ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TUBGCP2
Symbol Alias	GCP2, Spc97p, SPBC97
Approved Name	tubulin, gamma complex associated protein 2
Location	10q26.3
Position	chr10:135093135-135125841, -
External Links	HGNC: 18599 Entrez Gene: 10844 Ensembl: ENSG00000130640 UCSC: uc001lmg.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV; Mapped by LD-proxy; Mapped by PBA pathway; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 24)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs12244716	Chr10:135128382(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)

LD-proxies (count: 23)

rs_ID	Location	Functional Annotation
rs7085530	Chr10:135129177(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs3008336	Chr10:135099533(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2275725	Chr10:135089035(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs2995318	Chr10:135091159(Fwd)	downstream_gene_variant; upstream_gene_variant
rs3008328	Chr10:135092590(Fwd)	downstream_gene_variant; upstream_gene_variant
rs11101684	Chr10:135111870(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3008348	Chr10:135112259(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3008352	Chr10:135117127(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3008337	Chr10:135099553(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2995335	Chr10:135121432(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3008338	Chr10:135099999(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs11101690	Chr10:135121732(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs3008339	Chr10:135100346(Fwd)	NMD_transcript_variant; intron_variant
rs12250582	Chr10:135128391(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2275724	Chr10:135088741(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2995324	Chr10:135095408(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2298120	Chr10:135112940(Fwd)	NMD_transcript_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant
rs3008333	Chr10:135098345(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs2995332	Chr10:135113819(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant
rs3008334	Chr10:135098672(Fwd)	NMD_transcript_variant; synonymous_variant; upstream_gene_variant
rs3008349	Chr10:135114559(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs3008335	Chr10:135098830(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs3008354	Chr10:135120646(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_23	chr10:132453545-135284293 (NCBI36 / hg18)	2830749	10q26.3	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000226	microtubule cytoskeleton organization	Biological Process		39

GO terms by database search (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000086	G2/M transition of mitotic cell cycle	Biological Process		29
GO:0000922	spindle pole	Cellular Component		22
GO:0005515	protein binding	Molecular Function	IPI[16980960]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005813	centrosome	Cellular Component		71
GO:0005815	microtubule organizing center	Cellular Component	TAS[9566967]	19
GO:0005829	cytosol	Cellular Component		447
GO:0005881	cytoplasmic microtubule	Cellular Component	TAS[9566967]	8
GO:0006461	protein complex assembly	Biological Process	TAS[9566967]	28
GO:0007020	microtubule nucleation	Biological Process	TAS[9566967]	8

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TUBGCP2 (count: 35)

Gene Symbol	Pathway Count	Pathway List
CLASP1	8	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol; cytoplasmic microtubule; microtubule nucleation;
PAFAH1B1	8	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; protein binding; nucleus; nucleolus; centrosome; cytosol;
CDK5RAP2	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; spindle pole; protein binding; centrosome; cytosol;
CENPJ	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol; microtubule nucleation;
CEP164	7	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; nucleus; nucleolus; centrosome; cytosol;
CEP57	7	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; nucleus; nucleolus; centrosome; cytosol;
CKAP5	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; spindle pole; protein binding; centrosome; cytosol;
CLASP2	7	mitotic cell cycle; microtubule cytoskeleton organization; protein binding; microtubule organizing center; cytosol; cytoplasmic microtubule; microtubule nucleation;
MAPRE1	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol; cytoplasmic microtubule;
NUMA1	7	mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle pole; protein binding; nucleus; nucleolus; cytosol;
PLK1	7	mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle pole; protein binding; nucleus; centrosome; cytosol;
TUBGCP4	7	mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle pole; centrosome; cytosol; protein complex assembly; microtubule nucleation;
TUBGCP5	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; spindle pole; centrosome; cytosol; microtubule nucleation;
TUBGCP6	7	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; spindle pole; centrosome; cytosol; microtubule nucleation;
APC	7	microtubule cytoskeleton organization; protein binding; nucleus; centrosome; cytosol; cytoplasmic microtubule; protein complex assembly;
CEP250	6	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; centrosome; microtubule organizing center; cytosol;
KIF23	6	mitotic cell cycle; microtubule cytoskeleton organization; protein binding; nucleus; centrosome; cytosol;
KIF2C	6	mitotic cell cycle; microtubule cytoskeleton organization; protein binding; nucleus; cytosol; cytoplasmic microtubule;
NDE1	6	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol; microtubule nucleation;
TUBG1	6	mitotic cell cycle; microtubule cytoskeleton organization; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol;
ZW10	6	mitotic cell cycle; spindle pole; protein binding; nucleus; cytosol; protein complex assembly;
CDC25B	5	mitotic cell cycle; G2/M transition of mitotic cell cycle; spindle pole; centrosome; cytosol;
CEP76	5	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol;
CNTRL	5	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol;
CSNK1E	5	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; nucleus; cytosol;
DCTN3	5	mitotic cell cycle; G2/M transition of mitotic cell cycle; protein binding; centrosome; cytosol;
SMC1A	5	mitotic cell cycle; microtubule cytoskeleton organization; protein binding; nucleus; nucleolus;
SMC3	5	mitotic cell cycle; microtubule cytoskeleton organization; spindle pole; protein binding; nucleus;
PRC1	5	microtubule cytoskeleton organization; spindle pole; protein binding; nucleus; nucleolus;
CHEK1	5	G2/M transition of mitotic cell cycle; protein binding; nucleus; centrosome; cytosol;
LATS1	5	G2/M transition of mitotic cell cycle; spindle pole; protein binding; microtubule organizing center; cytosol;
LATS2	5	spindle pole; protein binding; nucleus; microtubule organizing center; cytosol;
GSK3B	5	protein binding; nucleus; nucleolus; centrosome; cytosol;
MAPK1	5	protein binding; nucleus; nucleolus; microtubule organizing center; cytosol;
RFWD2	5	protein binding; nucleus; nucleolus; centrosome; cytosol;

Genes shared at least 2 KEGG pathways with TUBGCP2 (count: 0)

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Region: chr10:135093135..135125841 View in gBrowse