ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TTK
Symbol Alias	MPS1L1, CT96
Approved Name	TTK protein kinase
Name Alias	cancer/testis antigen 96
Location	6q13-q21
Position	chr6:80713604-80752244, +
External Links	HGNC: 12401 Entrez Gene: 7272 Ensembl: ENSG00000112742 UCSC: uc003pjc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0004713	protein tyrosine kinase activity	Molecular Function		10
GO:0004712	protein serine/threonine/tyrosine kinase activity	Molecular Function		2
GO:0004674	protein serine/threonine kinase activity	Molecular Function		61
GO:0042802	identical protein binding	Molecular Function		70
GO:0005819	spindle	Cellular Component	TAS[10366450]	29
GO:0007051	spindle organization	Biological Process	TAS[10366450]	5
GO:0005515	protein binding	Molecular Function	IPI[19273613]	910
GO:0005524	ATP binding	Molecular Function		228
GO:0008284	positive regulation of cell proliferation	Biological Process	TAS[1639825]	69
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation	Biological Process	TAS[19018011]	3
GO:0007052	mitotic spindle organization	Biological Process	TAS[7737118]	7
GO:0007094	mitotic cell cycle spindle assembly checkpoint	Biological Process	TAS[10366450]	6

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...

Genes shared at least 5 GO terms with TTK (count: 5)

Gene Symbol	Pathway Count	Pathway List
MAP3K11	5	protein tyrosine kinase activity; protein serine/threonine kinase activity; identical protein binding; protein binding; ATP binding;
ATM	5	protein serine/threonine kinase activity; spindle; protein binding; ATP binding; mitotic cell cycle spindle assembly checkpoint;
MAPK1	5	protein serine/threonine kinase activity; spindle; protein binding; ATP binding; positive regulation of cell proliferation;
TGFBR1	5	protein serine/threonine kinase activity; protein binding; ATP binding; positive regulation of cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation;
KIF11	5	microtubule cytoskeleton organization; spindle; spindle organization; ATP binding; mitotic spindle organization;

Genes shared at least 2 KEGG pathways with TTK (count: 0)

View in gBrowse

Region: chr6:80713604..80752244 View in gBrowse