ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TRIP12
Symbol Alias	KIAA0045
Approved Name	thyroid hormone receptor interactor 12
Location	2q36.3
Position	chr2:230631930-230787955, -
External Links	HGNC: 12306 Entrez Gene: 9320 Ensembl: ENSG00000153827 UCSC: uc002vpw.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:1901315	negative regulation of histone H2A K63-linked ubiquitination	Biological Process		2
GO:2000780	negative regulation of double-strand break repair	Biological Process		3
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process	IDA[18627766]; IMP[19028681]	16
GO:0046966	thyroid hormone receptor binding	Molecular Function	IDA[7776974]	18
GO:0005575	cellular_component	Cellular Component		98
GO:0005515	protein binding	Molecular Function	IPI[18627766]	910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[18627766]; IMP[19028681]	52
GO:0016567	protein ubiquitination	Biological Process		41
GO:0009790	embryo development	Biological Process		17
GO:0006974	response to DNA damage stimulus	Biological Process		37
GO:0006281	DNA repair	Biological Process		62
GO:0005737	cytoplasm	Cellular Component		690
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...

Genes shared at least 5 GO terms with TRIP12 (count: 47)

Gene Symbol	Pathway Count	Pathway List
HERC2	8	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; response to DNA damage stimulus; DNA repair; cytoplasm; nucleus;
NEDD4L	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleoplasm; nucleus;
NCOA6	7	thyroid hormone receptor binding; protein binding; nuclear hormone receptor binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
BARD1	7	protein binding; ubiquitin-protein ligase activity; protein ubiquitination; response to DNA damage stimulus; DNA repair; cytoplasm; nucleus;
OTUB1	6	negative regulation of histone H2A K63-linked ubiquitination; negative regulation of double-strand break repair; protein binding; response to DNA damage stimulus; DNA repair; cytoplasm;
DDB1	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
RCHY1	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
TRIM32	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
WWP1	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
ERCC8	6	protein binding; ubiquitin-protein ligase activity; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
MEN1	6	protein binding; response to DNA damage stimulus; DNA repair; cytoplasm; nucleoplasm; nucleus;
MMS19	6	protein binding; nuclear hormone receptor binding; response to DNA damage stimulus; DNA repair; cytoplasm; nucleus;
RAD9A	6	protein binding; response to DNA damage stimulus; DNA repair; cytoplasm; nucleoplasm; nucleus;
TP53BP1	6	protein binding; response to DNA damage stimulus; DNA repair; cytoplasm; nucleoplasm; nucleus;
RNF169	5	negative regulation of double-strand break repair; protein ubiquitination; response to DNA damage stimulus; nucleoplasm; nucleus;
HECTD1	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; cytoplasm; nucleus;
HERC5	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; cytoplasm; nucleus;
PARK2	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; cytoplasm; nucleus;
UBE3A	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; ubiquitin-protein ligase activity; cytoplasm; nucleus;
MED1	5	thyroid hormone receptor binding; protein binding; nuclear hormone receptor binding; nucleoplasm; nucleus;
MED30	5	thyroid hormone receptor binding; protein binding; nuclear hormone receptor binding; nucleoplasm; nucleus;
MED4	5	thyroid hormone receptor binding; protein binding; nuclear hormone receptor binding; nucleoplasm; nucleus;
NCOR1	5	thyroid hormone receptor binding; protein binding; cytoplasm; nucleoplasm; nucleus;
CBL	5	protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
CHD1L	5	protein binding; response to DNA damage stimulus; DNA repair; cytoplasm; nucleus;
CHEK1	5	protein binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
EGLN3	5	protein binding; response to DNA damage stimulus; cytoplasm; nucleoplasm; nucleus;
FANCA	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
FANCC	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
H2AFX	5	protein binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
IRF7	5	protein binding; response to DNA damage stimulus; cytoplasm; nucleoplasm; nucleus;
KLHL20	5	protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
MALT1	5	protein binding; ubiquitin-protein ligase activity; protein ubiquitination; cytoplasm; nucleus;
MAPK1	5	protein binding; response to DNA damage stimulus; cytoplasm; nucleoplasm; nucleus;
MRE11A	5	protein binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
PRPF19	5	protein binding; ubiquitin-protein ligase activity; DNA repair; cytoplasm; nucleus;
RAD1	5	protein binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
RAD23B	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
RFWD2	5	protein binding; protein ubiquitination; cytoplasm; nucleoplasm; nucleus;
SMARCD3	5	protein binding; nuclear hormone receptor binding; cytoplasm; nucleoplasm; nucleus;
SMC1A	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
SMC3	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
SSRP1	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
USP28	5	protein binding; response to DNA damage stimulus; DNA repair; nucleoplasm; nucleus;
XRCC5	5	protein binding; DNA repair; cytoplasm; nucleoplasm; nucleus;
YAP1	5	protein binding; response to DNA damage stimulus; cytoplasm; nucleoplasm; nucleus;
RFWD3	5	ubiquitin-protein ligase activity; protein ubiquitination; DNA repair; cytoplasm; nucleus;

Genes shared at least 2 KEGG pathways with TRIP12 (count: 0)

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Region: chr2:230631930..230787955 View in gBrowse