ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	MED14
Previous Symbol	CXorf4, CRSP2
Symbol Alias	EXLM1, CRSP150, TRAP170, RGR1, CSRP
Approved Name	mediator complex subunit 14
Previous Name	cofactor required for Sp1 transcriptional activation, subunit 2, 150kDa
Location	Xp11.4
Position	chrX:40507558-40595110, -
External Links	HGNC: 2370 Entrez Gene: 9282 Ensembl: ENSG00000180182 UCSC: uc004dex.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[12037571]	131
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10198638]	80
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[10198638]	18
GO:0030521	androgen receptor signaling pathway	Biological Process	IDA[12218053]	16
GO:0030518	intracellular steroid hormone receptor signaling pathway	Biological Process	IDA[11867769]	10
GO:0042809	vitamin D receptor binding	Molecular Function	NAS[10235266]	11
GO:0001104	RNA polymerase II transcription cofactor activity	Molecular Function	IDA[10198638]	16
GO:0003712	transcription cofactor activity	Molecular Function	IDA[12218053]	17
GO:0003713	transcription coactivator activity	Molecular Function	IDA[12037571]	52
GO:0004872	receptor activity	Molecular Function	IDA[12218053]	36
GO:0010467	gene expression	Biological Process		140
GO:0016592	mediator complex	Cellular Component	IDA[10198638]	17
GO:0019827	stem cell maintenance	Biological Process		12
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity	Molecular Function	NAS[10235266]	19
GO:0005634	nucleus	Cellular Component	IDA[10235267]	770
GO:0005654	nucleoplasm	Cellular Component		183
GO:0006357	regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[9989412]	42
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process	IDA[12218053]	42

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with MED14 (count: 36)

Gene Symbol	Pathway Count	Pathway List
MED17	19	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription coactivator activity; receptor activity; gene expression; mediator complex; stem cell maintenance; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
MED12	18	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription coactivator activity; receptor activity; gene expression; mediator complex; stem cell maintenance; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED1	17	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription coactivator activity; receptor activity; gene expression; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED13	17	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription coactivator activity; receptor activity; gene expression; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED24	16	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; receptor activity; gene expression; mediator complex; stem cell maintenance; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED30	16	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; receptor activity; gene expression; mediator complex; stem cell maintenance; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
THRAP3	15	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; transcription coactivator activity; receptor activity; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; transcription initiation from RNA polymerase II promoter;
MED16	15	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; transcription cofactor activity; transcription coactivator activity; receptor activity; gene expression; mediator complex; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
MED4	15	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; androgen receptor signaling pathway; intracellular steroid hormone receptor signaling pathway; vitamin D receptor binding; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; transcription cofactor activity; receptor activity; gene expression; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NCOA6	9	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding; transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
SNW1	9	positive regulation of transcription from RNA polymerase II promoter; vitamin D receptor binding; nuclear hormone receptor binding; transcription coactivator activity; gene expression; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
MED7	8	RNA polymerase II transcription cofactor activity; transcription coactivator activity; gene expression; mediator complex; stem cell maintenance; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
SMARCD3	7	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; transcription coactivator activity; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter;
MED15	7	RNA polymerase II transcription cofactor activity; gene expression; mediator complex; stem cell maintenance; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MAML1	6	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MAML2	6	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR5A1	6	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NRIP1	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; nuclear hormone receptor binding; transcription coactivator activity; nucleus;
PPARGC1B	6	positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; RNA polymerase II transcription cofactor activity; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus;
PRPF6	6	positive regulation of transcription from RNA polymerase II promoter; nuclear hormone receptor binding; transcription coactivator activity; gene expression; nucleus; nucleoplasm;
YAP1	6	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
MED23	6	transcription coactivator activity; gene expression; mediator complex; nucleoplasm; regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter;
ESRRA	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
KAT5	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; nucleus;
KDM1A	5	positive regulation of transcription from RNA polymerase II promoter; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter;
MEN1	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
NR4A2	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
RBM14	5	positive regulation of transcription from RNA polymerase II promoter; RNA polymerase II transcription cofactor activity; mediator complex; ligand-dependent nuclear receptor transcription coactivator activity; nucleus;
RBPJ	5	positive regulation of transcription from RNA polymerase II promoter; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; transcription coactivator activity; nucleus; nucleoplasm; regulation of transcription from RNA polymerase II promoter;
TP53BP1	5	positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; RNA polymerase II transcription cofactor activity; nucleus; nucleoplasm;
HMGA1	5	positive regulation of transcription, DNA-dependent; nuclear hormone receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nucleus; nucleoplasm;
NSD1	5	positive regulation of transcription, DNA-dependent; thyroid hormone receptor binding; nuclear hormone receptor binding; transcription cofactor activity; nucleus;
RAN	5	positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; transcription coactivator activity; gene expression; nucleoplasm;
NCOR1	5	thyroid hormone receptor binding; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;
TAF10	5	transcription coactivator activity; gene expression; nucleus; nucleoplasm; transcription initiation from RNA polymerase II promoter;

Genes shared at least 2 KEGG pathways with MED14 (count: 0)

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Region: chrX:40507558..40595110 View in gBrowse