ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	BAIAP2
Symbol Alias	BAP2
Approved Name	BAI1-associated protein 2
Location	17q25
Position	chr17:79008948-79091232, 1
External Links	HGNC: 947 Entrez Gene: 10458 Ensembl: ENSG00000175866 UCSC: uc002jzg.2
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin; Mapped by Literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Ribases M, 2009(a)	P-value=0.0026 for single-marker analysis, P-value=0.0016 for multiple-marker analysis in spanish population; P-value=0.0062 in German population. Significant association between BAIAP2 and adulthood ADHD was observed.	Significant

Gene related SNPs (count: 36)

Literature-origin SNPs (count: 13)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs11657991	chr17:79029748(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs7503597	chr17:79049273(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant	1(0/1/0)
rs4969385	chr17:79068890(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(1/0/0)
rs8079781	chr17:79050148(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant	1(1/0/0)
rs8067235	chr17:79024637(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs4075482	chr17:79074548(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs4076037	chr17:79044284(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant	1(0/1/0)
rs8079626	chr17:79026872(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(1/0/0)
rs4969245	chr17:79056453(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs7210438	chr17:79060180(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs11659017	chr17:79018379(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant	1(0/1/0)
rs6565531	chr17:79023380(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs4969349	chr17:79006033(Fwd)	nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 23)

rs_ID	Location	Functional Annotation
rs3934492	chr17:79033964(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs11664	chr17:79082862(Fwd)	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs6565535	chr17:79090448(Fwd)	3_prime_UTR_variant; downstream_gene_variant
rs3935648	chr17:79085335(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4969391	chr17:79089590(Fwd)	3_prime_UTR_variant; downstream_gene_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant
rs8080815	chr17:79059230(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs1801833	chr17:79091353(Fwd)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant
rs4075483	chr17:79074817(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs8071392	chr17:79091103(Fwd)	3_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant
rs4076427	chr17:79087537(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant
rs4969382	chr17:79061083(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4969376	chr17:79052815(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs9901648	chr17:79035708(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4969381	chr17:79054676(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs8066330	chr17:79058278(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4969377	chr17:79053078(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4969380	chr17:79054167(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs11869351	chr17:79026485(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs4969387	chr17:79081724(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; non_coding_exon_variant
rs12601810	chr17:79076230(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs8073904	chr17:79095144(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; NMD_transcript_variant; synonymous_variant; upstream_gene_variant
rs6565532	chr17:79023453(Fwd)	intron_variant; nc_transcript_variant; NMD_transcript_variant; upstream_gene_variant
rs12452150	chr17:79004616(Fwd)	nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 24)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0008022	protein C-terminus binding	molecular function	TAS[10343108]	42
GO:0005730	nucleolus	cellular component	IDA	271
GO:0030054	cell junction	cellular component	IDA	84
GO:0070064	proline-rich region binding	molecular function	IDA[19366662]	5
GO:0030175	filopodium	cellular component	IEA	6
GO:0048167	regulation of synaptic plasticity	biological process	IEA	9
GO:0016358	dendrite development	biological process	IEA	9
GO:0051017	actin filament bundle assembly	biological process	IEA	3
GO:0017124	SH3 domain binding	molecular function	IEA	22
GO:0005829	cytosol	cellular component	IDA[19366662]	485
GO:0046847	filopodium assembly	biological process	IEA	5
GO:0007409	axonogenesis	biological process	TAS[10343108]	15
GO:0005886	plasma membrane	cellular component	IDA	839
GO:0008286	insulin receptor signaling pathway	biological process	TAS[10343108]	37
GO:0043005	neuron projection	cellular component	IEA	38
GO:0015629	actin cytoskeleton	cellular component	IDA[19366662]	30
GO:0005634	nucleus	cellular component	IDA	877
GO:0009617	response to bacterium	biological process	IMP[19366662]	4
GO:0001726	ruffle	cellular component	IEA	16
GO:0032956	regulation of actin cytoskeleton organization	biological process	IMP[19366662]	8
GO:0008093	cytoskeletal adaptor activity	molecular function	IEA	5
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0005515	protein binding	molecular function	IPI[19171758]	1015
GO:0042802	identical protein binding	molecular function	IPI[14752106]	77

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene
hsa04520	Adherens junction	15
hsa05050	Dentatorubropallidoluysian atrophy (DRPLA)	4
hsa04810	Regulation of actin cytoskeleton	49

Genes shared at least 5 GO terms with BAIAP2 (count: 98)

Gene Symbol	Pathway Count	Pathway List
SNCA	8	cell junction; cytosol; plasma membrane; actin cytoskeleton; nucleus; cytoplasm; protein binding; identical protein binding;
AXIN1	7	protein C-terminus binding; cytosol; plasma membrane; nucleus; cytoplasm; protein binding; identical protein binding;
TJP1	7	protein C-terminus binding; cell junction; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
PAK1	7	dendrite development; cytosol; plasma membrane; ruffle; cytoplasm; protein binding; identical protein binding;
BCAR1	7	SH3 domain binding; cytosol; plasma membrane; insulin receptor signaling pathway; ruffle; cytoplasm; protein binding;
STK11	7	cytosol; axonogenesis; insulin receptor signaling pathway; nucleus; cytoplasm; protein binding; identical protein binding;
ATXN1	6	protein C-terminus binding; nucleolus; nucleus; cytoplasm; protein binding; identical protein binding;
SPATA13	6	nucleolus; filopodium; filopodium assembly; nucleus; cytoplasm; protein binding;
MALT1	6	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
STXBP3	6	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
AIP	6	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
MYO10	6	nucleolus; cytosol; plasma membrane; neuron projection; ruffle; cytoplasm;
GSK3B	6	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
SNAP23	6	nucleolus; cell junction; plasma membrane; neuron projection; nucleus; protein binding;
RNF40	6	nucleolus; plasma membrane; neuron projection; nucleus; cytoplasm; protein binding;
SNAP29	6	nucleolus; cell junction; plasma membrane; neuron projection; nucleus; cytoplasm;
PRC1	6	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding; identical protein binding;
MAPK1	6	nucleolus; cytosol; insulin receptor signaling pathway; nucleus; cytoplasm; protein binding;
SHANK2	6	cell junction; SH3 domain binding; plasma membrane; neuron projection; cytoplasm; protein binding;
APBB1	6	proline-rich region binding; axonogenesis; plasma membrane; nucleus; cytoplasm; protein binding;
VIL1	6	filopodium; response to bacterium; ruffle; cytoplasm; protein binding; identical protein binding;
CBL	6	SH3 domain binding; cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
ILK	6	SH3 domain binding; cytosol; plasma membrane; regulation of actin cytoskeleton organization; cytoplasm; protein binding;
APC	6	cytosol; axonogenesis; plasma membrane; nucleus; cytoplasm; protein binding;
WASL	6	cytosol; plasma membrane; actin cytoskeleton; nucleus; response to bacterium; protein binding;
PRKD1	6	cytosol; plasma membrane; nucleus; cytoplasm; protein binding; identical protein binding;
NCK1	6	cytosol; plasma membrane; nucleus; cytoskeletal adaptor activity; cytoplasm; protein binding;
ERBB2	5	protein C-terminus binding; plasma membrane; nucleus; protein binding; identical protein binding;
GOPC	5	protein C-terminus binding; cell junction; plasma membrane; cytoplasm; protein binding;
PRKAA1	5	protein C-terminus binding; cytosol; insulin receptor signaling pathway; nucleus; protein binding;
XRCC5	5	protein C-terminus binding; nucleolus; nucleus; cytoplasm; protein binding;
NCF2	5	protein C-terminus binding; nucleolus; cytosol; cytoplasm; protein binding;
SLC9A3R2	5	protein C-terminus binding; plasma membrane; nucleus; cytoplasm; protein binding;
CORO1A	5	protein C-terminus binding; plasma membrane; nucleus; cytoplasm; protein binding;
ATXN2	5	protein C-terminus binding; nucleolus; nucleus; cytoplasm; protein binding;
AKAP7	5	protein C-terminus binding; cytosol; plasma membrane; nucleus; protein binding;
PICK1	5	protein C-terminus binding; cell junction; plasma membrane; cytoplasm; protein binding;
CEP164	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
HSPA8	5	nucleolus; cytosol; plasma membrane; nucleus; protein binding;
PERP	5	nucleolus; cell junction; plasma membrane; nucleus; cytoplasm;
PARN	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
HMGCS1	5	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm;
PAFAH1B1	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
NF2	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
COG3	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
CEP57	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
CDCA5	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
NUMA1	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
ALKBH8	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
MAPK3	5	nucleolus; cytosol; insulin receptor signaling pathway; nucleus; protein binding;
RAD9A	5	nucleolus; SH3 domain binding; nucleus; cytoplasm; protein binding;
IARS	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
HNRNPH1	5	nucleolus; actin cytoskeleton; nucleus; cytoplasm; protein binding;
RILPL1	5	nucleolus; cytosol; plasma membrane; nucleus; cytoplasm;
CHD1L	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
RRP8	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
PDCD4	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
DCPS	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
PPP1CA	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
MEN1	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
GPSM2	5	nucleolus; nucleus; cytoplasm; protein binding; identical protein binding;
ID2	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
TRIM5	5	nucleolus; nucleus; cytoplasm; protein binding; identical protein binding;
SAP18	5	nucleolus; plasma membrane; nucleus; cytoplasm; protein binding;
SART1	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
KLHL20	5	nucleolus; actin cytoskeleton; nucleus; cytoplasm; protein binding;
DAXX	5	nucleolus; cytosol; nucleus; cytoplasm; protein binding;
ARHGAP32	5	cell junction; cytosol; plasma membrane; actin cytoskeleton; protein binding;
MAP1B	5	cell junction; dendrite development; cytosol; plasma membrane; protein binding;
GRIN2B	5	cell junction; regulation of synaptic plasticity; plasma membrane; neuron projection; protein binding;
GRIN3A	5	cell junction; dendrite development; neuron projection; protein binding; identical protein binding;
DNAJA3	5	cell junction; cytosol; nucleus; cytoplasm; protein binding;
SYT1	5	cell junction; plasma membrane; neuron projection; protein binding; identical protein binding;
AMOTL1	5	cell junction; cytosol; cytoplasm; protein binding; identical protein binding;
SNAP25	5	cell junction; plasma membrane; neuron projection; cytoplasm; protein binding;
YAP1	5	proline-rich region binding; cytosol; nucleus; cytoplasm; protein binding;
RDX	5	filopodium; plasma membrane; ruffle; cytoplasm; protein binding;
PRKG1	5	dendrite development; cytosol; plasma membrane; cytoplasm; protein binding;
PTTG1	5	SH3 domain binding; cytosol; nucleus; cytoplasm; protein binding;
ADAM17	5	SH3 domain binding; plasma membrane; actin cytoskeleton; cytoplasm; protein binding;
INPPL1	5	SH3 domain binding; cytosol; plasma membrane; cytoplasm; protein binding;
FMN1	5	SH3 domain binding; plasma membrane; actin cytoskeleton; nucleus; cytoplasm;
MLST8	5	cytosol; insulin receptor signaling pathway; regulation of actin cytoskeleton organization; cytoplasm; protein binding;
RELA	5	cytosol; nucleus; cytoplasm; protein binding; identical protein binding;
CRYAB	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
WWOX	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
TSC2	5	cytosol; insulin receptor signaling pathway; nucleus; cytoplasm; protein binding;
CTNND1	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
ROCK2	5	cytosol; plasma membrane; nucleus; regulation of actin cytoskeleton organization; protein binding;
ARRB1	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
TH	5	cytosol; neuron projection; nucleus; cytoplasm; protein binding;
MGRN1	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
ARRB2	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
PDE2A	5	cytosol; plasma membrane; nucleus; cytoplasm; protein binding;
MAD1L1	5	cytosol; actin cytoskeleton; nucleus; cytoplasm; protein binding;
CTNNA2	5	cytosol; axonogenesis; actin cytoskeleton; cytoplasm; protein binding;
GRB10	5	cytosol; plasma membrane; insulin receptor signaling pathway; cytoplasm; protein binding;
PDPK1	5	cytosol; plasma membrane; insulin receptor signaling pathway; cytoplasm; protein binding;

Genes shared at least 2 KEGG pathways with BAIAP2 (count: 5)

Gene Symbol	Pathway Count	Pathway List
WASL	2	Adherens junction; Regulation of actin cytoskeleton;
MAPK3	2	Adherens junction; Regulation of actin cytoskeleton;
ACTN3	2	Adherens junction; Regulation of actin cytoskeleton;
MAPK1	2	Adherens junction; Regulation of actin cytoskeleton;
INS	2	Dentatorubropallidoluysian atrophy (DRPLA); Regulation of actin cytoskeleton;

View in gBrowse

Region: chr17:79008948..79091232 View in gBrowse