ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARHGAP5
Previous Symbol	GFI2
Symbol Alias	RhoGAP5, p190-B, p190BRhoGAP
Approved Name	Rho GTPase activating protein 5
Previous Name	"growth factor independent 2"
Location	14q12
Position	chr14:32545320-32628934, 1
External Links	HGNC: 675 Entrez Gene: 394 Ensembl: ENSG00000100852 UCSC: uc001wrn.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005100	Rho GTPase activator activity	molecular function	TAS[8537347]	6
GO:0042169	SH2 domain binding	molecular function	IPI[1689011]	8
GO:0008361	regulation of cell size	biological process	IEA	3
GO:0030335	positive regulation of cell migration	biological process	IEA	28
GO:0016020	membrane	cellular component	IEA	155
GO:0005829	cytosol	cellular component	TAS	485
GO:0051056	regulation of small GTPase mediated signal transduction	biological process	TAS	32
GO:0005525	GTP binding	molecular function	IEA	64
GO:0007266	Rho protein signal transduction	biological process	TAS[8537347]	12
GO:0032321	positive regulation of Rho GTPase activity	biological process	TAS[8537347]	6
GO:0007155	cell adhesion	biological process	TAS[8537347]	99
GO:0002053	positive regulation of mesenchymal cell proliferation	biological process	IEA	9
GO:0007264	small GTPase mediated signal transduction	biological process	TAS	65
GO:0006184	GTP catabolic process	biological process	TAS[8537347]	24
GO:0005737	cytoplasm	cellular component	TAS[8537347]	781
GO:0003924	GTPase activity	molecular function	TAS[8537347]	46

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04670	Leukocyte transendothelial migration	23
hsa04510	Focal adhesion	40

Genes shared at least 5 GO terms with ARHGAP5 (count: 13)

Gene Symbol	Pathway Count	Pathway List
RHOD	7	cytosol; regulation of small GTPase mediated signal transduction; GTP binding; Rho protein signal transduction; small GTPase mediated signal transduction; GTP catabolic process; GTPase activity;
RAB6A	6	membrane; cytosol; GTP binding; small GTPase mediated signal transduction; GTP catabolic process; GTPase activity;
ARF6	6	membrane; GTP binding; cell adhesion; small GTPase mediated signal transduction; GTP catabolic process; GTPase activity;
SRGAP1	5	Rho GTPase activator activity; cytosol; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction;
ARHGAP8	5	Rho GTPase activator activity; cytosol; regulation of small GTPase mediated signal transduction; positive regulation of Rho GTPase activity; small GTPase mediated signal transduction;
RAB30	5	membrane; GTP binding; small GTPase mediated signal transduction; GTP catabolic process; GTPase activity;
AGAP3	5	membrane; GTP binding; small GTPase mediated signal transduction; cytoplasm; GTPase activity;
ARHGEF12	5	membrane; cytosol; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; cytoplasm;
ARHGDIG	5	membrane; cytosol; regulation of small GTPase mediated signal transduction; Rho protein signal transduction; small GTPase mediated signal transduction;
RAB14	5	cytosol; GTP binding; small GTPase mediated signal transduction; GTP catabolic process; GTPase activity;
RAN	5	cytosol; GTP binding; small GTPase mediated signal transduction; cytoplasm; GTPase activity;
RHOT2	5	cytosol; regulation of small GTPase mediated signal transduction; GTP binding; small GTPase mediated signal transduction; GTPase activity;
RAB6C	5	GTP binding; small GTPase mediated signal transduction; GTP catabolic process; cytoplasm; GTPase activity;

Genes shared at least 2 KEGG pathways with ARHGAP5 (count: 6)

Gene Symbol	Pathway Count	Pathway List
PIK3R1	2	Leukocyte transendothelial migration; Focal adhesion;
MYLPF	2	Leukocyte transendothelial migration; Focal adhesion;
ACTN3	2	Leukocyte transendothelial migration; Focal adhesion;
ROCK2	2	Leukocyte transendothelial migration; Focal adhesion;
BCAR1	2	Leukocyte transendothelial migration; Focal adhesion;
PIK3CG	2	Leukocyte transendothelial migration; Focal adhesion;

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Region: chr14:32545320..32628934 View in gBrowse