ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RCHY1
Previous Symbol	ZNF363
Symbol Alias	CHIMP, DKFZp586C1620, PRO1996, RNF199, ARNIP, PIRH2, ZCHY
Approved Name	ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
Previous Name	"zinc finger protein 363", "ring finger and CHY zinc finger domain containing 1"
Name Alias	"androgen-receptor N-terminal-interacting protein", "p53-induced protein with a RING-H2 domain", "zinc finger, CHY-type"
Location	4q21.1-q21.3
Position	chr4:76404247-76439974, -1
External Links	HGNC: 17479 Entrez Gene: 25898 Ensembl: ENSG00000163743 UCSC: uc003hik.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_43	chr4:75931128-77058132 (NCBI Build 36.1 (hg18))	1076977	4q13.3-4q21.1	Gain	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	biological process	IDA[19483087]	8
GO:0005730	nucleolus	cellular component	IDA	271
GO:0000151	ubiquitin ligase complex	cellular component	IDA[19043414]	17
GO:0005102	receptor binding	molecular function	IEA	64
GO:0004842	ubiquitin-protein ligase activity	molecular function	IDA[19483087]	60
GO:0005634	nucleus	cellular component	IDA	877
GO:0002039	p53 binding	molecular function	IPI[19043414]	15
GO:0005737	cytoplasm	cellular component	IDA	781
GO:0042803	protein homodimerization activity	molecular function	IPI[19483087]	128
GO:0031398	positive regulation of protein ubiquitination	biological process	IDA[19483087]	11
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IDA[19483087]	15
GO:0008270	zinc ion binding	molecular function	IDA[19043414]	367
GO:0051865	protein autoubiquitination	biological process	IDA[19483087]	7
GO:0016607	nuclear speck	cellular component	IEA	40
GO:0005515	protein binding	molecular function	IPI	1015
GO:0016567	protein ubiquitination	biological process	IDA[19043414]	48

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	34
hsa04115	p53 signaling pathway	14

Genes shared at least 5 GO terms with RCHY1 (count: 55)

Gene Symbol	Pathway Count	Pathway List
STUB1	8	positive regulation of proteasomal ubiquitin-dependent protein catabolic process; ubiquitin ligase complex; ubiquitin-protein ligase activity; cytoplasm; protein homodimerization activity; positive regulation of protein ubiquitination; protein autoubiquitination; protein binding;
RNF40	8	nucleolus; ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; cytoplasm; protein homodimerization activity; zinc ion binding; protein binding;
BARD1	8	ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; cytoplasm; protein homodimerization activity; zinc ion binding; protein binding; protein ubiquitination;
AXIN1	7	positive regulation of proteasomal ubiquitin-dependent protein catabolic process; nucleus; p53 binding; cytoplasm; protein homodimerization activity; positive regulation of protein ubiquitination; protein binding;
MALT1	7	nucleolus; ubiquitin-protein ligase activity; nucleus; cytoplasm; positive regulation of protein ubiquitination; protein binding; protein ubiquitination;
RNF20	7	nucleolus; ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; p53 binding; zinc ion binding; protein binding;
TRIM5	7	nucleolus; ubiquitin-protein ligase activity; nucleus; cytoplasm; protein homodimerization activity; zinc ion binding; protein binding;
FBXO4	7	ubiquitin ligase complex; ubiquitin-protein ligase activity; cytoplasm; protein homodimerization activity; positive regulation of protein ubiquitination; protein binding; protein ubiquitination;
PARK2	7	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding; protein autoubiquitination; protein binding;
HERC2	7	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding; protein binding; protein ubiquitination;
TRIM32	7	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding; protein binding; protein ubiquitination;
PGR	6	nucleolus; receptor binding; nucleus; cytoplasm; zinc ion binding; protein binding;
RNF2	6	nucleolus; ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; zinc ion binding; protein binding;
RBM4	6	nucleolus; nucleus; cytoplasm; zinc ion binding; nuclear speck; protein binding;
KLHL20	6	nucleolus; ubiquitin-protein ligase activity; nucleus; cytoplasm; protein binding; protein ubiquitination;
DAXX	6	nucleolus; nucleus; p53 binding; cytoplasm; protein homodimerization activity; protein binding;
PRPF19	6	ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; cytoplasm; nuclear speck; protein binding;
RNF144B	6	ubiquitin ligase complex; ubiquitin-protein ligase activity; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding; protein binding;
ARRB2	6	receptor binding; nucleus; cytoplasm; positive regulation of protein ubiquitination; protein binding; protein ubiquitination;
RFWD3	6	ubiquitin-protein ligase activity; nucleus; p53 binding; cytoplasm; zinc ion binding; protein ubiquitination;
RNF146	6	ubiquitin-protein ligase activity; nucleus; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; zinc ion binding; protein autoubiquitination; protein binding;
TRIP12	6	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; protein ubiquitination;
NEDD4L	6	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding; protein ubiquitination;
CBL	6	ubiquitin-protein ligase activity; nucleus; cytoplasm; zinc ion binding; protein binding; protein ubiquitination;
ZBTB16	6	nucleus; protein homodimerization activity; zinc ion binding; nuclear speck; protein binding; protein ubiquitination;
ZNF174	5	nucleolus; nucleus; cytoplasm; protein homodimerization activity; zinc ion binding;
CRBN	5	nucleolus; nucleus; cytoplasm; protein binding; protein ubiquitination;
FUS	5	nucleolus; nucleus; cytoplasm; zinc ion binding; protein binding;
PAFAH1B1	5	nucleolus; nucleus; cytoplasm; protein homodimerization activity; protein binding;
CEP57	5	nucleolus; nucleus; cytoplasm; protein homodimerization activity; protein binding;
GSK3B	5	nucleolus; nucleus; p53 binding; cytoplasm; protein binding;
U2AF1	5	nucleolus; nucleus; zinc ion binding; nuclear speck; protein binding;
FOXP1	5	nucleolus; nucleus; cytoplasm; protein homodimerization activity; zinc ion binding;
EFTUD2	5	nucleolus; nucleus; cytoplasm; nuclear speck; protein binding;
KLHL7	5	nucleolus; nucleus; cytoplasm; protein homodimerization activity; protein ubiquitination;
SLU7	5	nucleolus; nucleus; cytoplasm; zinc ion binding; nuclear speck;
ZFR	5	nucleolus; nucleus; cytoplasm; zinc ion binding; protein binding;
SYVN1	5	nucleolus; nucleus; zinc ion binding; protein binding; protein ubiquitination;
GATAD2A	5	nucleolus; nucleus; zinc ion binding; nuclear speck; protein binding;
PSPC1	5	nucleolus; nucleus; cytoplasm; nuclear speck; protein binding;
SF3A3	5	nucleolus; nucleus; zinc ion binding; nuclear speck; protein binding;
BRAP	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein binding;
TRAF7	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; zinc ion binding; protein binding; protein ubiquitination;
FBXO25	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; protein binding; protein ubiquitination;
FBXO7	5	ubiquitin ligase complex; ubiquitin-protein ligase activity; nucleus; cytoplasm; protein binding;
HECTD1	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding;
TRIM13	5	ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein autoubiquitination; protein binding;
LRSAM1	5	ubiquitin-protein ligase activity; cytoplasm; zinc ion binding; protein autoubiquitination; protein binding;
BIRC3	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; zinc ion binding; protein binding;
MGRN1	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; zinc ion binding; protein binding;
HERC5	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding;
TNFAIP3	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; zinc ion binding; protein binding;
UBE3A	5	ubiquitin-protein ligase activity; nucleus; cytoplasm; protein ubiquitination involved in ubiquitin-dependent protein catabolic process; protein binding;
TRIM22	5	nucleus; cytoplasm; zinc ion binding; nuclear speck; protein ubiquitination;
CREBBP	5	nucleus; p53 binding; cytoplasm; zinc ion binding; protein binding;

Genes shared at least 2 KEGG pathways with RCHY1 (count: 0)

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Region: chr4:76404247..76439974 View in gBrowse