ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RAN
Symbol Alias	ARA24, TC4, Gsp1
Approved Name	RAN, member RAS oncogene family
Location	12
Position	chr12:131356568-131362223, +
External Links	HGNC: 9846 Entrez Gene: 5901 Ensembl: ENSG00000132341 UCSC: uc001uir.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005525	GTP binding	Molecular Function	IDA[1961752]	53
GO:0005643	nuclear pore	Cellular Component	NAS[8421051]	9
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component	IDA[1961752]	690
GO:0003682	chromatin binding	Molecular Function	TAS[1961752]	48
GO:0003713	transcription coactivator activity	Molecular Function	NAS[15572661]	52
GO:0003924	GTPase activity	Molecular Function	TAS[10400640]	41
GO:0005515	protein binding	Molecular Function	IPI[18617507]	910
GO:0000785	chromatin	Cellular Component	IDA[1961752]	13
GO:0032092	positive regulation of protein binding	Biological Process	IDA[16449645]	4
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS[15572661]	16
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	NAS[15572661]	80
GO:0042470	melanosome	Cellular Component		22
GO:0016032	viral reproduction	Biological Process		57
GO:0010467	gene expression	Biological Process		140
GO:0019058	viral infectious cycle	Biological Process		15
GO:0019048	virus-host interaction	Biological Process		54
GO:0007067	mitosis	Biological Process	TAS[8421051]	39
GO:0007052	mitotic spindle organization	Biological Process	TAS[10408446]	7
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0007165	signal transduction	Biological Process	TAS[7603572]	171
GO:0006259	DNA metabolic process	Biological Process	TAS[8421051]	4
GO:0005829	cytosol	Cellular Component		447
GO:0006611	protein export from nucleus	Biological Process	IDA[16449645]	4
GO:0006405	RNA export from nucleus	Biological Process		2
GO:0051301	cell division	Biological Process		58
GO:0050681	androgen receptor binding	Molecular Function	NAS[15572661]	10

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03008	Ribosome biogenesis in eukaryotes	12	Ribosomes are the cellular factories responsible for making ...... Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage. More...
hsa03013	RNA transport	15	RNA transport from the nucleus to the cytoplasm is fundamen...... RNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) via mobile export receptors. The majority of RNAs, such as tRNAs, rRNAs, and U snRNAs, are transported by specific export receptors, which belong to the karyopherin-beta family proteins. A feature of karyopherins is their regulation by the small GTPase Ran. However, general mRNA export is mechanistically different. Nuclear export of mRNAs is functionally coupled to different steps in gene expression processes, such as transcription, splicing, 3'-end formation and even translation. More...

Genes shared at least 5 GO terms with RAN (count: 86)

Gene Symbol	Pathway Count	Pathway List
XPO1	10	nuclear pore; nucleoplasm; cytoplasm; protein binding; viral reproduction; gene expression; viral infectious cycle; virus-host interaction; cytosol; protein export from nucleus;
SMC3	10	nucleoplasm; cytoplasm; chromatin binding; protein binding; microtubule cytoskeleton organization; chromatin; mitosis; mitotic spindle organization; signal transduction; cell division;
RCC1	9	nucleoplasm; cytoplasm; chromatin binding; protein binding; microtubule cytoskeleton organization; viral reproduction; mitosis; mitotic spindle organization; cell division;
MAPK1	8	nucleoplasm; cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; virus-host interaction; small GTPase mediated signal transduction; signal transduction; cytosol;
MEN1	8	nucleoplasm; cytoplasm; chromatin binding; protein binding; chromatin; positive regulation of protein binding; gene expression; cytosol;
PSMC3	8	nucleoplasm; cytoplasm; transcription coactivator activity; protein binding; viral reproduction; gene expression; virus-host interaction; cytosol;
SMC1A	8	nucleoplasm; cytoplasm; chromatin binding; protein binding; microtubule cytoskeleton organization; gene expression; mitotic spindle organization; cell division;
KAT5	8	transcription coactivator activity; protein binding; chromatin; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; virus-host interaction; cytosol; androgen receptor binding;
MED1	7	nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
RELA	7	nucleoplasm; cytoplasm; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; virus-host interaction; cytosol;
YAP1	7	nucleoplasm; cytoplasm; chromatin binding; transcription coactivator activity; protein binding; gene expression; cytosol;
EFTUD2	6	GTP binding; nucleoplasm; cytoplasm; GTPase activity; protein binding; gene expression;
TUBG1	6	GTP binding; cytoplasm; GTPase activity; protein binding; microtubule cytoskeleton organization; cytosol;
NUP62	6	nuclear pore; cytoplasm; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; viral reproduction;
NXF1	6	nuclear pore; nucleoplasm; protein binding; gene expression; virus-host interaction; cytosol;
HMGA1	6	nucleoplasm; protein binding; positive regulation of transcription, DNA-dependent; viral reproduction; virus-host interaction; cytosol;
MAPK3	6	nucleoplasm; protein binding; gene expression; virus-host interaction; small GTPase mediated signal transduction; cytosol;
MED12	6	nucleoplasm; chromatin binding; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
NEDD4L	6	nucleoplasm; cytoplasm; protein binding; gene expression; virus-host interaction; cytosol;
PSMB7	6	nucleoplasm; protein binding; viral reproduction; gene expression; virus-host interaction; cytosol;
SNW1	6	nucleoplasm; transcription coactivator activity; protein binding; chromatin; gene expression; virus-host interaction;
SSRP1	6	nucleoplasm; cytoplasm; chromatin binding; protein binding; viral reproduction; gene expression;
TAF10	6	nucleoplasm; cytoplasm; transcription coactivator activity; protein binding; viral reproduction; gene expression;
TCEB1	6	nucleoplasm; protein binding; viral reproduction; gene expression; virus-host interaction; cytosol;
DAXX	6	cytoplasm; protein binding; androgen receptor signaling pathway; virus-host interaction; cytosol; androgen receptor binding;
KIF11	6	cytoplasm; microtubule cytoskeleton organization; mitosis; mitotic spindle organization; cytosol; cell division;
PRKCB	6	cytoplasm; chromatin binding; protein binding; signal transduction; cytosol; androgen receptor binding;
RPL14	6	cytoplasm; protein binding; viral reproduction; gene expression; viral infectious cycle; cytosol;
RPS3	6	cytoplasm; protein binding; viral reproduction; gene expression; viral infectious cycle; cytosol;
RPS9	6	cytoplasm; protein binding; viral reproduction; gene expression; viral infectious cycle; cytosol;
TGFB1I1	6	cytoplasm; transcription coactivator activity; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; androgen receptor binding;
UBE3A	6	cytoplasm; transcription coactivator activity; protein binding; androgen receptor signaling pathway; virus-host interaction; cytosol;
ARHGEF2	6	protein binding; microtubule cytoskeleton organization; mitosis; small GTPase mediated signal transduction; cytosol; cell division;
ARHGAP5	5	GTP binding; cytoplasm; GTPase activity; small GTPase mediated signal transduction; cytosol;
EIF2B1	5	GTP binding; cytoplasm; protein binding; gene expression; cytosol;
RAB14	5	GTP binding; GTPase activity; protein binding; small GTPase mediated signal transduction; cytosol;
RAB27A	5	GTP binding; GTPase activity; protein binding; melanosome; small GTPase mediated signal transduction;
RAB6A	5	GTP binding; GTPase activity; protein binding; small GTPase mediated signal transduction; cytosol;
BANF1	5	nucleoplasm; protein binding; viral reproduction; virus-host interaction; cytosol;
CDC26	5	nucleoplasm; protein binding; mitosis; cytosol; cell division;
HINFP	5	nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
HNRNPA1	5	nucleoplasm; cytoplasm; gene expression; virus-host interaction; RNA export from nucleus;
IRF7	5	nucleoplasm; cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; cytosol;
MAP2K3	5	nucleoplasm; protein binding; positive regulation of transcription, DNA-dependent; signal transduction; cytosol;
MED13	5	nucleoplasm; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
MED14	5	nucleoplasm; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
MED16	5	nucleoplasm; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
MED17	5	nucleoplasm; transcription coactivator activity; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
MED30	5	nucleoplasm; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
MED4	5	nucleoplasm; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; gene expression;
NCBP1	5	nucleoplasm; protein binding; viral reproduction; gene expression; cytosol;
NCOA6	5	nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
NCOR1	5	nucleoplasm; cytoplasm; chromatin binding; protein binding; gene expression;
NR4A2	5	nucleoplasm; cytoplasm; protein binding; gene expression; signal transduction;
NR5A1	5	nucleoplasm; chromatin binding; transcription coactivator activity; protein binding; gene expression;
NUMA1	5	nucleoplasm; cytoplasm; protein binding; cytosol; cell division;
PGR	5	nucleoplasm; cytoplasm; protein binding; gene expression; signal transduction;
PRPF6	5	nucleoplasm; transcription coactivator activity; protein binding; gene expression; androgen receptor binding;
PSMD5	5	nucleoplasm; protein binding; viral reproduction; gene expression; cytosol;
PSMD7	5	nucleoplasm; protein binding; viral reproduction; gene expression; cytosol;
PSME1	5	nucleoplasm; cytoplasm; viral reproduction; gene expression; cytosol;
SMARCD3	5	nucleoplasm; cytoplasm; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
TXNL4A	5	nucleoplasm; protein binding; gene expression; mitosis; cell division;
UBB	5	nucleoplasm; protein binding; viral reproduction; gene expression; cytosol;
UBC	5	nucleoplasm; protein binding; viral reproduction; gene expression; cytosol;
AIP	5	cytoplasm; transcription coactivator activity; protein binding; signal transduction; cytosol;
APBB1	5	cytoplasm; chromatin binding; protein binding; positive regulation of transcription, DNA-dependent; signal transduction;
ARRB1	5	cytoplasm; protein binding; chromatin; positive regulation of protein binding; cytosol;
CDCA5	5	cytoplasm; chromatin binding; protein binding; mitosis; cell division;
CDK5RAP2	5	cytoplasm; protein binding; microtubule cytoskeleton organization; positive regulation of transcription, DNA-dependent; cytosol;
CEP164	5	cytoplasm; protein binding; mitosis; cytosol; cell division;
CLASP2	5	cytoplasm; protein binding; microtubule cytoskeleton organization; cytosol; cell division;
GSK3B	5	cytoplasm; protein binding; positive regulation of protein binding; cytosol; protein export from nucleus;
ID2	5	cytoplasm; protein binding; chromatin; positive regulation of transcription, DNA-dependent; cytosol;
MAPRE1	5	cytoplasm; protein binding; microtubule cytoskeleton organization; cytosol; cell division;
MMS19	5	cytoplasm; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent; DNA metabolic process;
PSRC1	5	cytoplasm; protein binding; positive regulation of transcription, DNA-dependent; cytosol; cell division;
PTTG1	5	cytoplasm; protein binding; mitosis; cytosol; cell division;
RPL35	5	cytoplasm; viral reproduction; gene expression; viral infectious cycle; cytosol;
RPS15A	5	cytoplasm; viral reproduction; gene expression; viral infectious cycle; cytosol;
RPS25	5	cytoplasm; viral reproduction; gene expression; viral infectious cycle; cytosol;
TFAP2A	5	cytoplasm; chromatin binding; transcription coactivator activity; protein binding; positive regulation of transcription, DNA-dependent;
NRIP1	5	transcription coactivator activity; protein binding; androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; androgen receptor binding;
HSPA8	5	protein binding; melanosome; gene expression; virus-host interaction; cytosol;
KIF2C	5	protein binding; microtubule cytoskeleton organization; mitosis; cytosol; cell division;
RPL13	5	protein binding; viral reproduction; gene expression; viral infectious cycle; cytosol;

Genes shared at least 2 KEGG pathways with RAN (count: 5)

Gene Symbol	Pathway Count	Pathway List
C9orf23	2	Ribosome biogenesis in eukaryotes; RNA transport;
NMD3	2	Ribosome biogenesis in eukaryotes; RNA transport;
NXF1	2	Ribosome biogenesis in eukaryotes; RNA transport;
RPP30	2	Ribosome biogenesis in eukaryotes; RNA transport;
XPO1	2	Ribosome biogenesis in eukaryotes; RNA transport;

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Region: chr12:131356568..131362223 View in gBrowse