ADHDgene Database

SNP Report

Basic Info

Name	rs8047672 dbSNP Ensembl
Location	Chr16:55731735(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	downstream_gene_variant; intron_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000568529) intron_variant(ENST00000561820; ENST00000566163; ENST00000414754; ENST00000379906; ENST00000567238; ENST00000219833; ENST00000568943) upstream_gene_variant(ENST00000574918)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Sengupta, S. M., 2012	G/A		P-value=0.94, Z statistic (allele 1)=¨C0.08 P-value=0.94, Z statistic (allele 1)=¨C0.08	No significant association was found in this study. No significant association was found in this study.	Non-significant
Hawi, Z., 2012	G:A	G	P-value=0.0072, X²=7.21, OR=2.04, 95% CI=1.47-2....... P-value=0.0072, X²=7.21, OR=2.04, 95% CI=1.47-2.80 More...	Nominal associations between ADHD and the marker was observe...... Nominal associations between ADHD and the marker was observed. However, the association did not remain significant after adjusting the p values using 10,000 permutations. More...	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	16q12.2	16(10/5/1)

SNPs in LD with rs8047672 (count: 28) View in gBrowse (chr16:55717483..55926803 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs9930182	downstream_gene_variant	1(0/1/0)	1.0[JPT]
rs7188230	downstream_gene_variant	1(0/1/0)	1.0[JPT]
rs10521329	intron_variant	2(0/2/0)	1.0[CEU]; 1.0[JPT]
rs15534	3_prime_UTR_variant; downstream_gene_variant; intron_variant	2(0/2/0)	1.0[JPT]
rs1800887	intron_variant; upstream_gene_variant	2(0/2/0)	1.0[JPT]
rs8049681	intron_variant	1(0/1/0)	1.0[JPT]
rs16955708	downstream_gene_variant	1(0/1/0)	1.0[JPT]

rs_ID	Functional Annotation	r²[population]
rs880711	intron_variant	1.0[JPT]
rs2253971	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]
rs6499799	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CHB]
rs10521330	downstream_gene_variant	1.0[JPT]
rs12708954	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs879520	intron_variant	1.0[JPT]
rs12929956	downstream_gene_variant	1.0[JPT]
rs6499773	downstream_gene_variant; intron_variant	1.0[JPT]
rs2254462	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CHB]
rs7189204	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]
rs9746865	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CHB]
rs7194256	3_prime_UTR_variant; downstream_gene_variant; intron_variant	1.0[JPT]
rs7404321	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CHB]
rs8050050	intron_variant	1.0[JPT]
rs1861646	intron_variant	1.0[CEU]; 1.0[JPT]
rs6416763	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]
rs11866627	intron_variant	1.0[JPT]
rs13330300	intron_variant	1.0[JPT]
rs2253986	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]
rs11649052	intron_variant	1.0[JPT]
rs2253978	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]