ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RNF2
Symbol Alias	BAP-1, BAP1, DING, HIPI3, RING1B, RING2
Approved Name	ring finger protein 2
Location	1q25.3
Position	chr1:185014496-185071740, +
External Links	HGNC: 10061 Entrez Gene: 6045 Ensembl: ENSG00000121481 UCSC: uc001grc.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0071535	RING-like zinc finger domain binding	Molecular Function	IPI[16714294]	1
GO:0000151	ubiquitin ligase complex	Cellular Component	IDA[16714294]	15
GO:0003682	chromatin binding	Molecular Function		48
GO:0001739	sex chromatin	Cellular Component		2
GO:0001702	gastrulation with mouth forming second	Biological Process		5
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0005730	nucleolus	Cellular Component		243
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function		910
GO:0004842	ubiquitin-protein ligase activity	Molecular Function	IDA[16714294]	52
GO:0016604	nuclear body	Cellular Component		4
GO:0009948	anterior/posterior axis specification	Biological Process		3
GO:0008270	zinc ion binding	Molecular Function	IDA[16714294]	323
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0071339	MLL1 complex	Cellular Component	IDA[15960975]	7
GO:0035518	histone H2A monoubiquitination	Biological Process	IDA[16943429]	1
GO:0035102	PRC1 complex	Cellular Component	IDA[19636380]	1
GO:0031519	PcG protein complex	Cellular Component	IDA[16943429]	2

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with RNF2 (count: 27)

Gene Symbol	Pathway Count	Pathway List
NCOR2	7	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleolus; nucleus; protein binding; nuclear body; transcription, DNA-dependent;
RNF20	7	ubiquitin ligase complex; chromatin binding; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
MEN1	6	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleolus; nucleus; protein binding; transcription, DNA-dependent;
MTA2	6	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleolus; nucleus; protein binding; zinc ion binding;
NSD1	6	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; gastrulation with mouth forming second; nucleus; zinc ion binding; transcription, DNA-dependent;
RCHY1	6	ubiquitin ligase complex; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
RNF40	6	ubiquitin ligase complex; nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
HINFP	6	chromatin binding; nucleolus; nucleus; protein binding; zinc ion binding; transcription, DNA-dependent;
GATA6	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding; zinc ion binding;
KAT5	5	negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; transcription, DNA-dependent;
KDM1A	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding; transcription, DNA-dependent;
MED1	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleolus; nucleus; protein binding;
NCOR1	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding; transcription, DNA-dependent;
NEDD4L	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; ubiquitin-protein ligase activity; transcription, DNA-dependent;
SREBF1	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleus; protein binding; transcription, DNA-dependent;
TCF25	5	negative regulation of transcription from RNA polymerase II promoter; nucleolus; nucleus; protein binding; transcription, DNA-dependent;
TFAP2A	5	negative regulation of transcription from RNA polymerase II promoter; chromatin binding; nucleolus; nucleus; protein binding;
BARD1	5	ubiquitin ligase complex; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
CBFA2T3	5	chromatin binding; nucleolus; protein binding; zinc ion binding; transcription, DNA-dependent;
EED	5	chromatin binding; sex chromatin; nucleus; protein binding; transcription, DNA-dependent;
PRKCB	5	chromatin binding; nucleus; protein binding; zinc ion binding; transcription, DNA-dependent;
SMC1A	5	chromatin binding; mitotic cell cycle; nucleolus; nucleus; protein binding;
PHF2	5	nucleolus; nucleus; protein binding; zinc ion binding; transcription, DNA-dependent;
TRIM5	5	nucleolus; nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding;
BIRC2	5	nucleus; protein binding; ubiquitin-protein ligase activity; zinc ion binding; transcription, DNA-dependent;
PCGF3	5	nucleus; protein binding; zinc ion binding; transcription, DNA-dependent; PcG protein complex;
ZBTB16	5	nucleus; protein binding; nuclear body; zinc ion binding; transcription, DNA-dependent;

Genes shared at least 2 KEGG pathways with RNF2 (count: 0)

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Region: chr1:185014496..185071740 View in gBrowse