101 genotype and gender in ADHD probands. The results provide preliminary evidence for a gender-specific association between BDNF and ADHD in the Korean population.

SNPs reported by this study (count: 3)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs11030101			allelic P-value=0.96, X² (1df)=0, genotypic P-value=0.667, X² (2df)=0.81 in boys; allelic P-value=0.015, X² (1df)=5.87, genotypic P-value=0.035 in girls	the A allele and AA genotype were significantly higher in gi...... the A allele and AA genotype were significantly higher in girls with ADHD than in control girls More...	Significant
rs6265			allelic P-value=0.525, X² (1df)=0.405, genotypic P-value=0.735, X² (2df)=0.615 in boys; allelic P-value=0.347, X² (1df)=0.886, genotypic P-value=0.578, X² (2df)=1.234 in girls; TDT P-value=0.059, X² (df=1)=3.56	a trend toward the preferential transmission of the A allele...... a trend toward the preferential transmission of the A allele in girls More...	Non-significant
rs16917204			allelic P-value=0.726, X² (1df)=0.123, genotypic P-value=0.913, X² (2df)=0.181 in boys; allelic P-value=0.524, X² (1df)=0.407, genotypic P-value=0.766, X² (2df)=0.533 in girls	no significant association no significant association	Non-significant

Genes reported by this study (count: 1)