ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RASGRP2
Symbol Alias	CALDAG-GEFI
Approved Name	RAS guanyl releasing protein 2 (calcium and DAG-regulated)
Location	11q13
Position	chr11:64494383-64512928, -
External Links	HGNC: 9879 Entrez Gene: 10235 UCSC: uc009ypv.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001558	regulation of cell growth	Biological Process	NAS[10918068]	11
GO:0007596	blood coagulation	Biological Process		83
GO:0008289	lipid binding	Molecular Function	TAS[9789079]	23
GO:0007165	signal transduction	Biological Process	TAS[9789079]	171
GO:0007265	Ras protein signal transduction	Biological Process	NAS[10918068]	15
GO:0005829	cytosol	Cellular Component	IDA[10918068]	447
GO:0005886	plasma membrane	Cellular Component	IDA[10918068]	772
GO:0005085	guanyl-nucleotide exchange factor activity	Molecular Function	TAS[9789079]	17
GO:0005509	calcium ion binding	Molecular Function	NAS[10918068]; TAS[9789079]	124
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0043005	neuron projection	Cellular Component		35
GO:0045202	synapse	Cellular Component		31
GO:0030168	platelet activation	Biological Process		38
GO:0032587	ruffle membrane	Cellular Component		12
GO:0019992	diacylglycerol binding	Molecular Function	NAS[10918068]	2
GO:0030054	cell junction	Cellular Component		77

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with RASGRP2 (count: 8)

Gene Symbol	Pathway Count	Pathway List
PLCE1	6	regulation of cell growth; Ras protein signal transduction; cytosol; plasma membrane; guanyl-nucleotide exchange factor activity; calcium ion binding;
ADRA2A	6	blood coagulation; signal transduction; Ras protein signal transduction; plasma membrane; synapse; platelet activation;
BCAR1	5	regulation of cell growth; blood coagulation; cytosol; plasma membrane; platelet activation;
NET1	5	regulation of cell growth; signal transduction; cytosol; guanyl-nucleotide exchange factor activity; regulation of small GTPase mediated signal transduction;
MAPK1	5	blood coagulation; signal transduction; Ras protein signal transduction; cytosol; platelet activation;
MGLL	5	blood coagulation; lipid binding; plasma membrane; synapse; platelet activation;
PRKCB	5	blood coagulation; signal transduction; cytosol; plasma membrane; platelet activation;
DTNA	5	signal transduction; plasma membrane; calcium ion binding; synapse; cell junction;

Genes shared at least 2 KEGG pathways with RASGRP2 (count: 8)

Gene Symbol	Pathway Count	Pathway List
ARRB1	2	Chemokine signaling pathway; MAPK signaling pathway;
ARRB2	2	Chemokine signaling pathway; MAPK signaling pathway;
CRKL	2	Chemokine signaling pathway; MAPK signaling pathway;
MAPK1	2	Chemokine signaling pathway; MAPK signaling pathway;
MAPK3	2	Chemokine signaling pathway; MAPK signaling pathway;
PAK1	2	Chemokine signaling pathway; MAPK signaling pathway;
PRKCB	2	Chemokine signaling pathway; MAPK signaling pathway;
RELA	2	Chemokine signaling pathway; MAPK signaling pathway;

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Region: chr11:64494383..64512928 View in gBrowse