ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

Gene Report

Basic Info
Approved Symbol SLC6A2
Previous Symbol NET1, NAT1, SLC6A5
Approved Name solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2
Location 16q12.2
Position chr16:55671012-55740104, +
External Links HGNC: 11048
Entrez Gene: 6530
Ensembl: ENSG00000103546
UCSC: uc002eih.2
No. of Studies 16 (significant: 10; non-significant: 5; trend: 1)
Source Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 16)
Reference Statistical Values/Author Comments Result of Statistical Analysis
Joung Y, 2010 significant differences in the allele and genotypes frequencies of SLC6A2 -3081(A/T) polymorphism between cases and controls Significant
Hahn MK, 2009 Four coding region SNPs were identified. Two were synonymous, two were nonsynonymous. Three have been observed in the NET gene previously, whereas one is a novel variant. The novel SNP is nonsynonymous, generating the protein variant T283M. Trend
Biederman J, 2008 rs3785143 showed nominally significant association in the full sample and the T allele displayed a stronger effect in females than in males Significant
Gizer IR, 2009 The present study does not support a relation between ADHD and this gene. Non-significant
Cho SC, 2008 no polymorphism and haplotype showed significant associations with ADHD Non-significant
Xu X, 2008(b) the overall evidence of association with ADHD was significant for 2 SNPs across all four datasets Significant
Kim CH, 2006 a significant association was observed between the -3081(A/T) polymorphism and ADHD Significant
Guan L, 2009 1 SNP in this gene achieved significance for ADHD-C in single SNP association analysis. Significant
Sengupta, S. M., 2012 The 5' region of the gene (encompassing haplotype block 1 and including a functional promoter SNP, rs28386840) showed an association with ADHD in girls (irrespective of subtype). A different region of the gene (distributed around haplo-type block 2) was associated with distinct behavioural phenotypes in boys. These findings are correlated with previously reported functional studies of gene variants in SLC6A2. Significant
Hawi, Z., 2012 Although suggestive evidence of association (nominal p <= 0.05) with the genes SLC6A2, ADRA1A, ADRA1B and ADRA2B was observed, none remained significant after permutation adjustments. In contrast, haplotype analyses demonstrated a significant association between ADHD and a SLC6A2 haplotype comprising the markers rs36009, rs1800887, rs8049681, rs2242447 and rs9930182 (chi(2) = 9.39, p-corrected = 0.019, OR = 1.51). These findings provide evidence of a contribution of the noradrenaline system to the genetic aetiology of ADHD. Significant
Ilott NE, 2010 2 SNPs showed modest, nominally significant association in the AT and AW tests at age 2, and 1 SNP showed modest, nominally significant association in the AW tests at ages 2 and 3 Significant
Renner, T. J., 2011 We conclude that A-3081T is not a major risk variant in our ADHD sample, though SLC6A2 remains an interesting candidate gene in ADHD, especially for the inattentive subtype. Non-significant
McEvoy B, 2002 On the basis of results in this study it appears that the NET protein does not play a role in predisposing to ADHD at least in this Irish population. Non-significant
Barr CL, 2002 TRANSMIT haplotype analysis: smallest P=0.277. Rresults in this study do not support the NET1 gene as a major genetic susceptibility factor in ADHD. Non-significant
Xu X, 2005(a) showed trends for association with rs3785157 (P=0.034) and rs998424 (P=0.066); haplotype analysis did not provide additional evidence of association Significant
Bobb AJ, 2005 revealed significant association of two SNPs with ADHD Significant

Gene related SNPs (count: 113)

Literature-origin SNPs (count: 47)

LD-proxies (count: 66)

Gene related CNVs (count: 0)

Gene related other variant (count: 6)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 10)

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with SLC6A2 (count: 13)

Genes shared at least 2 KEGG pathways with SLC6A2 (count: 0)

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Region: chr16:55671012..55740104 View in gBrowse
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