ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ARHGAP5
Previous Symbol	GFI2
Symbol Alias	RhoGAP5, p190-B, p190BRhoGAP
Approved Name	Rho GTPase activating protein 5
Previous Name	growth factor independent 2
Location	14q12
Position	chr14:32546495-32628934, +
External Links	HGNC: 675 Entrez Gene: 394 Ensembl: ENSG00000100852 UCSC: uc001wrn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
14q12	chr14:24600000-33300000	1 (1/0/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051056	regulation of small GTPase mediated signal transduction	Biological Process		30
GO:0016020	membrane	Cellular Component		139
GO:0030335	positive regulation of cell migration	Biological Process		29
GO:0032321	positive regulation of Rho GTPase activity	Biological Process	TAS[8537347]	6
GO:0042169	SH2 domain binding	Molecular Function	IPI[1689011]	7
GO:0007264	small GTPase mediated signal transduction	Biological Process		58
GO:0007155	cell adhesion	Biological Process	TAS[8537347]	86
GO:0008361	regulation of cell size	Biological Process		3
GO:0007266	Rho protein signal transduction	Biological Process	TAS[8537347]	11
GO:0005737	cytoplasm	Cellular Component	TAS[8537347]	690
GO:0005525	GTP binding	Molecular Function		53
GO:0006184	GTP catabolic process	Biological Process	TAS[8537347]	22
GO:0005829	cytosol	Cellular Component		447
GO:0002053	positive regulation of mesenchymal cell proliferation	Biological Process		9
GO:0005100	Rho GTPase activator activity	Molecular Function	TAS[8537347]	6
GO:0003924	GTPase activity	Molecular Function	TAS[8537347]	41

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04510	Focal adhesion	40	Cell-matrix adhesions play essential roles in important biol...... Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling. More...
hsa04670	Leukocyte transendothelial migration	22	Leukocyte migaration from the blood into tissues is vital fo...... Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the "endothelial passage" through which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion. More...

Genes shared at least 5 GO terms with ARHGAP5 (count: 11)

Gene Symbol	Pathway Count	Pathway List
RHOD	7	regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; Rho protein signal transduction; GTP binding; GTP catabolic process; cytosol; GTPase activity;
ARF6	6	membrane; small GTPase mediated signal transduction; cell adhesion; GTP binding; GTP catabolic process; GTPase activity;
RAB6A	6	membrane; small GTPase mediated signal transduction; GTP binding; GTP catabolic process; cytosol; GTPase activity;
ARHGAP8	5	regulation of small GTPase mediated signal transduction; positive regulation of Rho GTPase activity; small GTPase mediated signal transduction; cytosol; Rho GTPase activator activity;
ARHGEF12	5	regulation of small GTPase mediated signal transduction; membrane; small GTPase mediated signal transduction; cytoplasm; cytosol;
SRGAP1	5	regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; Rho protein signal transduction; cytosol; Rho GTPase activator activity;
AGAP3	5	membrane; small GTPase mediated signal transduction; cytoplasm; GTP binding; GTPase activity;
RAB30	5	membrane; small GTPase mediated signal transduction; GTP binding; GTP catabolic process; GTPase activity;
RAB14	5	small GTPase mediated signal transduction; GTP binding; GTP catabolic process; cytosol; GTPase activity;
RAB6C	5	small GTPase mediated signal transduction; cytoplasm; GTP binding; GTP catabolic process; GTPase activity;
RAN	5	small GTPase mediated signal transduction; cytoplasm; GTP binding; cytosol; GTPase activity;

Genes shared at least 2 KEGG pathways with ARHGAP5 (count: 7)

Gene Symbol	Pathway Count	Pathway List
ACTN3	2	Focal adhesion; Leukocyte transendothelial migration;
BCAR1	2	Focal adhesion; Leukocyte transendothelial migration;
MYLPF	2	Focal adhesion; Leukocyte transendothelial migration;
PIK3CG	2	Focal adhesion; Leukocyte transendothelial migration;
PIK3R1	2	Focal adhesion; Leukocyte transendothelial migration;
PRKCB	2	Focal adhesion; Leukocyte transendothelial migration;
ROCK2	2	Focal adhesion; Leukocyte transendothelial migration;

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Region: chr14:32546495..32628934 View in gBrowse