Gene Report
Basic Info
Approved Symbol |
ABCC1
|
Previous Symbol |
MRP, MRP1 |
Symbol Alias |
GS-X |
Approved Name |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
Previous Name |
multidrug resistance associated protein 1 |
Location |
16p13.1 |
Position |
chr16:16043434-16236931, + |
External Links |
HGNC: 51
Entrez Gene: 4363
Ensembl: ENSG00000103222
UCSC: uc010bvi.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV; Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 9)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 14)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa02010 |
ABC transporters |
7 |
The ATP-binding cassette (ABC) transporters form one of the ......
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
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|
hsa04977 |
Vitamin digestion and absorption |
7 |
Vitamins are a diverse and chemically unrelated group of org......
Vitamins are a diverse and chemically unrelated group of organic substances that share a common feature of being essential for normal health and well-being. They catalyze numerous biochemical reactions. Because humans and other mammals cannot synthesize these compounds (except for some synthesis of niacin), they must obtain them from exogenous sources via intestinal absorption. Vitamins are classified based on their solubility in water or fat. Most of the water-soluble vitamins are transported across the small intestinal membrane by carrier-mediated mechanisms, but vitamin B12, cobalamin, is transported by a receptor-mediated mechanism. Intestinal absorption of fat-soluble vitamins requires all of the processes needed for fat absorption. After digestion, these vitamins and the products of pancreatic hydrolysis of triglycerides (TG) are emulsified by bile salts to form mixed micelles which are taken up by intestinal enterocytes and incorporated into chylomicrons (CM). CM are then secreted into the lymphatic system, and finally moves into the plasma.
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|
Genes shared at least 5 GO terms with ABCC1 (count: 16)
Genes shared at least 2 KEGG pathways with ABCC1 (count: 0)
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