ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IARS
Symbol Alias	ILRS, IARS1
Approved Name	isoleucyl-tRNA synthetase
Name Alias	isoleucine tRNA ligase 1, cytoplasmic
Location	9q21
Position	chr9:94972489-95056038, -
External Links	HGNC: 5330 Entrez Gene: 3376 Ensembl: ENSG00000196305 UCSC: uc004aru.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component		447
GO:0006418	tRNA aminoacylation for protein translation	Biological Process		8
GO:0006428	isoleucyl-tRNA aminoacylation	Biological Process		1
GO:0010467	gene expression	Biological Process		140
GO:0004822	isoleucine-tRNA ligase activity	Molecular Function		1
GO:0002161	aminoacyl-tRNA editing activity	Molecular Function		1
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[9556618]	910
GO:0005730	nucleolus	Cellular Component		243
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00970	Aminoacyl-tRNA biosynthesis	10
hsa00290	Valine, leucine and isoleucine biosynthesis	1

Genes shared at least 5 GO terms with IARS (count: 54)

Gene Symbol	Pathway Count	Pathway List
DCPS	6	cytoplasm; cytosol; gene expression; protein binding; nucleolus; nucleus;
DHX9	6	cytoplasm; gene expression; ATP binding; protein binding; nucleolus; nucleus;
GSK3B	6	cytoplasm; cytosol; ATP binding; protein binding; nucleolus; nucleus;
KARS	6	cytoplasm; cytosol; tRNA aminoacylation for protein translation; gene expression; ATP binding; nucleus;
MAPK1	6	cytoplasm; cytosol; ATP binding; protein binding; nucleolus; nucleus;
MEN1	6	cytoplasm; cytosol; gene expression; protein binding; nucleolus; nucleus;
PSMC3	6	cytoplasm; cytosol; gene expression; ATP binding; protein binding; nucleus;
SMC1A	6	cytoplasm; gene expression; ATP binding; protein binding; nucleolus; nucleus;
SMG1	6	cytoplasm; cytosol; gene expression; ATP binding; protein binding; nucleus;
HSPA8	6	cytosol; gene expression; ATP binding; protein binding; nucleolus; nucleus;
MAPK3	6	cytosol; gene expression; ATP binding; protein binding; nucleolus; nucleus;
AIP	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
ALKBH8	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
BAIAP2	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
CEP164	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
CEP57	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
CHD1L	5	cytoplasm; ATP binding; protein binding; nucleolus; nucleus;
DAXX	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
DGCR8	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
EFTUD2	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
FUS	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
HNRNPA2B1	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
HNRNPH1	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
ID2	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
MALT1	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
NARS	5	cytoplasm; cytosol; tRNA aminoacylation for protein translation; gene expression; ATP binding;
NEDD4L	5	cytoplasm; cytosol; gene expression; protein binding; nucleus;
NUMA1	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
PAFAH1B1	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
PDCD4	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
PGR	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
PPIP5K1	5	cytoplasm; cytosol; ATP binding; nucleolus; nucleus;
PPP1CA	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
PRKCB	5	cytoplasm; cytosol; ATP binding; protein binding; nucleus;
PRKD1	5	cytoplasm; cytosol; ATP binding; protein binding; nucleus;
RBPJ	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
RFWD2	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
RPS3	5	cytoplasm; cytosol; gene expression; protein binding; nucleus;
RPS6KA4	5	cytoplasm; ATP binding; protein binding; nucleolus; nucleus;
RPS9	5	cytoplasm; cytosol; gene expression; protein binding; nucleolus;
SARS	5	cytoplasm; cytosol; tRNA aminoacylation for protein translation; gene expression; ATP binding;
SART1	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
SMG7	5	cytoplasm; cytosol; gene expression; protein binding; nucleus;
SRP19	5	cytoplasm; cytosol; gene expression; nucleolus; nucleus;
SSRP1	5	cytoplasm; gene expression; protein binding; nucleolus; nucleus;
STXBP3	5	cytoplasm; cytosol; protein binding; nucleolus; nucleus;
TARS	5	cytoplasm; cytosol; tRNA aminoacylation for protein translation; gene expression; ATP binding;
XPO1	5	cytoplasm; cytosol; gene expression; protein binding; nucleolus;
XRCC5	5	cytoplasm; ATP binding; protein binding; nucleolus; nucleus;
YAP1	5	cytoplasm; cytosol; gene expression; protein binding; nucleus;
HK1	5	cytosol; ATP binding; protein binding; nucleolus; nucleus;
DARS2	5	tRNA aminoacylation for protein translation; gene expression; ATP binding; protein binding; nucleus;
DDX23	5	gene expression; ATP binding; protein binding; nucleolus; nucleus;
SNRNP200	5	gene expression; ATP binding; protein binding; nucleolus; nucleus;

Genes shared at least 2 KEGG pathways with IARS (count: 0)

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Region: chr9:94972489..95056038 View in gBrowse