ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	YWHAH
Previous Symbol	YWHA1
Approved Name	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
Name Alias	14-3-3 eta
Location	22q12.1-q13.1
Position	chr22:32340447-32353590, +
External Links	HGNC: 12853 Entrez Gene: 7533 Ensembl: ENSG00000128245 UCSC: uc003alz.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 20)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0019904	protein domain specific binding	Molecular Function		40
GO:0019899	enzyme binding	Molecular Function	IPI[17255105]	47
GO:0017080	sodium channel regulator activity	Molecular Function		7
GO:0014704	intercalated disc	Cellular Component	IC[16728661]	10
GO:0006886	intracellular protein transport	Biological Process		43
GO:0006713	glucocorticoid catabolic process	Biological Process	IDA[15790729]	1
GO:0005737	cytoplasm	Cellular Component		690
GO:0005515	protein binding	Molecular Function		910
GO:0050774	negative regulation of dendrite morphogenesis	Biological Process		2
GO:0048167	regulation of synaptic plasticity	Biological Process		9
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[15790729]	80
GO:0045664	regulation of neuron differentiation	Biological Process		4
GO:0044325	ion channel binding	Molecular Function		15
GO:0042921	glucocorticoid receptor signaling pathway	Biological Process	IDA[15790729]	3
GO:0035259	glucocorticoid receptor binding	Molecular Function	IPI[9079630]	2
GO:0002028	regulation of sodium ion transport	Biological Process		4
GO:2000649	regulation of sodium ion transmembrane transporter activity	Biological Process		5
GO:0005159	insulin-like growth factor receptor binding	Molecular Function		5
GO:0003779	actin binding	Molecular Function		46

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04114	Oocyte meiosis	22	During meiosis, a single round of DNA replication is followe...... During meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segregate to opposite poles, while the sister chromatids segregate from each other at meoisis II. In vertebrates, immature oocytes are arrested at the PI (prophase of meiosis I). The resumption of meiosis is stimulated by progesterone, which carries the oocyte through two consecutive M-phases (MI and MII) to a second arrest at MII. The key activity driving meiotic progression is the MPF (maturation-promoting factor), a heterodimer of CDC2 (cell division cycle 2 kinase) and cyclin B. In PI-arrested oocytes, MPF is initially inactive and is activated by the dual-specificity CDC25C phosphatase as the result of new synthesis of Mos induced by progesterone. MPF activation mediates the transition from the PI arrest to MI. The subsequent decrease in MPF levels, required to exit from MI into interkinesis, is induced by a negative feedback loop, where CDC2 brings about the activation of the APC (anaphase-promoting complex), which mediates destruction of cyclin B. Re-activation of MPF for MII requires re-accumulation of high levels of cyclin B as well as the inactivation of the APC by newly synthesized Emi2 and other components of the CSF (cytostatic factor), such as cyclin E or high levels of Mos. CSF antagonizes the ubiquitin ligase activity of the APC, preventing cyclin B destruction and meiotic exit until fertilization occurs. Fertilization triggers a transient increase in cytosolic free Ca2+, which leads to CSF inactivation and cyclin B destruction through the APC. Then eggs are released from MII into the first embryonic cell cycle. More...
hsa04722	Neurotrophin signaling pathway	24	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...

Genes shared at least 5 GO terms with YWHAH (count: 1)

Gene Symbol	Pathway Count	Pathway List
NCOA6	5	enzyme binding; protein binding; positive regulation of transcription, DNA-dependent; glucocorticoid receptor signaling pathway; nuclear hormone receptor binding;

Genes shared at least 2 KEGG pathways with YWHAH (count: 11)

Gene Symbol	Pathway Count	Pathway List
YWHAQ	3	Cell cycle; Oocyte meiosis; Neurotrophin signaling pathway;
ANAPC4	2	Cell cycle; Oocyte meiosis;
CDC26	2	Cell cycle; Oocyte meiosis;
GSK3B	2	Cell cycle; Neurotrophin signaling pathway;
PLK1	2	Cell cycle; Oocyte meiosis;
PTTG1	2	Cell cycle; Oocyte meiosis;
SMC1A	2	Cell cycle; Oocyte meiosis;
SMC3	2	Cell cycle; Oocyte meiosis;
CAMK2D	2	Oocyte meiosis; Neurotrophin signaling pathway;
MAPK1	2	Oocyte meiosis; Neurotrophin signaling pathway;
MAPK3	2	Oocyte meiosis; Neurotrophin signaling pathway;

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Region: chr22:32340447..32353590 View in gBrowse