ADHDgene Database

SNP Report

Basic Info

Name	rs36009 dbSNP Ensembl
Location	Chr16:55732620(Fwd)
Variant Alleles	C/T
Ancestral Allele	C
Functional Annotation	downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000568529) intron_variant(ENST00000567238; ENST00000414754; ENST00000219833; ENST00000568943; ENST00000379906; ENST00000561820; ENST00000566163) upstream_gene_variant(ENST00000574918)
No. of Studies	3 (significant: 1; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Guan L, 2009			single SNP association analyses: Nominal P-value=0.018, Empi...... single SNP association analyses: Nominal P-value=0.018, Empirical P-value=0.267 for ADHD-C More...	non-significant for ADHD, but achieve nominal significance f...... non-significant for ADHD, but achieve nominal significance for ADHD-C More...	Significant
Sengupta, S. M., 2012	G/A		P-value=0.44, Z statistic (allele 1)=0.77 P-value=0.44, Z statistic (allele 1)=0.77	No significant association was found in this study. No significant association was found in this study.	Non-significant
Hawi, Z., 2012	G:A	G	P-value=0.2513, X²=1.32, OR=1.3, 95% CI=0.83-2.04 P-value=0.2513, X²=1.32, OR=1.3, 95% CI=0.83-2.04	The marker did not show significant association with ADHD. The marker did not show significant association with ADHD.	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	16q12.2	16(10/5/1)
NET1	neuroepithelial cell transforming 1	10p15	0

SNPs in LD with rs36009 (count: 8) View in gBrowse (chr16:55725975..55790108 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs42460	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1(0/1/0)	0.879[CEU]; 0.837[CHD]; 0.904[GIH]; 0.85[JPT]; 1.0[TSI]
rs5564	intron_variant	1(0/1/0)	1.0[MEX]
rs1948773		1(0/1/0)	0.825[YRI]

rs_ID	Functional Annotation	r²[population]
rs1807210	intron_variant; nc_transcript_variant	0.865[CEU]
rs12149310	downstream_gene_variant; intron_variant	1.0[MEX]
rs12600068	upstream_gene_variant	0.847[CEU]
rs36007	intron_variant	0.92[CHB]; 1.0[JPT]; 1.0[YRI]
rs2894949	downstream_gene_variant	0.865[CEU]