ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KARS
Symbol Alias	KARS2
Approved Name	lysyl-tRNA synthetase
Name Alias	lysine tRNA ligase
Location	16q23.1
Position	chr16:75661622-75681585, -
External Links	HGNC: 6215 Entrez Gene: 3735 Ensembl: ENSG00000065427 UCSC: uc002fer.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000049	tRNA binding	Molecular Function	NAS[10952987]	7
GO:0004824	lysine-tRNA ligase activity	Molecular Function	IDA[10952987]	1
GO:0005524	ATP binding	Molecular Function		228
GO:0005576	extracellular region	Cellular Component		240
GO:0005634	nucleus	Cellular Component		770
GO:0005737	cytoplasm	Cellular Component		690
GO:0005739	mitochondrion	Cellular Component	IDA[10952987]	183
GO:0010467	gene expression	Biological Process		140
GO:0015630	microtubule cytoskeleton	Cellular Component		34
GO:0006430	lysyl-tRNA aminoacylation	Biological Process	IDA[10952987]	1
GO:0008033	tRNA processing	Biological Process	NAS[10952987]	11
GO:0005886	plasma membrane	Cellular Component		772
GO:0006418	tRNA aminoacylation for protein translation	Biological Process		8
GO:0005759	mitochondrial matrix	Cellular Component		32
GO:0005829	cytosol	Cellular Component		447
GO:0046872	metal ion binding	Molecular Function		170
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	Cellular Component		1
GO:0019048	virus-host interaction	Biological Process		54
GO:0015966	diadenosine tetraphosphate biosynthetic process	Biological Process		1
GO:0016597	amino acid binding	Molecular Function		8

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00970	Aminoacyl-tRNA biosynthesis	10

Genes shared at least 5 GO terms with KARS (count: 34)

Gene Symbol	Pathway Count	Pathway List
DARS2	7	tRNA binding; ATP binding; nucleus; mitochondrion; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
MAPK1	7	ATP binding; nucleus; cytoplasm; mitochondrion; microtubule cytoskeleton; cytosol; virus-host interaction;
MAPK3	7	ATP binding; nucleus; mitochondrion; gene expression; microtubule cytoskeleton; cytosol; virus-host interaction;
SARS	7	ATP binding; cytoplasm; mitochondrion; gene expression; tRNA processing; tRNA aminoacylation for protein translation; cytosol;
CRYAB	7	nucleus; cytoplasm; mitochondrion; microtubule cytoskeleton; plasma membrane; cytosol; metal ion binding;
HSPA8	6	ATP binding; nucleus; gene expression; plasma membrane; cytosol; virus-host interaction;
IARS	6	ATP binding; nucleus; cytoplasm; gene expression; tRNA aminoacylation for protein translation; cytosol;
NARS	6	ATP binding; cytoplasm; mitochondrion; gene expression; tRNA aminoacylation for protein translation; cytosol;
PRKD1	6	ATP binding; nucleus; cytoplasm; plasma membrane; cytosol; metal ion binding;
PSMC3	6	ATP binding; nucleus; cytoplasm; gene expression; cytosol; virus-host interaction;
SMG1	6	ATP binding; nucleus; cytoplasm; gene expression; cytosol; metal ion binding;
SNCA	6	extracellular region; nucleus; cytoplasm; mitochondrion; plasma membrane; cytosol;
AIFM3	6	nucleus; cytoplasm; mitochondrion; plasma membrane; cytosol; metal ion binding;
PDE2A	6	nucleus; cytoplasm; plasma membrane; mitochondrial matrix; cytosol; metal ion binding;
THG1L	5	tRNA binding; ATP binding; cytoplasm; mitochondrion; tRNA processing;
DDX23	5	ATP binding; nucleus; mitochondrion; gene expression; plasma membrane;
DGKH	5	ATP binding; nucleus; cytoplasm; plasma membrane; metal ion binding;
EARS2	5	ATP binding; mitochondrion; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
FLT4	5	ATP binding; extracellular region; nucleus; cytoplasm; plasma membrane;
GSK3B	5	ATP binding; nucleus; cytoplasm; plasma membrane; cytosol;
NARS2	5	ATP binding; mitochondrion; gene expression; tRNA aminoacylation for protein translation; mitochondrial matrix;
PRKCB	5	ATP binding; nucleus; cytoplasm; plasma membrane; cytosol;
ROCK2	5	ATP binding; nucleus; plasma membrane; cytosol; metal ion binding;
TARS	5	ATP binding; cytoplasm; gene expression; tRNA aminoacylation for protein translation; cytosol;
PON2	5	extracellular region; nucleus; mitochondrion; plasma membrane; metal ion binding;
PYCARD	5	extracellular region; nucleus; cytoplasm; mitochondrion; cytosol;
ALKBH8	5	nucleus; cytoplasm; microtubule cytoskeleton; cytosol; metal ion binding;
DCPS	5	nucleus; cytoplasm; mitochondrion; gene expression; cytosol;
DGCR8	5	nucleus; cytoplasm; gene expression; microtubule cytoskeleton; metal ion binding;
NEDD4L	5	nucleus; cytoplasm; gene expression; cytosol; virus-host interaction;
SHMT1	5	nucleus; cytoplasm; mitochondrion; cytosol; amino acid binding;
SRP19	5	nucleus; cytoplasm; mitochondrion; gene expression; cytosol;
TH	5	nucleus; cytoplasm; mitochondrion; cytosol; amino acid binding;
WWOX	5	nucleus; cytoplasm; mitochondrion; plasma membrane; cytosol;

Genes shared at least 2 KEGG pathways with KARS (count: 0)

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Region: chr16:75661622..75681585 View in gBrowse