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- Data Summary
Gene Report
Approved Symbol | RFWD2 |
---|---|
Symbol Alias | FLJ10416, COP1, RNF200 |
Approved Name | ring finger and WD repeat domain 2 |
Location | 1q25.1-q25.2 |
Position | chr1:175913967-176176629, - |
External Links |
HGNC: 17440 Entrez Gene: 64326 Ensembl: ENSG00000143207 UCSC: uc001gku.1 |
No. of Studies | 0 (significant: 0; non-significant: 0; trend: 0) |
Source | Mapped by significant region |
Region Name | Position | No. of Studies (significant/non-significant/trend) |
---|---|---|
1q25.1 | chr1:172900000-176000000 | 1 (1/0/0) |
GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)
GO terms by database search (count: 14)
ID | Name | Type | Evidence[PMID] | No. of Genes in ADHDgene |
---|---|---|---|---|
GO:0000075 | cell cycle checkpoint | Biological Process | 21 | |
GO:0005634 | nucleus | Cellular Component | 770 | |
GO:0005515 | protein binding | Molecular Function | 910 | |
GO:0005730 | nucleolus | Cellular Component | 243 | |
GO:0005654 | nucleoplasm | Cellular Component | 183 | |
GO:0005813 | centrosome | Cellular Component | 71 | |
GO:0005737 | cytoplasm | Cellular Component | 690 | |
GO:0005925 | focal adhesion | Cellular Component | 26 | |
GO:0005829 | cytosol | Cellular Component | 447 | |
GO:0008270 | zinc ion binding | Molecular Function | 323 | |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | Biological Process | 11 | |
GO:0016874 | ligase activity | Molecular Function | 12 | |
GO:0016607 | nuclear speck | Cellular Component | 34 | |
GO:0016567 | protein ubiquitination | Biological Process | 41 |
ID | Name | No. of Genes in ADHDgene | Brief Description |
---|---|---|---|
hsa04115 | p53 signaling pathway | 14 | p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More... |
hsa04120 | Ubiquitin mediated proteolysis | 29 | Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More... |
Gene Symbol | Pathway Count | Pathway List |
---|---|---|
RCHY1 | 2 | p53 signaling pathway; Ubiquitin mediated proteolysis; |
Region: chr1:175913967..176176629 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Last update: Feb 26, 2014