ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0005739
Name mitochondrion
Type cellular component
No. of Genes in ADHDgene  221
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 221)

Literature-origin genes (count: 21)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
TH tyrosine hydroxylase 11p15.5 7(2/5/0) IEA
AS3MT arsenic (+3 oxidation state) methyltransferase 10q24.33 1(1/0/0) IEA
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 7p22 1(0/1/0) IDA
HK1 hexokinase 1 10q22 1(0/1/0) IDA
DNAJC27 DnaJ (Hsp40) homolog, subfamily C, member 27 2p23.3 1(1/0/0) IEA
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0) IEA
MOBP myelin-associated oligodendrocyte basic protein 3p21.33 1(0/0/1) IEA
COMT catechol-O-methyltransferase 22q11.21 29(7/22/0) IEA
KANK2 KN motif and ankyrin repeat domains 2 19p13.2 1(0/1/0) IDA
MTIF3 mitochondrial translational initiation factor 3 13q12.2 1(1/0/0) ISS[12095986]
PARK2 parkin RBR E3 ubiquitin protein ligase 6q25.2-q27 1(1/0/0) IDA; IMP[19029340]
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 3p24.3 1(0/0/1) IEA
ARSB arylsulfatase B 5q14.1 1(0/0/1) IEA
HKDC1 hexokinase domain containing 1 10q22.1 1(0/1/0) IDA
CLYBL citrate lyase beta like 13q32.3 1(0/0/1) IEA
TMEM160 transmembrane protein 160 19q13.32 1(0/1/0) IEA
DISC1 disrupted in schizophrenia 1 1q42.1 1(1/0/0) IDA
NT5DC3 5'-nucleotidase domain containing 3 12q22-q23.1 1(0/0/1) IEA
MTCH2 mitochondrial carrier 2 11p11.2 1(0/1/0) IDA
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2) 12q23 2(2/0/0) IDA
PRELID2 PRELI domain containing 2 5q32 1(0/1/0) IEA

Genes from other sources Help (count: 200)

Approved Symbol Approved Name Source Evidence[PMID]
ACSF3 acyl-CoA synthetase family member 3 Mapped by CNV; Mapped by significant region IDA
PTCD3 pentatricopeptide repeat domain 3 Mapped by CNV IDA[19427859]
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma Mapped by PBA pathway IDA[11278501]
CTU2 cytosolic thiouridylase subunit 2 homolog (S. pombe) Mapped by significant region IDA
MACROD1 MACRO domain containing 1 Mapped by significant region IEA
FAHD1 fumarylacetoacetate hydrolase domain containing 1 Mapped by significant region IDA
FOXRED1 FAD-dependent oxidoreductase domain containing 1 Mapped by significant region IDA
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) Mapped by CNV IDA
HIBADH 3-hydroxyisobutyrate dehydrogenase Mapped by significant region NAS
SGK1 serum/glucocorticoid regulated kinase 1 Mapped by significant region IEA
MTFR2 mitochondrial fission regulator 2 Mapped by significant region ISS
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial Mapped by LD-proxy ISS; NAS[18658143]
NNT nicotinamide nucleotide transhydrogenase Mapped by significant region IDA
THG1L tRNA-histidine guanylyltransferase 1-like (S. cerevisiae) Mapped by significant region IDA
STK11 serine/threonine kinase 11 Mapped by CNV IDA[11430832]
GLYATL1 glycine-N-acyltransferase-like 1 Mapped by significant region IEA
LIPT2 lipoyl(octanoyl) transferase 2 (putative) Mapped by significant region IEA
ACSM2A acyl-CoA synthetase medium-chain family member 2A Mapped by significant region NAS[19634011]
NADK2 NAD kinase 2, mitochondrial Mapped by significant region IDA
HEBP2 heme binding protein 2 Mapped by significant region IEA
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) Mapped by significant region IEA
AMACR alpha-methylacyl-CoA racemase Mapped by significant region IDA[11060344]
MLYCD malonyl-CoA decarboxylase Mapped by CNV; Mapped by significant region IEA
TUFM Tu translation elongation factor, mitochondrial Mapped by LD-proxy IDA
TANGO2 transport and golgi organization 2 homolog (Drosophila) Mapped by CNV IEA
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa Mapped by significant region IDA
MRPL21 mitochondrial ribosomal protein L21 Mapped by CNV; Mapped by significant region IEA
AATK apoptosis-associated tyrosine kinase Mapped by LD-proxy IDA
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) Mapped by PBA pathway IDA
RPUSD4 RNA pseudouridylate synthase domain containing 4 Mapped by significant region IEA
AKAP10 A kinase (PRKA) anchor protein 10 Mapped by significant region IEA
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial Mapped by CNV IDA; TAS[16130169]
MRRF mitochondrial ribosome recycling factor Mapped by significant region IEA
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 Mapped by CNV IDA
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta Mapped by PBA pathway IEA
MRPL16 mitochondrial ribosomal protein L16 Mapped by significant region IEA
CA5A carbonic anhydrase VA, mitochondrial Mapped by significant region TAS[8356065]
FASTK Fas-activated serine/threonine kinase Mapped by Literature SNP IEA
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 Mapped by significant region IEA
BCO2 beta-carotene oxygenase 2 Mapped by significant region ISS; TAS
MRPL50 mitochondrial ribosomal protein L50 Mapped by significant region IEA
SECISBP2 SECIS binding protein 2 Mapped by significant region IEA
FEN1 flap structure-specific endonuclease 1 Mapped by Literature SNP; Mapped by significant region IDA[18995831]
RPS15A ribosomal protein S15a Mapped by significant region IEA
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Mapped by CNV IDA; TAS[9973195]
SRP19 signal recognition particle 19kDa Mapped by LD-proxy IDA
TRAP1 TNF receptor-associated protein 1 Mapped by significant region IEA
PTS 6-pyruvoyltetrahydropterin synthase Mapped by significant region IDA
MTG1 mitochondrial ribosome-associated GTPase 1 Mapped by CNV IDA
FDX1 ferredoxin 1 Mapped by significant region IDA
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV IEA
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 Mapped by LD-proxy IEA
GLYATL2 glycine-N-acyltransferase-like 2 Mapped by significant region IEA
MRPS34 mitochondrial ribosomal protein S34 Mapped by significant region IDA
ALAS1 aminolevulinate, delta-, synthase 1 Mapped by LD-proxy IDA
MAPK1 mitogen-activated protein kinase 1 Mapped by LD-proxy TAS[19565474]
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) Mapped by CNV; Mapped by significant region IEA
RIPK3 receptor-interacting serine-threonine kinase 3 Mapped by significant region IEA
SHMT1 serine hydroxymethyltransferase 1 (soluble) Mapped by significant region IEA
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) Mapped by CNV IEA
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 Mapped by CNV IDA; ISS
GOLPH3 golgi phosphoprotein 3 (coat-protein) Mapped by significant region IDA[16263763]
HSDL2 hydroxysteroid dehydrogenase like 2 Mapped by significant region IEA
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G Mapped by significant region IDA
PON2 paraoxonase 2 Mapped by PBA pathway IEA
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 Mapped by CNV IEA
AGXT2 alanine--glyoxylate aminotransferase 2 Mapped by significant region IDA
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 Mapped by significant region IEA
CCDC90B coiled-coil domain containing 90B Mapped by significant region IDA
MAPK3 mitogen-activated protein kinase 3 Mapped by CNV TAS[19565474]
BAD BCL2-associated agonist of cell death Mapped by significant region IDA
KARS lysyl-tRNA synthetase Mapped by significant region IDA[10952987]
GLUL glutamate-ammonia ligase Mapped by significant region IEA
PYURF PIGY upstream reading frame Mapped by CNV IEA
RAI14 retinoic acid induced 14 Mapped by significant region IEA
NUDT8 nudix (nucleoside diphosphate linked moiety X)-type motif 8 Mapped by significant region IEA
MRPS14 mitochondrial ribosomal protein S14 Mapped by significant region IDA
NME4 NME/NM23 nucleoside diphosphate kinase 4 Mapped by significant region TAS[9099850]
HDDC2 HD domain containing 2 Mapped by significant region IEA
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Mapped by CNV IBA
CCDC136 coiled-coil domain containing 136 Mapped by LD-proxy IEA
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) Mapped by CNV; Mapped by significant region TAS[9180264]
DRG2 developmentally regulated GTP binding protein 2 Mapped by significant region IEA
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like Mapped by significant region IDA[18628306]
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) Mapped by significant region IDA
LYPLA1 lysophospholipase I Mapped by PBA pathway IEA
GLYAT glycine-N-acyltransferase Mapped by LD-proxy; Mapped by significant region ISS
ACACA acetyl-CoA carboxylase alpha Mapped by CNV IEA
TMEM223 transmembrane protein 223 Mapped by significant region IEA
TMEM126A transmembrane protein 126A Mapped by significant region IDA
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region IDA
DNAJC30 DnaJ (Hsp40) homolog, subfamily C, member 30 Mapped by LD-proxy IEA
RAB1B RAB1B, member RAS oncogene family Mapped by significant region IEA
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1 Mapped by LD-proxy ISS
MICU2 mitochondrial calcium uptake 2 Mapped by significant region IEA
NTHL1 nth endonuclease III-like 1 (E. coli) Mapped by significant region IEA
NOX4 NADPH oxidase 4 Mapped by significant region IEA
C22orf29 chromosome 22 open reading frame 29 Mapped by CNV IDA
CHRDL2 chordin-like 2 Mapped by significant region IDA
TXN thioredoxin Mapped by significant region IEA
FIBP fibroblast growth factor (acidic) intracellular binding protein Mapped by significant region TAS[9806903]
CRYAB crystallin, alpha B Mapped by significant region IEA
GLYCTK glycerate kinase Mapped by LD-proxy IEA
PTPMT1 protein tyrosine phosphatase, mitochondrial 1 Mapped by LD-proxy IBA
MRPL28 mitochondrial ribosomal protein L28 Mapped by significant region IDA
NUBPL nucleotide binding protein-like Mapped by significant region IDA[19752196]
GFER growth factor, augmenter of liver regeneration Mapped by significant region IDA
CMC2 C-x(9)-C motif containing 2 Mapped by significant region IDA
FASTKD3 FAST kinase domains 3 Mapped by significant region IDA
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) Mapped by significant region IDA
TMEM186 transmembrane protein 186 Mapped by significant region IDA
DCPS decapping enzyme, scavenger Mapped by significant region IDA
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 Mapped by significant region IDA[15705586]
NARS asparaginyl-tRNA synthetase Mapped by significant region IEA
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 Mapped by CNV IDA
ACSM2B acyl-CoA synthetase medium-chain family member 2B Mapped by significant region NAS[19634011]
CRYM crystallin, mu Mapped by significant region IEA
GSTP1 glutathione S-transferase pi 1 Mapped by significant region IEA
BLID BH3-like motif containing, cell death inducer Mapped by significant region IEA
HINT3 histidine triad nucleotide binding protein 3 Mapped by significant region IDA
CKMT1A creatine kinase, mitochondrial 1A Mapped by LD-proxy TAS[2914937]
GPRC5C G protein-coupled receptor, class C, group 5, member C Mapped by CNV IEA
IREB2 iron-responsive element binding protein 2 Mapped by LD-proxy IEA
ACOT13 acyl-CoA thioesterase 13 Mapped by LD-proxy IEA
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mapped by significant region IDA[10837493]; IDA[18279659]
EMC8 ER membrane protein complex subunit 8 Mapped by significant region IEA
CLPB ClpB caseinolytic peptidase B homolog (E. coli) Mapped by significant region IEA
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 Mapped by CNV IEA
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 Mapped by significant region IEA
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein Mapped by significant region TAS[2302193]
PNKD paroxysmal nonkinesigenic dyskinesia Mapped by significant region IDA
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) Mapped by significant region ISS
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Mapped by significant region IEA
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 Mapped by CNV IDA[16118205]
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) Mapped by significant region TAS[9635427]
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit Mapped by CNV NAS[12887009]
OPA1 optic atrophy 1 (autosomal dominant) Mapped by CNV IDA[17545159]
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial Mapped by significant region TAS[7818469]
MRPS30 mitochondrial ribosomal protein S30 Mapped by significant region IEA
NT5M 5',3'-nucleotidase, mitochondrial Mapped by significant region TAS[10899995]
PERP PERP, TP53 apoptosis effector Mapped by significant region IEA
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IEA
LYRM1 LYR motif containing 1 Mapped by significant region IEA
BCKDK branched chain ketoacid dehydrogenase kinase Mapped by CNV TAS[11839747]
ZDHHC8 zinc finger, DHHC-type containing 8 Mapped by CNV IEA
SLMO1 slowmo homolog 1 (Drosophila) Mapped by CNV IEA
GLT8D1 glycosyltransferase 8 domain containing 1 Mapped by LD-proxy IDA
PC pyruvate carboxylase Mapped by significant region IDA[16729965]
PPM1K protein phosphatase, Mg2+/Mn2+ dependent, 1K Mapped by CNV IDA
GCSH glycine cleavage system protein H (aminomethyl carrier) Mapped by significant region IEA
PPL periplakin Mapped by significant region IEA
SARDH sarcosine dehydrogenase Mapped by LD-proxy ISS
ACAD10 acyl-CoA dehydrogenase family, member 10 Mapped by LD-proxy NAS
C5orf54 chromosome 5 open reading frame 54 Mapped by significant region IEA
FTH1 ferritin, heavy polypeptide 1 Mapped by significant region IEA
TXNRD2 thioredoxin reductase 2 Mapped by Literature SNP; Mapped by CNV IDA
COX4I1 cytochrome c oxidase subunit IV isoform 1 Mapped by significant region IDA
DGAT2 diacylglycerol O-acyltransferase 2 Mapped by significant region ISS
LDHD lactate dehydrogenase D Mapped by significant region ISS
SOD3 superoxide dismutase 3, extracellular Mapped by CNV IBA
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) Mapped by PBA pathway IEA
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 Mapped by PBA pathway IDA
DARS2 aspartyl-tRNA synthetase 2, mitochondrial Mapped by significant region IDA; TAS[15779907]
MALSU1 mitochondrial assembly of ribosomal large subunit 1 Mapped by CNV; Mapped by significant region IDA
SARS seryl-tRNA synthetase Mapped by CNV IEA
EARS2 glutamyl-tRNA synthetase 2, mitochondrial Mapped by significant region IDA[19805282]
TBC1D15 TBC1 domain family, member 15 Mapped by LD-proxy IEA
METTL12 methyltransferase like 12 Mapped by significant region IEA
ZBTB9 zinc finger and BTB domain containing 9 Mapped by LD-proxy IDA
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 Mapped by significant region TAS[11030628]
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 Mapped by CNV IDA
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) Mapped by significant region IDA[7550341]
PICK1 protein interacting with PRKCA 1 Mapped by Literature SNP IEA
PYCARD PYD and CARD domain containing Mapped by CNV IDA[14730312]
TCF25 transcription factor 25 (basic helix-loop-helix) Mapped by significant region IDA
AUH AU RNA binding protein/enoyl-CoA hydratase Mapped by significant region ISS
STAP1 signal transducing adaptor family member 1 Mapped by significant region IDA[17936702]
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 Mapped by PBA pathway IEA
PECR peroxisomal trans-2-enoyl-CoA reductase Mapped by significant region IEA
GHR growth hormone receptor Mapped by CNV; Mapped by significant region IEA
WWOX WW domain containing oxidoreductase Mapped by significant region ISS
FASTKD5 FAST kinase domains 5 Mapped by CNV IDA
UQCRC2 ubiquinol-cytochrome c reductase core protein II Mapped by CNV; Mapped by significant region IDA
ABAT 4-aminobutyrate aminotransferase Mapped by significant region IDA; ISS
POLD3 polymerase (DNA-directed), delta 3, accessory subunit Mapped by significant region IDA
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV IEA
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) Mapped by CNV IDA
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region IDA; NAS[10964512]
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) Mapped by LD-proxy NAS[9647766]
HSDL1 hydroxysteroid dehydrogenase like 1 Mapped by CNV; Mapped by significant region IEA
ACAT1 acetyl-CoA acetyltransferase 1 Mapped by CNV; Mapped by significant region IDA
NME3 NME/NM23 nucleoside diphosphate kinase 3 Mapped by significant region IEA
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) Mapped by CNV; Mapped by significant region IDA[12198123]
SDHAF2 succinate dehydrogenase complex assembly factor 2 Mapped by significant region IDA
TPP1 tripeptidyl peptidase I Mapped by CNV IEA
REXO2 RNA exonuclease 2 Mapped by significant region IDA
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 Mapped by Literature SNP IEA
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 Mapped by significant region IEA
PRDX5 peroxiredoxin 5 Mapped by significant region IDA[10751410]
ACP6 acid phosphatase 6, lysophosphatidic Mapped by CNV IEA