ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0000226
Name microtubule cytoskeleton organization
Type biological process
No. of Genes in ADHDgene  16
Source Pathway by PBA (with statistical significance of FDR<0.05)

PBA Result (with statistical significance of FDR<0.05)
Data Set Reference Gene Set Mapping Rule P-value FDR Result Link
Lesch KP, 2008 MsigDB 3.0 c5.bp 500kb upstream and downstream of gene < 0.001 0.032333333 Link

Comments for this pathway (count: 1)
PMID Citation Comment
21438138 Ehlis A-C, Bauernschmitt K, et al.Influence of a Genetic Variant of the Neuronal Growth Associated Protein Stathmin 1 on Cognitive and Affective Control Processes: An Event-Related Potential Study. American Journal of Medical Genetics 2011, 156B(3):291-302. Stathmin 1 (STMN1) is a neuronal growth associated protein (...... Stathmin 1 (STMN1) is a neuronal growth associated protein (NGAP) that is involved in microtubule dynamics and plays an important role in neurite outgrowth and synaptic plasticity.An influence of STMN1 should be considered in studies aiming at the etiopathogenesis of a broad range of neuropsychiatric disorders with dysfunctional networking, including neurodegenerative disorders as well as schizophrenia, autism spectrum disorders, anxiety disorders, depression, and ADHD More...

GO related genes in ADHDgene (count: 16)

Literature-origin genes (count: 1)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
DISC1 disrupted in schizophrenia 1 1q42.1 1(1/0/0) IMP[18955030]

Genes from other sources Help (count: 15)

Approved Symbol Approved Name Source Evidence[PMID]
MARK4 MAP/microtubule affinity-regulating kinase 4 Mapped by PBA pathway IMP[14594945]
PPP4C protein phosphatase 4, catalytic subunit Mapped by CNV NAS
CCDC88B coiled-coil domain containing 88B Mapped by significant region IEA
MAPT microtubule-associated protein tau Mapped by LD-proxy; Mapped by PBA pathway IDA[1057175]
TUBG1 tubulin, gamma 1 Mapped by PBA pathway TAS[1904010]
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) Mapped by PBA pathway ISS[10729324]
MAP7 microtubule-associated protein 7 Mapped by significant region; Mapped by PBA pathway TAS[8408219]
SS18 synovial sarcoma translocation, chromosome 18 Mapped by significant region IEA
CDK5RAP2 CDK5 regulatory subunit associated protein 2 Mapped by significant region IDA[17959831]
CCDC88A coiled-coil domain containing 88A Mapped by PBA pathway IEA
UXT ubiquitously-expressed, prefoldin-like chaperone Mapped by PBA pathway IMP[16221885]
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase Mapped by PBA pathway TAS[11237715]
TEKT5 tektin 5 Mapped by significant region IEA
MID1 midline 1 (Opitz/BBB syndrome) Mapped by PBA pathway TAS[10077590]
CLASP1 cytoplasmic linker associated protein 1 Mapped by PBA pathway IGI[15631994]