ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PTTG1
Previous Symbol	TUTR1
Symbol Alias	PTTG, HPTTG, EAP1, securin
Approved Name	pituitary tumor-transforming 1
Name Alias	ESP1-associated protein 1, "tumor-transforming protein 1"
Location	5q35.1
Position	chr5:159848829-159855748, +
External Links	HGNC: 9690 Entrez Gene: 9232 Ensembl: ENSG00000164611 UCSC: uc003lyj.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5q33.3	chr5:155700000-159900000	1 (1/0/0)

Gene related GO terms (count: 17)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[9811450]	132
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005737	cytoplasm	Cellular Component		690
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[12194817]	910
GO:0004869	cysteine-type endopeptidase inhibitor activity	Molecular Function	NAS[12194817]	6
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[9811450]	62
GO:0006355	regulation of transcription, DNA-dependent	Biological Process	TAS[9811450]	158
GO:0006281	DNA repair	Biological Process		62
GO:0005829	cytosol	Cellular Component		447
GO:0017124	SH3 domain binding	Molecular Function		22
GO:0007283	spermatogenesis	Biological Process	TAS[9915854]	35
GO:0007067	mitosis	Biological Process		39
GO:0007059	chromosome segregation	Biological Process		14
GO:0051301	cell division	Biological Process		58
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0051276	chromosome organization	Biological Process		5

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04114	Oocyte meiosis	22	During meiosis, a single round of DNA replication is followe...... During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle. More...

Genes shared at least 5 GO terms with PTTG1 (count: 62)

Gene Symbol	Pathway Count	Pathway List
CEP164	8	mitotic cell cycle; cytoplasm; nucleus; protein binding; DNA repair; cytosol; mitosis; cell division;
CBL	7	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; cytosol; SH3 domain binding;
KIF2C	7	mitotic cell cycle; nucleus; protein binding; cytosol; mitosis; chromosome segregation; cell division;
SMC3	7	mitotic cell cycle; cytoplasm; nucleus; protein binding; DNA repair; mitosis; cell division;
IRF9	6	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; cytosol;
ANAPC4	6	mitotic cell cycle; nucleus; cytosol; mitosis; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
CDC26	6	mitotic cell cycle; protein binding; cytosol; mitosis; cell division; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
CENPC1	6	mitotic cell cycle; cytoplasm; nucleus; cytosol; chromosome segregation; cell division;
CENPW	6	mitotic cell cycle; protein binding; mitosis; chromosome segregation; cell division; chromosome organization;
NUMA1	6	mitotic cell cycle; cytoplasm; nucleus; protein binding; cytosol; cell division;
PLK1	6	mitotic cell cycle; nucleus; protein binding; cytosol; mitosis; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
PSMC3	6	mitotic cell cycle; cytoplasm; nucleus; protein binding; cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
SMC1A	6	mitotic cell cycle; cytoplasm; nucleus; protein binding; DNA repair; cell division;
RCC1	6	cytoplasm; nucleus; protein binding; mitosis; chromosome segregation; cell division;
SSRP1	6	cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; DNA repair;
FOSL1	5	sequence-specific DNA binding transcription factor activity; nucleus; protein binding; transcription from RNA polymerase II promoter; cytosol;
HINFP	5	sequence-specific DNA binding transcription factor activity; nucleus; protein binding; regulation of transcription, DNA-dependent; DNA repair;
HMGA1	5	sequence-specific DNA binding transcription factor activity; nucleus; protein binding; regulation of transcription, DNA-dependent; cytosol;
HSF2	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; transcription from RNA polymerase II promoter; spermatogenesis;
NCOR1	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter;
RELA	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; protein binding; cytosol;
RREB1	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent;
TAF10	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter;
TAF4B	5	sequence-specific DNA binding transcription factor activity; cytoplasm; nucleus; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent;
CCND1	5	mitotic cell cycle; nucleus; protein binding; cytosol; cell division;
CDK5RAP2	5	mitotic cell cycle; cytoplasm; protein binding; cytosol; chromosome segregation;
CEP57	5	mitotic cell cycle; cytoplasm; nucleus; protein binding; cytosol;
CLASP2	5	mitotic cell cycle; cytoplasm; protein binding; cytosol; cell division;
CSNK1E	5	mitotic cell cycle; nucleus; protein binding; DNA repair; cytosol;
MAPRE1	5	mitotic cell cycle; cytoplasm; protein binding; cytosol; cell division;
PAFAH1B1	5	mitotic cell cycle; cytoplasm; nucleus; protein binding; cytosol;
UBB	5	mitotic cell cycle; protein binding; DNA repair; cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
UBC	5	mitotic cell cycle; protein binding; DNA repair; cytosol; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
ZW10	5	mitotic cell cycle; nucleus; protein binding; cytosol; cell division;
APC	5	cytoplasm; nucleus; protein binding; cytosol; chromosome organization;
ARRB1	5	cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; cytosol;
ARRB2	5	cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; cytosol;
BAIAP2	5	cytoplasm; nucleus; protein binding; cytosol; SH3 domain binding;
BCAR1	5	cytoplasm; protein binding; cytosol; SH3 domain binding; cell division;
CDCA5	5	cytoplasm; nucleus; protein binding; mitosis; cell division;
CTNND1	5	cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; cytosol;
DAXX	5	cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; cytosol;
FANCC	5	cytoplasm; nucleus; protein binding; DNA repair; cytosol;
HABP4	5	cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; cytosol;
HERC2	5	cytoplasm; nucleus; protein binding; DNA repair; spermatogenesis;
IGHMBP2	5	cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; DNA repair;
IRF7	5	cytoplasm; nucleus; protein binding; transcription from RNA polymerase II promoter; cytosol;
KIF22	5	cytoplasm; nucleus; DNA repair; cytosol; mitosis;
MEN1	5	cytoplasm; nucleus; protein binding; DNA repair; cytosol;
MMS19	5	cytoplasm; nucleus; protein binding; DNA repair; chromosome segregation;
NDNL2	5	cytoplasm; nucleus; protein binding; regulation of transcription, DNA-dependent; DNA repair;
NEK6	5	cytoplasm; nucleus; protein binding; mitosis; chromosome segregation;
PPP1CA	5	cytoplasm; nucleus; protein binding; cytosol; cell division;
RAD23B	5	cytoplasm; nucleus; protein binding; DNA repair; spermatogenesis;
RAD9A	5	cytoplasm; nucleus; protein binding; DNA repair; SH3 domain binding;
RAN	5	cytoplasm; protein binding; cytosol; mitosis; cell division;
SKA3	5	cytoplasm; protein binding; mitosis; chromosome segregation; cell division;
SMC2	5	cytoplasm; nucleus; protein binding; DNA repair; cell division;
SMG1	5	cytoplasm; nucleus; protein binding; DNA repair; cytosol;
LATS2	5	nucleus; protein binding; cytosol; mitosis; cell division;
NFRKB	5	nucleus; protein binding; transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; DNA repair;
RBBP8	5	nucleus; protein binding; DNA repair; mitosis; cell division;

Genes shared at least 2 KEGG pathways with PTTG1 (count: 7)

Gene Symbol	Pathway Count	Pathway List
ANAPC4	2	Cell cycle; Oocyte meiosis;
CDC26	2	Cell cycle; Oocyte meiosis;
PLK1	2	Cell cycle; Oocyte meiosis;
SMC1A	2	Cell cycle; Oocyte meiosis;
SMC3	2	Cell cycle; Oocyte meiosis;
YWHAH	2	Cell cycle; Oocyte meiosis;
YWHAQ	2	Cell cycle; Oocyte meiosis;

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Region: chr5:159848829..159855748 View in gBrowse