ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MAPK7
Previous Symbol	PRKM7
Symbol Alias	BMK1, ERK5
Approved Name	mitogen-activated protein kinase 7
Name Alias	BMK1 kinase, "extracellular-signal-regulated kinase 5"
Location	17p11.2
Position	chr17:19281034-19286857, +
External Links	HGNC: 6880 Entrez Gene: 5598 Ensembl: ENSG00000166484 UCSC: uc002gvp.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 38)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 38)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071499	cellular response to laminar fluid shear stress	Biological Process		1
GO:0071560	cellular response to transforming growth factor beta stimulus	Biological Process	IDA[18588859]	9
GO:0070301	cellular response to hydrogen peroxide	Biological Process		10
GO:0071363	cellular response to growth factor stimulus	Biological Process		6
GO:0007049	cell cycle	Biological Process		31
GO:0007165	signal transduction	Biological Process	TAS[7646528]	171
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0018105	peptidyl-serine phosphorylation	Biological Process		12
GO:0030154	cell differentiation	Biological Process		51
GO:0034115	negative regulation of heterotypic cell-cell adhesion	Biological Process		4
GO:0034130	toll-like receptor 1 signaling pathway	Biological Process		10
GO:0034134	toll-like receptor 2 signaling pathway	Biological Process		10
GO:0002756	MyD88-independent toll-like receptor signaling pathway	Biological Process		9
GO:0004707	MAP kinase activity	Molecular Function		3
GO:0005515	protein binding	Molecular Function		910
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component		770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005829	cytosol	Cellular Component		447
GO:0002224	toll-like receptor signaling pathway	Biological Process		10
GO:0006915	apoptotic process	Biological Process		111
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0050728	negative regulation of inflammatory response	Biological Process		11
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0051247	positive regulation of protein metabolic process	Biological Process		2
GO:0051019	mitogen-activated protein kinase binding	Molecular Function		4
GO:0051534	negative regulation of NFAT protein import into nucleus	Biological Process		2
GO:0051403	stress-activated MAPK cascade	Biological Process		10
GO:0060761	negative regulation of response to cytokine stimulus	Biological Process		3
GO:0060548	negative regulation of cell death	Biological Process		5
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process		11
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	Biological Process		1
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0045087	innate immune response	Biological Process		54
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131
GO:0045765	regulation of angiogenesis	Biological Process		3

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04912	GnRH signaling pathway	28	Gonadotropin-releasing hormone (GnRH) secretion from the hyp...... Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes. More...
hsa04540	Gap junction	27	Gap junctions contain intercellular channels that allow dire...... Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation. More...
hsa04722	Neurotrophin signaling pathway	24	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with MAPK7 (count: 63)

Gene Symbol	Pathway Count	Pathway List
MAPK1	22	cell cycle; signal transduction; Toll signaling pathway; peptidyl-serine phosphorylation; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAP kinase activity; protein binding; ATP binding; nucleus; nucleoplasm; cytosol; toll-like receptor signaling pathway; apoptotic process; MyD88-dependent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response;
MAPK3	21	cell cycle; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; MAP kinase activity; protein binding; ATP binding; nucleus; nucleoplasm; cytosol; toll-like receptor signaling pathway; apoptotic process; MyD88-dependent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
RELA	17	Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
UBB	17	Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; apoptotic process; MyD88-dependent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
UBC	17	Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; apoptotic process; MyD88-dependent toll-like receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
MAPK9	16	cellular response to growth factor stimulus; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; ATP binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response;
MAP2K3	16	signal transduction; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; ATP binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response;
IRF7	11	Toll signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleus; nucleoplasm; cytosol; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
TLR4	11	Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; protein binding; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
PRKD1	10	signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus; cytosol; apoptotic process; negative regulation of cell death; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
GSK3B	9	peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus; cytosol; nerve growth factor receptor signaling pathway; negative regulation of NFAT protein import into nucleus; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
TIRAP	8	Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; protein binding; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response;
TGFBR1	7	cellular response to transforming growth factor beta stimulus; signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding; apoptotic process; negative regulation of apoptotic process;
PRKAA1	7	cellular response to hydrogen peroxide; signal transduction; protein binding; ATP binding; nucleus; cytosol; negative regulation of apoptotic process;
PLK1	7	peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus; nucleoplasm; cytosol; negative regulation of apoptotic process;
SQSTM1	7	cell differentiation; protein binding; nucleoplasm; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
WWOX	6	cellular response to transforming growth factor beta stimulus; protein binding; nucleus; cytosol; apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
BNIP3	6	cellular response to hydrogen peroxide; protein binding; nucleus; nucleoplasm; apoptotic process; negative regulation of apoptotic process;
NET1	6	cellular response to hydrogen peroxide; signal transduction; nucleus; cytosol; apoptotic process; nerve growth factor receptor signaling pathway;
KLF4	6	cellular response to growth factor stimulus; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; positive regulation of protein metabolic process; negative regulation of response to cytokine stimulus; positive regulation of transcription from RNA polymerase II promoter;
SMARCB1	6	cell cycle; cell differentiation; protein binding; nucleus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter;
ADRBK1	6	signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding; cytosol; nerve growth factor receptor signaling pathway;
ATM	6	signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding; nucleoplasm; negative regulation of apoptotic process;
NEK6	6	signal transduction; peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus; apoptotic process;
PRKCB	6	signal transduction; protein binding; ATP binding; nucleus; cytosol; apoptotic process;
AATF	6	protein binding; nucleus; apoptotic process; nerve growth factor receptor signaling pathway; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
GATA6	6	protein binding; nucleus; nucleoplasm; apoptotic process; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
PSMC3	6	protein binding; ATP binding; nucleus; nucleoplasm; cytosol; apoptotic process;
TNFAIP3	6	protein binding; nucleus; cytosol; negative regulation of inflammatory response; innate immune response; negative regulation of apoptotic process;
YAP1	6	protein binding; nucleus; nucleoplasm; cytosol; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
DAB2	5	cellular response to transforming growth factor beta stimulus; protein binding; nucleus; apoptotic process; negative regulation of apoptotic process;
PIK3C3	5	cell cycle; protein binding; ATP binding; cytosol; innate immune response;
CASP1	5	signal transduction; protein binding; cytosol; apoptotic process; innate immune response;
CSNK1E	5	signal transduction; protein binding; ATP binding; nucleus; cytosol;
ERBB2	5	signal transduction; protein binding; ATP binding; nucleus; regulation of angiogenesis;
FGF4	5	signal transduction; nucleus; cytosol; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
NR4A2	5	signal transduction; protein binding; nucleus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter;
PAK7	5	signal transduction; ATP binding; nucleus; apoptotic process; negative regulation of apoptotic process;
PYCARD	5	signal transduction; protein binding; nucleus; cytosol; innate immune response;
RIPK3	5	signal transduction; protein binding; ATP binding; cytosol; innate immune response;
SMC3	5	signal transduction; protein binding; ATP binding; nucleus; nucleoplasm;
TXN	5	signal transduction; protein binding; nucleoplasm; cytosol; innate immune response;
SMG1	5	peptidyl-serine phosphorylation; protein binding; ATP binding; nucleus; cytosol;
NR5A1	5	cell differentiation; protein binding; nucleus; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter;
RBM4	5	cell differentiation; protein binding; nucleus; nucleoplasm; stress-activated MAPK cascade;
APOA1	5	negative regulation of heterotypic cell-cell adhesion; protein binding; nucleus; negative regulation of inflammatory response; negative regulation of response to cytokine stimulus;
APC	5	protein binding; nucleus; cytosol; apoptotic process; negative regulation of apoptotic process;
ARHGEF2	5	protein binding; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; negative regulation of apoptotic process;
BIRC2	5	protein binding; nucleus; cytosol; apoptotic process; negative regulation of apoptotic process;
CHEK1	5	protein binding; ATP binding; nucleus; nucleoplasm; cytosol;
CRYAB	5	protein binding; nucleus; cytosol; stress-activated MAPK cascade; negative regulation of apoptotic process;
EGLN3	5	protein binding; nucleus; nucleoplasm; cytosol; apoptotic process;
FADD	5	protein binding; cytosol; apoptotic process; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
KDM1A	5	protein binding; nucleus; nucleoplasm; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
KIF23	5	protein binding; ATP binding; nucleus; nucleoplasm; cytosol;
MALT1	5	protein binding; nucleus; cytosol; innate immune response; negative regulation of apoptotic process;
MED1	5	protein binding; nucleus; nucleoplasm; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
MEN1	5	protein binding; nucleus; nucleoplasm; cytosol; positive regulation of transcription from RNA polymerase II promoter;
PIK3CG	5	protein binding; ATP binding; cytosol; innate immune response; negative regulation of apoptotic process;
PIK3R1	5	protein binding; cytosol; nerve growth factor receptor signaling pathway; negative regulation of apoptotic process; positive regulation of transcription from RNA polymerase II promoter;
TAX1BP1	5	protein binding; cytosol; apoptotic process; innate immune response; negative regulation of apoptotic process;
TRIO	5	protein binding; ATP binding; cytosol; apoptotic process; nerve growth factor receptor signaling pathway;
XRCC5	5	protein binding; ATP binding; nucleus; nucleoplasm; negative regulation of apoptotic process;

Genes shared at least 2 KEGG pathways with MAPK7 (count: 32)

Gene Symbol	Pathway Count	Pathway List
MAPK1	4	GnRH signaling pathway; Gap junction; Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK3	4	GnRH signaling pathway; Gap junction; Neurotrophin signaling pathway; MAPK signaling pathway;
MAPK9	3	GnRH signaling pathway; Neurotrophin signaling pathway; MAPK signaling pathway;
PRKCB	3	GnRH signaling pathway; Gap junction; MAPK signaling pathway;
ADCY4	2	GnRH signaling pathway; Gap junction;
CACNA1C	2	GnRH signaling pathway; MAPK signaling pathway;
CACNA1D	2	GnRH signaling pathway; MAPK signaling pathway;
CACNA1F	2	GnRH signaling pathway; MAPK signaling pathway;
CACNA1S	2	GnRH signaling pathway; MAPK signaling pathway;
CAMK2D	2	GnRH signaling pathway; Neurotrophin signaling pathway;
ITPR1	2	GnRH signaling pathway; Gap junction;
ITPR2	2	GnRH signaling pathway; Gap junction;
MAP2K3	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G10	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G1B	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G2A	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G2D	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G2E	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G3	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G4B	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G5	2	GnRH signaling pathway; MAPK signaling pathway;
PLA2G6	2	GnRH signaling pathway; MAPK signaling pathway;
PLCB2	2	GnRH signaling pathway; Gap junction;
PLCB3	2	GnRH signaling pathway; Gap junction;
BDNF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
CRKL	2	Neurotrophin signaling pathway; MAPK signaling pathway;
MAP3K5	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NGF	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NTF3	2	Neurotrophin signaling pathway; MAPK signaling pathway;
NTRK2	2	Neurotrophin signaling pathway; MAPK signaling pathway;
RELA	2	Neurotrophin signaling pathway; MAPK signaling pathway;
RPS6KA4	2	Neurotrophin signaling pathway; MAPK signaling pathway;

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Region: chr17:19281034..19286857 View in gBrowse