Reference |
Statistical Values/Author Comments |
Result of Statistical Analysis |
Joung Y, 2010 |
significant differences in the allele and genotypes frequencies of SLC6A2 -3081(A/T) polymorphism between cases and controls |
Significant
|
Hahn MK, 2009 |
Four coding region SNPs were identified. Two were synonymous, two were nonsynonymous. Three have been observed in the NET gene previously, whereas one is a novel variant. The novel SNP is nonsynonymous, generating the protein variant T283M. |
Trend
|
Biederman J, 2008 |
rs3785143 showed nominally significant association in the full sample and the T allele displayed a stronger effect in females than in males |
Significant
|
Gizer IR, 2009 |
The present study does not support a relation between ADHD and this gene. |
Non-significant
|
Cho SC, 2008 |
no polymorphism and haplotype showed significant associations with ADHD |
Non-significant
|
Xu X, 2008(b) |
the overall evidence of association with ADHD was significant for 2 SNPs across all four datasets |
Significant
|
Kim CH, 2006 |
a significant association was observed between the -3081(A/T) polymorphism and ADHD |
Significant
|
Guan L, 2009 |
1 SNP in this gene achieved significance for ADHD-C in single SNP association analysis. |
Significant
|
Sengupta, S. M., 2012 |
The 5' region of the gene (encompassing haplotype block 1 and including a functional promoter SNP, rs28386840) showed an association with ADHD in girls (irrespective of subtype). A different region of the gene (distributed around haplo-type block 2) was associated with distinct behavioural phenotypes in boys. These findings are correlated with previously reported functional studies of gene variants in SLC6A2. |
Significant
|
Hawi, Z., 2012 |
Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. In contrast, haplotype analyses demonstrated a significant association between ADHD and a SLC6A2 haplotype comprising the markers rs36009, rs1800887, rs8049681, rs2242447 and rs9930182 (chi(2) = 9.39, p-corrected = 0.019, OR = 1.51). These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD. |
Significant
|
Ilott NE, 2010 |
2 SNPs showed modest, nominally significant association in the AT and AW tests at age 2, and 1 SNP showed modest, nominally significant association in the AW tests at ages 2 and 3 |
Significant
|
Renner, T. J., 2011 |
We conclude that A-3081T is not a major risk variant in our ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype. |
Non-significant
|
McEvoy B, 2002 |
On the basis of results in this study it appears that the NET protein does not play a role in predisposing to ADHD at least in this Irish population. |
Non-significant
|
Barr CL, 2002 |
TRANSMIT haplotype analysis: smallest P=0.277. Rresults in this study do not support the NET1 gene as a major genetic susceptibility factor in ADHD. |
Non-significant
|
Xu X, 2005(a) |
showed trends for association with rs3785157 (P=0.034) and rs998424 (P=0.066); haplotype analysis did not provide additional evidence of association |
Significant
|
Bobb AJ, 2005 |
revealed significant association of two SNPs with ADHD |
Significant
|