ADHDgene Database

Gene Report

Basic Info

Approved Symbol	ABCB6
Symbol Alias	EST45597, umat, MTABC3
Approved Name	ATP-binding cassette, sub-family B (MDR/TAP), member 6
Name Alias	ATP-binding cassette half-transporter
Location	2q36
Position	chr2:220074490-220083712, -
External Links	HGNC: 47 Entrez Gene: 10058 Ensembl: ENSG00000115657 UCSC: uc002vkc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
2q35	chr2:215300000-221500000	1 (1/0/0)

Gene related GO terms (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0070574	cadmium ion transmembrane transport	Biological Process		2
GO:0055085	transmembrane transport	Biological Process		82
GO:0043588	skin development	Biological Process		7
GO:0043190	ATP-binding cassette (ABC) transporter complex	Cellular Component	NAS[11955620]	1
GO:0071585	detoxification of cadmium ion	Biological Process		1
GO:0015439	heme-transporting ATPase activity	Molecular Function	IMP[17006453]	1
GO:0015232	heme transporter activity	Molecular Function		3
GO:0007420	brain development	Biological Process		33
GO:0006879	cellular iron ion homeostasis	Biological Process	NAS[11977179]	12
GO:0031307	integral to mitochondrial outer membrane	Cellular Component	IDA[17661442]	3
GO:0020037	heme binding	Molecular Function	IDA[17006453]	23
GO:0015886	heme transport	Biological Process	IDA[17661442]; IMP[17006453]	3
GO:0015562	efflux transmembrane transporter activity	Molecular Function	IDA[17661442]	1
GO:0005740	mitochondrial envelope	Cellular Component	IDA[10837493]	3
GO:0005741	mitochondrial outer membrane	Cellular Component	IDA[17006453]	21
GO:0005774	vacuolar membrane	Cellular Component		3
GO:0005783	endoplasmic reticulum	Cellular Component		100
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005886	plasma membrane	Cellular Component	IDA[17661442]	772
GO:0006779	porphyrin-containing compound biosynthetic process	Biological Process	IDA[17006453]	1
GO:0006810	transport	Biological Process	IDA[10837493]	62
GO:0005524	ATP binding	Molecular Function	IDA[10837493]	228
GO:0005739	mitochondrion	Cellular Component	IDA[10837493,18279659]	183

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa02010	ABC transporters	7	The ATP-binding cassette (ABC) transporters form one of the ...... The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD). More...

Genes shared at least 5 GO terms with ABCB6 (count: 2)

Gene Symbol	Pathway Count	Pathway List
ABCG2	7	transmembrane transport; heme transporter activity; cellular iron ion homeostasis; heme transport; plasma membrane; transport; ATP binding;
ABCC1	5	transmembrane transport; Golgi apparatus; plasma membrane; transport; ATP binding;

Genes shared at least 2 KEGG pathways with ABCB6 (count: 0)

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Region: chr2:220074490..220083712 View in gBrowse