ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HERC5
Symbol Alias	CEB1
Approved Name	hect domain and RLD 5
Location	4q22.1-q23
Position	chr4:89378268-89427314, +
External Links	HGNC: 24368 Entrez Gene: 51191 Ensembl: ENSG00000138646 UCSC: uc003hrt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_32	chr4:89231344-90528335 (NCBI Build 36.1 (hg18))	763128	4q22.1	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Biological Process		16
GO:0045087	innate immune response	Biological Process		54
GO:0032480	negative regulation of type I interferon production	Biological Process		10
GO:0042296	ISG15 ligase activity	Molecular Function		2
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0032020	ISG15-protein conjugation	Biological Process		2
GO:0005737	cytoplasm	Cellular Component		690
GO:0005829	cytosol	Cellular Component		447
GO:0051607	defense response to virus	Biological Process		15
GO:0048471	perinuclear region of cytoplasm	Cellular Component		87
GO:0050688	regulation of defense response to virus	Biological Process		2
GO:0004842	ubiquitin-protein ligase activity	Molecular Function		52
GO:0000079	regulation of cyclin-dependent protein kinase activity	Biological Process	TAS[10581175]	4
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function		910

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with HERC5 (count: 31)

Gene Symbol	Pathway Count	Pathway List
UBE2L6	8	innate immune response; negative regulation of type I interferon production; ISG15 ligase activity; cytokine-mediated signaling pathway; ISG15-protein conjugation; cytosol; ubiquitin-protein ligase activity; protein binding;
PARK2	7	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; cytosol; perinuclear region of cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
MALT1	7	innate immune response; cytoplasm; cytosol; perinuclear region of cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
RELA	7	innate immune response; cytokine-mediated signaling pathway; cytoplasm; cytosol; defense response to virus; nucleus; protein binding;
TNFAIP3	7	innate immune response; negative regulation of type I interferon production; cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
NEDD4L	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
TRIM32	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; innate immune response; cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
UBE3A	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
WWP1	6	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
IRF7	6	innate immune response; cytokine-mediated signaling pathway; cytoplasm; cytosol; nucleus; protein binding;
PYCARD	6	innate immune response; cytoplasm; cytosol; defense response to virus; nucleus; protein binding;
TRIM5	6	innate immune response; cytoplasm; defense response to virus; ubiquitin-protein ligase activity; nucleus; protein binding;
IRF9	6	cytokine-mediated signaling pathway; cytoplasm; cytosol; defense response to virus; nucleus; protein binding;
HECTD1	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
HERC2	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
HERC6	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus;
RCHY1	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
RNF146	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
TRIP12	5	protein ubiquitination involved in ubiquitin-dependent protein catabolic process; cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
MAPK1	5	innate immune response; cytoplasm; cytosol; nucleus; protein binding;
MAPK3	5	innate immune response; cytokine-mediated signaling pathway; cytosol; nucleus; protein binding;
PRKD1	5	innate immune response; cytoplasm; cytosol; nucleus; protein binding;
UBB	5	innate immune response; negative regulation of type I interferon production; cytokine-mediated signaling pathway; cytosol; protein binding;
UBC	5	innate immune response; negative regulation of type I interferon production; cytokine-mediated signaling pathway; cytosol; protein binding;
CBL	5	cytoplasm; cytosol; ubiquitin-protein ligase activity; nucleus; protein binding;
GSK3B	5	cytoplasm; cytosol; perinuclear region of cytoplasm; nucleus; protein binding;
KLHL20	5	cytoplasm; perinuclear region of cytoplasm; ubiquitin-protein ligase activity; nucleus; protein binding;
PAFAH1B1	5	cytoplasm; cytosol; perinuclear region of cytoplasm; nucleus; protein binding;
PDE2A	5	cytoplasm; cytosol; perinuclear region of cytoplasm; nucleus; protein binding;
PSMC3	5	cytoplasm; cytosol; perinuclear region of cytoplasm; nucleus; protein binding;
SNCA	5	cytoplasm; cytosol; perinuclear region of cytoplasm; nucleus; protein binding;

Genes shared at least 2 KEGG pathways with HERC5 (count: 0)

View in gBrowse

Region: chr4:89378268..89427314 View in gBrowse