ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RFWD2
Symbol Alias	FLJ10416, COP1, RNF200
Approved Name	ring finger and WD repeat domain 2
Location	1q25.1-q25.2
Position	chr1:175913967-176176629, -
External Links	HGNC: 17440 Entrez Gene: 64326 Ensembl: ENSG00000143207 UCSC: uc001gku.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.1	chr1:172900000-176000000	1 (1/0/0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	No. of Genes in ADHDgene
GO:0000075	cell cycle checkpoint	Biological Process	21
GO:0005634	nucleus	Cellular Component	770
GO:0005515	protein binding	Molecular Function	910
GO:0005730	nucleolus	Cellular Component	243
GO:0005654	nucleoplasm	Cellular Component	183
GO:0005813	centrosome	Cellular Component	71
GO:0005737	cytoplasm	Cellular Component	690
GO:0005925	focal adhesion	Cellular Component	26
GO:0005829	cytosol	Cellular Component	447
GO:0008270	zinc ion binding	Molecular Function	323
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process	11
GO:0016874	ligase activity	Molecular Function	12
GO:0016607	nuclear speck	Cellular Component	34
GO:0016567	protein ubiquitination	Biological Process	41

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04115	p53 signaling pathway	14	p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More...
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with RFWD2 (count: 99)

Gene Symbol	Pathway Count	Pathway List
PSMC3	7	cell cycle checkpoint; nucleus; protein binding; nucleoplasm; cytoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
MAPK1	7	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; focal adhesion; cytosol;
RBM4	7	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; zinc ion binding; nuclear speck;
RCHY1	7	nucleus; protein binding; nucleolus; cytoplasm; zinc ion binding; nuclear speck; protein ubiquitination;
CDC45	6	cell cycle checkpoint; nucleus; protein binding; nucleoplasm; centrosome; cytoplasm;
CHEK1	6	cell cycle checkpoint; nucleus; protein binding; nucleoplasm; centrosome; cytosol;
RAD9A	6	cell cycle checkpoint; nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
SMC1A	6	cell cycle checkpoint; nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
AATF	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; focal adhesion;
CBL	6	nucleus; protein binding; cytoplasm; cytosol; zinc ion binding; protein ubiquitination;
CEP164	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; cytosol;
CEP57	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; cytosol;
DHX9	6	nucleus; protein binding; nucleolus; nucleoplasm; centrosome; cytoplasm;
EFTUD2	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; nuclear speck;
FLII	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; focal adhesion;
FUS	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; zinc ion binding;
GSK3B	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; cytosol;
MALT1	6	nucleus; protein binding; nucleolus; cytoplasm; cytosol; protein ubiquitination;
MAPK3	6	nucleus; protein binding; nucleolus; nucleoplasm; focal adhesion; cytosol;
MEN1	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; cytosol;
NEDD4L	6	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol; protein ubiquitination;
NUMA1	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; cytosol;
PAFAH1B1	6	nucleus; protein binding; nucleolus; centrosome; cytoplasm; cytosol;
PGR	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; zinc ion binding;
PLK1	6	nucleus; protein binding; nucleoplasm; centrosome; cytosol; protein ubiquitination;
SART1	6	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm; cytosol;
SF3A3	6	nucleus; protein binding; nucleolus; nucleoplasm; zinc ion binding; nuclear speck;
TNFAIP3	6	nucleus; protein binding; centrosome; cytoplasm; cytosol; zinc ion binding;
TRIM22	6	nucleus; cytoplasm; zinc ion binding; ligase activity; nuclear speck; protein ubiquitination;
U2AF1	6	nucleus; protein binding; nucleolus; nucleoplasm; zinc ion binding; nuclear speck;
DDB1	5	cell cycle checkpoint; nucleus; protein binding; nucleoplasm; cytoplasm;
MRE11A	5	cell cycle checkpoint; nucleus; protein binding; nucleolus; nucleoplasm;
PSMB7	5	cell cycle checkpoint; protein binding; nucleoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
PSMD5	5	cell cycle checkpoint; protein binding; nucleoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
PSMD7	5	cell cycle checkpoint; protein binding; nucleoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
PSME1	5	cell cycle checkpoint; nucleoplasm; cytoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
RAD1	5	cell cycle checkpoint; nucleus; protein binding; nucleolus; nucleoplasm;
UBB	5	cell cycle checkpoint; protein binding; nucleoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
UBC	5	cell cycle checkpoint; protein binding; nucleoplasm; cytosol; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest;
AIP	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
ALKBH8	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
APC	5	nucleus; protein binding; centrosome; cytoplasm; cytosol;
ARRB1	5	nucleus; protein binding; cytoplasm; cytosol; protein ubiquitination;
ARRB2	5	nucleus; protein binding; cytoplasm; cytosol; protein ubiquitination;
ATXN1	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
BAIAP2	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
BARD1	5	nucleus; protein binding; cytoplasm; zinc ion binding; protein ubiquitination;
BSPRY	5	nucleus; nucleolus; cytoplasm; focal adhesion; zinc ion binding;
CCS	5	nucleus; protein binding; cytoplasm; cytosol; zinc ion binding;
CD2BP2	5	nucleus; protein binding; nucleoplasm; cytoplasm; nuclear speck;
CRBN	5	nucleus; protein binding; nucleolus; cytoplasm; protein ubiquitination;
DAXX	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
DCPS	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
DGCR8	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
DPF2	5	nucleus; nucleolus; centrosome; cytoplasm; zinc ion binding;
EGLN3	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
FANCC	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
HERC2	5	nucleus; protein binding; cytoplasm; zinc ion binding; protein ubiquitination;
HINFP	5	nucleus; protein binding; nucleolus; nucleoplasm; zinc ion binding;
HNRNPA2B1	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
HNRNPH1	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
IARS	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
ID2	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
IRF7	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
IRF9	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
KIF23	5	nucleus; protein binding; nucleoplasm; centrosome; cytosol;
KLHL20	5	nucleus; protein binding; nucleolus; cytoplasm; protein ubiquitination;
LPXN	5	nucleus; protein binding; cytoplasm; focal adhesion; zinc ion binding;
MAML1	5	nucleus; protein binding; nucleolus; nucleoplasm; nuclear speck;
NR4A2	5	nucleus; protein binding; nucleoplasm; cytoplasm; zinc ion binding;
PARK2	5	nucleus; protein binding; cytoplasm; cytosol; zinc ion binding;
PDCD4	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
PPP1CA	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
PRKCB	5	nucleus; protein binding; cytoplasm; cytosol; zinc ion binding;
PRPF4	5	nucleus; protein binding; nucleolus; nucleoplasm; nuclear speck;
PSPC1	5	nucleus; protein binding; nucleolus; cytoplasm; nuclear speck;
RAD23B	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
RBPJ	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
RCC1	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
RELA	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
RNF169	5	nucleus; nucleoplasm; zinc ion binding; ligase activity; protein ubiquitination;
RNF40	5	nucleus; protein binding; nucleolus; cytoplasm; zinc ion binding;
SLU7	5	nucleus; nucleolus; cytoplasm; zinc ion binding; nuclear speck;
SNCA	5	nucleus; protein binding; cytoplasm; cytosol; zinc ion binding;
SSRP1	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
STXBP3	5	nucleus; protein binding; nucleolus; cytoplasm; cytosol;
SYVN1	5	nucleus; protein binding; nucleolus; zinc ion binding; protein ubiquitination;
TFAP2A	5	nucleus; protein binding; nucleolus; centrosome; cytoplasm;
TRIM32	5	nucleus; protein binding; cytoplasm; zinc ion binding; protein ubiquitination;
TRIM5	5	nucleus; protein binding; nucleolus; cytoplasm; zinc ion binding;
TRIP12	5	nucleus; protein binding; nucleoplasm; cytoplasm; protein ubiquitination;
TUBGCP2	5	nucleus; protein binding; nucleolus; centrosome; cytosol;
WWP1	5	nucleus; protein binding; cytoplasm; cytosol; protein ubiquitination;
XRCC5	5	nucleus; protein binding; nucleolus; nucleoplasm; cytoplasm;
YAP1	5	nucleus; protein binding; nucleoplasm; cytoplasm; cytosol;
ZBTB16	5	nucleus; protein binding; zinc ion binding; nuclear speck; protein ubiquitination;
ZFR	5	nucleus; protein binding; nucleolus; cytoplasm; zinc ion binding;
XPO1	5	protein binding; nucleolus; nucleoplasm; cytoplasm; cytosol;
RNF19A	5	centrosome; cytoplasm; zinc ion binding; ligase activity; protein ubiquitination;

Genes shared at least 2 KEGG pathways with RFWD2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
RCHY1	2	p53 signaling pathway; Ubiquitin mediated proteolysis;

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Region: chr1:175913967..176176629 View in gBrowse