ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAPK7
Previous Symbol	PRKM7
Symbol Alias	BMK1, ERK5
Approved Name	mitogen-activated protein kinase 7
Name Alias	"BMK1 kinase", "extracellular-signal-regulated kinase 5"
Location	17p11.2
Position	chr17:19281034-19286857, 1
External Links	HGNC: 6880 Entrez Gene: 5598 Ensembl: ENSG00000166484 UCSC: uc002gvp.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 38)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 38)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007165	signal transduction	biological process	TAS[7646528]	189
GO:0034115	negative regulation of heterotypic cell-cell adhesion	biological process	IGI	5
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	10
GO:0005524	ATP binding	molecular function	IEA	265
GO:0050728	negative regulation of inflammatory response	biological process	TAS	12
GO:0048011	nerve growth factor receptor signaling pathway	biological process	TAS	51
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IGI	141
GO:0030154	cell differentiation	biological process	IEA	61
GO:0006915	apoptotic process	biological process	IEA	127
GO:0008063	Toll signaling pathway	biological process	TAS	11
GO:0060761	negative regulation of response to cytokine stimulus	biological process	IGI	4
GO:0051247	positive regulation of protein metabolic process	biological process	IGI	3
GO:0051403	stress-activated MAPK cascade	biological process	TAS	10
GO:0034130	toll-like receptor 1 signaling pathway	biological process	TAS	10
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS	10
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	10
GO:0045087	innate immune response	biological process	TAS	57
GO:0005829	cytosol	cellular component	IDA; TAS	485
GO:0004707	MAP kinase activity	molecular function	IEA	3
GO:0071560	cellular response to transforming growth factor beta stimulus	biological process	IDA[18588859]	9
GO:0043066	negative regulation of apoptotic process	biological process	IC; IGI	85
GO:0018105	peptidyl-serine phosphorylation	biological process	IEA	13
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	11
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	biological process	IMP	1
GO:0045765	regulation of angiogenesis	biological process	IEA	3
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	10
GO:0051019	mitogen-activated protein kinase binding	molecular function	IPI	4
GO:0071363	cellular response to growth factor stimulus	biological process	IGI	8
GO:0060548	negative regulation of cell death	biological process	IMP	5
GO:0070301	cellular response to hydrogen peroxide	biological process	IMP	10
GO:0051534	negative regulation of NFAT protein import into nucleus	biological process	IEA	2
GO:0007049	cell cycle	biological process	IEA	36
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS	9
GO:0005515	protein binding	molecular function	IPI	1015
GO:0005634	nucleus	cellular component	IDA	877
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS	11
GO:0071499	cellular response to laminar fluid shear stress	biological process	IMP; TAS	2
GO:0005654	nucleoplasm	cellular component	TAS	210

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa04010	MAPK signaling pathway	68
hsa04540	Gap junction	30
hsa04912	GnRH signaling pathway	30

Genes shared at least 5 GO terms with MAPK7 (count: 67)

Gene Symbol	Pathway Count	Pathway List
MAPK1	22	signal transduction; toll-like receptor 2 signaling pathway; ATP binding; nerve growth factor receptor signaling pathway; apoptotic process; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; MAP kinase activity; peptidyl-serine phosphorylation; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cell cycle; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; toll-like receptor 3 signaling pathway; nucleoplasm;
MAPK3	21	toll-like receptor 2 signaling pathway; ATP binding; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; apoptotic process; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; MAP kinase activity; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cell cycle; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; toll-like receptor 3 signaling pathway; nucleoplasm;
UBC	17	toll-like receptor 2 signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; apoptotic process; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; toll-like receptor 3 signaling pathway; nucleoplasm;
RELA	17	toll-like receptor 2 signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; Toll signaling pathway; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; negative regulation of apoptotic process; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; toll-like receptor 3 signaling pathway; nucleoplasm;
UBB	17	toll-like receptor 2 signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; apoptotic process; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; toll-like receptor 3 signaling pathway; nucleoplasm;
MAP2K3	16	signal transduction; toll-like receptor 2 signaling pathway; ATP binding; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; toll-like receptor 3 signaling pathway; nucleoplasm;
MAPK9	16	toll-like receptor 2 signaling pathway; ATP binding; Toll signaling pathway; stress-activated MAPK cascade; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; cytosol; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; cellular response to growth factor stimulus; MyD88-independent toll-like receptor signaling pathway; protein binding; toll-like receptor 3 signaling pathway; nucleoplasm;
MAP2K5	13	signal transduction; negative regulation of heterotypic cell-cell adhesion; ATP binding; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; negative regulation of response to cytokine stimulus; positive regulation of protein metabolic process; cytosol; negative regulation of apoptotic process; cellular response to growth factor stimulus; protein binding; nucleus; cellular response to laminar fluid shear stress;
TLR4	11	toll-like receptor 2 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; Toll signaling pathway; toll-like receptor 1 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; protein binding; toll-like receptor 3 signaling pathway;
IRF7	11	positive regulation of transcription from RNA polymerase II promoter; Toll signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; cytosol; toll-like receptor 4 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; toll-like receptor 3 signaling pathway; nucleoplasm;
PRKD1	10	signal transduction; ATP binding; positive regulation of transcription from RNA polymerase II promoter; apoptotic process; innate immune response; cytosol; peptidyl-serine phosphorylation; negative regulation of cell death; protein binding; nucleus;
GSK3B	9	ATP binding; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cytosol; negative regulation of apoptotic process; peptidyl-serine phosphorylation; negative regulation of NFAT protein import into nucleus; protein binding; nucleus;
TIRAP	8	toll-like receptor 2 signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor signaling pathway; innate immune response; toll-like receptor 4 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; protein binding;
TGFBR1	7	signal transduction; ATP binding; apoptotic process; cellular response to transforming growth factor beta stimulus; negative regulation of apoptotic process; peptidyl-serine phosphorylation; protein binding;
PRKAA1	7	signal transduction; ATP binding; cytosol; negative regulation of apoptotic process; cellular response to hydrogen peroxide; protein binding; nucleus;
PLK1	7	ATP binding; cytosol; negative regulation of apoptotic process; peptidyl-serine phosphorylation; protein binding; nucleus; nucleoplasm;
SQSTM1	7	nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cell differentiation; apoptotic process; cytosol; protein binding; nucleoplasm;
NEK6	6	signal transduction; ATP binding; apoptotic process; peptidyl-serine phosphorylation; protein binding; nucleus;
NET1	6	signal transduction; nerve growth factor receptor signaling pathway; apoptotic process; cytosol; cellular response to hydrogen peroxide; nucleus;
ATM	6	signal transduction; ATP binding; negative regulation of apoptotic process; peptidyl-serine phosphorylation; protein binding; nucleoplasm;
ADRBK1	6	signal transduction; ATP binding; nerve growth factor receptor signaling pathway; cytosol; peptidyl-serine phosphorylation; protein binding;
KLF4	6	negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; positive regulation of transcription from RNA polymerase II promoter; negative regulation of response to cytokine stimulus; positive regulation of protein metabolic process; cellular response to growth factor stimulus;
PSMC3	6	ATP binding; apoptotic process; cytosol; protein binding; nucleus; nucleoplasm;
TNFAIP3	6	negative regulation of inflammatory response; innate immune response; cytosol; negative regulation of apoptotic process; protein binding; nucleus;
AATF	6	nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; apoptotic process; negative regulation of apoptotic process; protein binding; nucleus;
GATA6	6	positive regulation of transcription from RNA polymerase II promoter; apoptotic process; negative regulation of apoptotic process; protein binding; nucleus; nucleoplasm;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; cytosol; negative regulation of apoptotic process; protein binding; nucleus; nucleoplasm;
SMARCB1	6	positive regulation of transcription from RNA polymerase II promoter; cell differentiation; cell cycle; protein binding; nucleus; nucleoplasm;
WWOX	6	positive regulation of transcription from RNA polymerase II promoter; apoptotic process; cytosol; cellular response to transforming growth factor beta stimulus; protein binding; nucleus;
BNIP3	6	apoptotic process; negative regulation of apoptotic process; cellular response to hydrogen peroxide; protein binding; nucleus; nucleoplasm;
PAK7	5	signal transduction; ATP binding; apoptotic process; negative regulation of apoptotic process; nucleus;
CSNK1E	5	signal transduction; ATP binding; cytosol; protein binding; nucleus;
NR4A2	5	signal transduction; positive regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; nucleoplasm;
PYCARD	5	signal transduction; innate immune response; cytosol; protein binding; nucleus;
FGF4	5	signal transduction; positive regulation of transcription from RNA polymerase II promoter; cytosol; negative regulation of apoptotic process; nucleus;
TLE1	5	signal transduction; cytosol; protein binding; nucleus; nucleoplasm;
TXN	5	signal transduction; innate immune response; cytosol; protein binding; nucleoplasm;
CREBBP	5	signal transduction; innate immune response; protein binding; nucleus; nucleoplasm;
RIPK3	5	signal transduction; ATP binding; innate immune response; cytosol; protein binding;
SMC3	5	signal transduction; ATP binding; protein binding; nucleus; nucleoplasm;
CASP1	5	signal transduction; apoptotic process; innate immune response; cytosol; protein binding;
ERBB2	5	signal transduction; ATP binding; regulation of angiogenesis; protein binding; nucleus;
APOA1	5	negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of response to cytokine stimulus; protein binding; nucleus;
TRIO	5	ATP binding; nerve growth factor receptor signaling pathway; apoptotic process; cytosol; protein binding;
XRCC5	5	ATP binding; negative regulation of apoptotic process; protein binding; nucleus; nucleoplasm;
PIK3CG	5	ATP binding; innate immune response; cytosol; negative regulation of apoptotic process; protein binding;
PIK3C3	5	ATP binding; innate immune response; cytosol; cell cycle; protein binding;
DNAJA3	5	ATP binding; cytosol; negative regulation of apoptotic process; protein binding; nucleus;
SMG1	5	ATP binding; cytosol; peptidyl-serine phosphorylation; protein binding; nucleus;
CHEK1	5	ATP binding; cytosol; protein binding; nucleus; nucleoplasm;
PDPK1	5	ATP binding; nerve growth factor receptor signaling pathway; cytosol; protein binding; nucleoplasm;
KIF23	5	ATP binding; cytosol; protein binding; nucleus; nucleoplasm;
ARHGEF2	5	nerve growth factor receptor signaling pathway; apoptotic process; cytosol; negative regulation of apoptotic process; protein binding;
PIK3R1	5	nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; cytosol; negative regulation of apoptotic process; protein binding;
NR5A1	5	positive regulation of transcription from RNA polymerase II promoter; cell differentiation; protein binding; nucleus; nucleoplasm;
MEN1	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; protein binding; nucleus; nucleoplasm;
FADD	5	positive regulation of transcription from RNA polymerase II promoter; apoptotic process; innate immune response; cytosol; protein binding;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; protein binding; nucleus; nucleoplasm;
MED1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of apoptotic process; protein binding; nucleus; nucleoplasm;
RBM4	5	cell differentiation; stress-activated MAPK cascade; protein binding; nucleus; nucleoplasm;
EGLN3	5	apoptotic process; cytosol; protein binding; nucleus; nucleoplasm;
APC	5	apoptotic process; cytosol; negative regulation of apoptotic process; protein binding; nucleus;
BIRC2	5	apoptotic process; cytosol; negative regulation of apoptotic process; protein binding; nucleus;
TAX1BP1	5	apoptotic process; innate immune response; cytosol; negative regulation of apoptotic process; protein binding;
DAB2	5	apoptotic process; cellular response to transforming growth factor beta stimulus; negative regulation of apoptotic process; protein binding; nucleus;
CRYAB	5	stress-activated MAPK cascade; cytosol; negative regulation of apoptotic process; protein binding; nucleus;
MALT1	5	innate immune response; cytosol; negative regulation of apoptotic process; protein binding; nucleus;

Genes shared at least 2 KEGG pathways with MAPK7 (count: 26)

Gene Symbol	Pathway Count	Pathway List
MAPK1	3	MAPK signaling pathway; Gap junction; GnRH signaling pathway;
MAPK3	3	MAPK signaling pathway; Gap junction; GnRH signaling pathway;
PLA2G2D	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1D	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G4B	2	MAPK signaling pathway; GnRH signaling pathway;
MAP2K3	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G3	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1C	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G6	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G5	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G1B	2	MAPK signaling pathway; GnRH signaling pathway;
CACNA1F	2	MAPK signaling pathway; GnRH signaling pathway;
MAP2K5	2	MAPK signaling pathway; Gap junction;
CACNA1S	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G2A	2	MAPK signaling pathway; GnRH signaling pathway;
MAPK9	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G10	2	MAPK signaling pathway; GnRH signaling pathway;
PLA2G2E	2	MAPK signaling pathway; GnRH signaling pathway;
ADCY4	2	Gap junction; GnRH signaling pathway;
ITPR1	2	Gap junction; GnRH signaling pathway;
ADCY3	2	Gap junction; GnRH signaling pathway;
ITPR2	2	Gap junction; GnRH signaling pathway;
ADCY2	2	Gap junction; GnRH signaling pathway;
ADCY9	2	Gap junction; GnRH signaling pathway;
PLCB2	2	Gap junction; GnRH signaling pathway;
PLCB3	2	Gap junction; GnRH signaling pathway;

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Region: chr17:19281034..19286857 View in gBrowse