ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0020037
Name heme binding
Type molecular function
No. of Genes in ADHDgene  28
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 28)

Literature-origin genes (count: 5)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
FADS2 fatty acid desaturase 2 11q12.2 3(3/0/0) IEA
FADS1 fatty acid desaturase 1 11q12-q13.1 3(1/2/0) IEA
TDO2 tryptophan 2,3-dioxygenase 4q31-q32 1(1/0/0) IBA
PGRMC2 progesterone receptor membrane component 2 4q26 1(0/1/0) IEA
NOS1 nitric oxide synthase 1 (neuronal) 12q24.22 1(1/0/0) ISS

Genes from other sources Help (count: 23)

Approved Symbol Approved Name Source Evidence[PMID]
FECH ferrochelatase Mapped by significant region IEA
HBQ1 hemoglobin, theta 1 Mapped by significant region IEA
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mapped by significant region IDA[17006453]
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) Mapped by significant region IEA
HBM hemoglobin, mu Mapped by significant region IEA
FA2H fatty acid 2-hydroxylase Mapped by significant region IEA
AMBP alpha-1-microglobulin/bikunin precursor Mapped by significant region IDA[11877257]
DUOX2 dual oxidase 2 Mapped by CNV IEA
HBA2 hemoglobin, alpha 2 Mapped by significant region IEA
DUOX1 dual oxidase 1 Mapped by CNV IEA
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 Mapped by significant region IEA
CYCS cytochrome c, somatic Mapped by CNV; Mapped by significant region TAS[9515723]
CYB5B cytochrome b5 type B (outer mitochondrial membrane) Mapped by CNV IDA
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 Mapped by LD-proxy IEA
HBG2 hemoglobin, gamma G Mapped by CNV IEA
HBZ hemoglobin, zeta Mapped by significant region IEA
FADS3 fatty acid desaturase 3 Mapped by LD-proxy; Mapped by significant region IEA
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 Mapped by significant region IEA
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV IDA[18818195]
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IEA
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 Mapped by significant region IEA
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein Mapped by significant region ISS
NOX4 NADPH oxidase 4 Mapped by significant region TAS[10869423]