ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIP12
Symbol Alias	KIAA0045
Approved Name	thyroid hormone receptor interactor 12
Location	2q36.3
Position	chr2:230628554-230787955, -1
External Links	HGNC: 12306 Entrez Gene: 9320 Ensembl: ENSG00000153827 UCSC: uc002vpw.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0009790	embryo development	biological process	ISS	19
GO:0005575	cellular_component	cellular component	ND	118
GO:0046966	thyroid hormone receptor binding	molecular function	IDA[7776974]	17
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	biological process	IMP	2
GO:0005634	nucleus	cellular component	IBA	877
GO:0006974	response to DNA damage stimulus	biological process	IMP	41
GO:0016567	protein ubiquitination	biological process	NAS	48
GO:2000780	negative regulation of double-strand break repair	biological process	IMP	3
GO:0005737	cytoplasm	cellular component	IBA	781
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IBA; IDA[18627766]; IMP[19028681]	15
GO:0005515	protein binding	molecular function	IPI[18627766]	1015
GO:0005654	nucleoplasm	cellular component	IDA	210
GO:0004842	ubiquitin-protein ligase activity	molecular function	IBA; IDA[18627766]; IMP[19028681]; NAS	60
GO:0006281	DNA repair	biological process	IEA	70

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34

Genes shared at least 5 GO terms with TRIP12 (count: 42)

Gene Symbol	Pathway Count	Pathway List
HERC2	8	nucleus; response to DNA damage stimulus; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; DNA repair;
BARD1	7	nucleus; response to DNA damage stimulus; protein ubiquitination; cytoplasm; protein binding; ubiquitin-protein ligase activity; DNA repair;
NEDD4L	7	nucleus; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; nucleoplasm; ubiquitin-protein ligase activity;
NCOA6	6	thyroid hormone receptor binding; nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
OTUB1	6	negative regulation of histone H2A K63-linked ubiquitination; response to DNA damage stimulus; negative regulation of double-strand break repair; cytoplasm; protein binding; DNA repair;
RAD9A	6	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm; DNA repair;
TRIM32	6	nucleus; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
MEN1	6	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm; DNA repair;
TP53BP1	6	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm; DNA repair;
ERCC8	6	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; ubiquitin-protein ligase activity; DNA repair;
DDB1	6	nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; nucleoplasm; DNA repair;
RCHY1	6	nucleus; protein ubiquitination; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
E4F1	5	embryo development; protein ubiquitination; cytoplasm; protein binding; nucleoplasm;
MMS19	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; DNA repair;
RNF169	5	nucleus; response to DNA damage stimulus; protein ubiquitination; negative regulation of double-strand break repair; nucleoplasm;
MALT1	5	nucleus; protein ubiquitination; cytoplasm; protein binding; ubiquitin-protein ligase activity;
USP28	5	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
XRCC5	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
H2AFX	5	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
MRE11A	5	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
RFWD3	5	nucleus; protein ubiquitination; cytoplasm; ubiquitin-protein ligase activity; DNA repair;
HERC5	5	nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
CHD1L	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; DNA repair;
UBE3A	5	nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
CBL	5	nucleus; protein ubiquitination; cytoplasm; protein binding; ubiquitin-protein ligase activity;
RAD23B	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
FANCA	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
IRF7	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm;
PARK2	5	nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
YAP1	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm;
MAPK1	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm;
KLHL20	5	nucleus; protein ubiquitination; cytoplasm; protein binding; ubiquitin-protein ligase activity;
EGLN3	5	nucleus; response to DNA damage stimulus; cytoplasm; protein binding; nucleoplasm;
PRPF19	5	nucleus; cytoplasm; protein binding; ubiquitin-protein ligase activity; DNA repair;
SMC1A	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
RAD1	5	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
HECTD1	5	nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity;
SMC3	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
CHEK1	5	nucleus; response to DNA damage stimulus; protein binding; nucleoplasm; DNA repair;
FANCC	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
SSRP1	5	nucleus; cytoplasm; protein binding; nucleoplasm; DNA repair;
FANCL	5	response to DNA damage stimulus; cytoplasm; nucleoplasm; ubiquitin-protein ligase activity; DNA repair;

Genes shared at least 2 KEGG pathways with TRIP12 (count: 0)

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Region: chr2:230628554..230787955 View in gBrowse