ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NET1
Symbol Alias	ARHGEF8, NET1A
Approved Name	neuroepithelial cell transforming 1
Location	10p15
Position	chr10:5454514-5500426, +
External Links	HGNC: 14592 Entrez Gene: 10276 Ensembl: ENSG00000173848 UCSC: uc001iia.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Literature-origin

Gene related studies (count: 0)

Gene related SNPs (count: 27)

Literature-origin SNPs (count: 27)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs1814269	Chr16:55717028(Fwd)	feature_truncation; intron_variant	2(0/2/0)
rs998424	Chr16:55731946(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	7(2/5/0)
rs1861647	Chr16:55728406(Fwd)	downstream_gene_variant; intron_variant	1(0/1/0)
rs12596924	Chr16:55744647(Fwd)	downstream_gene_variant	1(0/1/0)
rs42460	Chr16:55737656(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)
rs16955708	Chr16:55741456(Fwd)	downstream_gene_variant	1(0/1/0)
rs11568324	Chr16:55726058(Fwd)	intron_variant	5(4/1/0)
rs258099	Chr16:55747177(Fwd)		1(0/1/0)
rs3785157	Chr16:55729836(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	5(3/2/0)
rs3785151	Chr16:55712519(Fwd)	intron_variant	1(0/1/0)
rs3785152	Chr16:55716550(Fwd)	intron_variant	2(0/2/0)
rs3785143	Chr16:55695106(Fwd)	intron_variant	6(5/1/0)
rs15534	Chr16:55736527(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant	2(0/2/0)
rs36020	Chr16:55713088(Fwd)	intron_variant	1(0/1/0)
rs36009	Chr16:55732620(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	3(1/2/0)
rs1532701	Chr16:55698027(Fwd)	intron_variant	1(0/1/0)
rs36021	Chr16:55711950(Fwd)	intron_variant	3(1/2/0)
rs36030	Chr16:55693290(Fwd)	intron_variant	1(0/1/0)
rs36024	Chr16:55706391(Fwd)	downstream_gene_variant; intron_variant	3(0/3/0)
rs2242447	Chr16:55735912(Fwd)	intron_variant	6(1/5/0)
rs40147	Chr16:55716840(Fwd)	intron_variant	1(0/1/0)
rs192303	Chr16:55700224(Fwd)	intron_variant	2(0/2/0)
rs5568	Chr16:55730124(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	2(0/2/0)
rs5569	Chr16:55731835(Fwd)	downstream_gene_variant; synonymous_variant; upstream_gene_variant	6(1/4/1)
rs1948773	Chr16:55746946(Fwd)		1(0/1/0)
rs17306977	Chr16:55693373(Fwd)	intron_variant	1(0/1/0)
rs10521329	Chr16:55720458(Fwd)	intron_variant	2(0/2/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001558	regulation of cell growth	Biological Process	NAS[8649828]	11
GO:0005543	phospholipid binding	Molecular Function		61
GO:0005634	nucleus	Cellular Component		770
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS[8649828]	17
GO:0005089	Rho guanyl-nucleotide exchange factor activity	Molecular Function		11
GO:0007165	signal transduction	Biological Process	TAS[8649828]	171
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0005829	cytosol	Cellular Component		447
GO:0006915	apoptotic process	Biological Process		111
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0032321	positive regulation of Rho GTPase activity	Biological Process		6
GO:0043065	positive regulation of apoptotic process	Biological Process		34
GO:0071479	cellular response to ionizing radiation	Biological Process		4
GO:0070301	cellular response to hydrogen peroxide	Biological Process		10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NET1 (count: 14)

Gene Symbol	Pathway Count	Pathway List
ARHGEF4	8	phospholipid binding; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
FGD3	8	phospholipid binding; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
TIAM2	8	phospholipid binding; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
TRIO	8	phospholipid binding; guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
ARHGEF12	7	phospholipid binding; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
ARHGEF2	7	phospholipid binding; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
ARHGEF17	7	guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
MAPK1	6	nucleus; signal transduction; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway;
MAPK7	6	nucleus; signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; cellular response to hydrogen peroxide;
MCF2L	6	Rho guanyl-nucleotide exchange factor activity; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; regulation of small GTPase mediated signal transduction;
RASGRP2	5	regulation of cell growth; guanyl-nucleotide exchange factor activity; signal transduction; cytosol; regulation of small GTPase mediated signal transduction;
BAD	5	phospholipid binding; cytosol; apoptotic process; nerve growth factor receptor signaling pathway; positive regulation of apoptotic process;
PRKD1	5	phospholipid binding; nucleus; signal transduction; cytosol; apoptotic process;
MAPK3	5	nucleus; small GTPase mediated signal transduction; cytosol; apoptotic process; nerve growth factor receptor signaling pathway;

Genes shared at least 2 KEGG pathways with NET1 (count: 0)

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Region: chr10:5454514..5500426 View in gBrowse