ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TPPP
Symbol Alias	p25alpha, TPPP1, p25, TPPP/p25
Approved Name	tubulin polymerization promoting protein
Name Alias	brain specific protein p25 alpha
Location	5p15.33
Position	chr5:659977-693510, -
External Links	HGNC: 24164 Entrez Gene: 11076 Ensembl: ENSG00000171368 UCSC: uc003jbh.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048471	perinuclear region of cytoplasm	Cellular Component	IDA[15590652]	87
GO:0001578	microtubule bundle formation	Biological Process	IDA[17105200]	8
GO:0005515	protein binding	Molecular Function	IPI[15590652]	910
GO:0005634	nucleus	Cellular Component	IDA[18028908]	770
GO:0005737	cytoplasm	Cellular Component	IDA[18028908]	690
GO:0015631	tubulin binding	Molecular Function	IDA[17105200]	9
GO:0031334	positive regulation of protein complex assembly	Biological Process		4
GO:0032273	positive regulation of protein polymerization	Biological Process	IDA[15590652]	1
GO:0046785	microtubule polymerization	Biological Process	IDA[18028908]	2
GO:0005874	microtubule	Cellular Component	IDA[18028908]	52
GO:0005886	plasma membrane	Cellular Component		772
GO:0005925	focal adhesion	Cellular Component		26
GO:0008017	microtubule binding	Molecular Function		32

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TPPP (count: 23)

Gene Symbol	Pathway Count	Pathway List
CDK5RAP2	8	perinuclear region of cytoplasm; microtubule bundle formation; protein binding; cytoplasm; microtubule cytoskeleton organization; tubulin binding; microtubule; microtubule binding;
MAP1S	8	perinuclear region of cytoplasm; microtubule bundle formation; protein binding; nucleus; microtubule cytoskeleton organization; tubulin binding; microtubule; microtubule binding;
GSK3B	6	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; positive regulation of protein complex assembly; plasma membrane;
LPXN	6	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane; focal adhesion;
PAFAH1B1	6	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; microtubule cytoskeleton organization; microtubule binding;
SNCA	6	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane; microtubule binding;
APC	6	protein binding; nucleus; cytoplasm; microtubule cytoskeleton organization; plasma membrane; microtubule binding;
PRC1	6	protein binding; nucleus; cytoplasm; microtubule cytoskeleton organization; plasma membrane; microtubule binding;
EHD3	5	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane;
MAGI2	5	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane;
MALT1	5	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane;
NF2	5	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane;
PDE2A	5	perinuclear region of cytoplasm; protein binding; nucleus; cytoplasm; plasma membrane;
CENPJ	5	protein binding; microtubule cytoskeleton organization; tubulin binding; microtubule polymerization; microtubule;
CEP57	5	protein binding; nucleus; cytoplasm; microtubule; microtubule binding;
CLASP2	5	protein binding; cytoplasm; microtubule cytoskeleton organization; microtubule; plasma membrane;
CRYAB	5	protein binding; nucleus; cytoplasm; plasma membrane; microtubule binding;
HOOK3	5	protein binding; cytoplasm; microtubule cytoskeleton organization; microtubule; microtubule binding;
KIF23	5	protein binding; nucleus; microtubule cytoskeleton organization; microtubule; microtubule binding;
MAPT	5	protein binding; microtubule cytoskeleton organization; microtubule; plasma membrane; microtubule binding;
PPP4C	5	protein binding; nucleus; cytoplasm; microtubule cytoskeleton organization; plasma membrane;
UXT	5	protein binding; nucleus; cytoplasm; microtubule cytoskeleton organization; microtubule binding;
KATNB1	5	cytoplasm; microtubule cytoskeleton organization; microtubule; plasma membrane; microtubule binding;

Genes shared at least 2 KEGG pathways with TPPP (count: 0)

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Region: chr5:659977..693510 View in gBrowse