ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCOR2
Symbol Alias	SMRT, SMRTE, TRAC-1, CTG26, TNRC14
Approved Name	nuclear receptor corepressor 2
Previous Name	"nuclear receptor co-repressor 2"
Location	12q24
Position	chr12:124808961-125052135, -1
External Links	HGNC: 7673 Entrez Gene: 9612 Ensembl: ENSG00000196498 UCSC: uc010tbb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_26	chr12:122465458-124605386 (NCBI36 / hg18)	2139929	12q24.31-12q24.32	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044255	cellular lipid metabolic process	biological process	TAS	33
GO:0005634	nucleus	cellular component	IC[18052923]; IDA	877
GO:0047485	protein N-terminus binding	molecular function	IPI[16893456]	27
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	TAS	44
GO:0006351	transcription, DNA-dependent	biological process	TAS	281
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	biological process	IMP[19955185]	1
GO:0007179	transforming growth factor beta receptor signaling pathway	biological process	TAS	13
GO:0005112	Notch binding	molecular function	IPI[10713164]	2
GO:0042826	histone deacetylase binding	molecular function	IPI[11804585]	11
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0005730	nucleolus	cellular component	IDA	271
GO:0003714	transcription corepressor activity	molecular function	IDA[18052923]; IMP[12628926]	33
GO:0003682	chromatin binding	molecular function	IEA	50
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[10097068]; IMP[19955185]; TAS	90
GO:0005515	protein binding	molecular function	IPI	1015
GO:0017053	transcriptional repressor complex	cellular component	IDA[11804585]	8
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0007219	Notch signaling pathway	biological process	TAS	23
GO:0010467	gene expression	biological process	TAS	154
GO:0016604	nuclear body	cellular component	IDA[16030140]	5
GO:0003677	DNA binding	molecular function	IEA	257

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04330	Notch signaling pathway	9

Genes shared at least 5 GO terms with NCOR2 (count: 95)

Gene Symbol	Pathway Count	Pathway List
CREBBP	11	cellular lipid metabolic process; nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; small molecule metabolic process; Notch signaling pathway; gene expression; nuclear body;
MEN1	11	nucleus; protein N-terminus binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; nucleoplasm; nucleolus; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; gene expression;
MED1	10	cellular lipid metabolic process; nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; small molecule metabolic process; gene expression;
SNW1	10	nucleus; transcription initiation from RNA polymerase II promoter; Notch binding; nucleoplasm; nucleolus; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; protein binding; Notch signaling pathway; gene expression;
RBPJ	9	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; negative regulation of transcription from RNA polymerase II promoter; protein binding; Notch signaling pathway; gene expression; DNA binding;
NCOA6	8	cellular lipid metabolic process; nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; chromatin binding; protein binding; small molecule metabolic process;
NEDD4L	8	nucleus; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; gene expression;
UBC	8	transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; Notch signaling pathway; gene expression;
UBB	8	transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transforming growth factor beta receptor signaling pathway; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; Notch signaling pathway; gene expression;
PGR	7	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; protein binding; gene expression; DNA binding;
MAML1	7	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; protein binding; Notch signaling pathway; gene expression;
HINFP	7	nucleus; transcription, DNA-dependent; nucleoplasm; nucleolus; chromatin binding; protein binding; DNA binding;
YAP1	7	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; transcription corepressor activity; chromatin binding; protein binding; gene expression;
TAF13	7	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; protein binding; gene expression; DNA binding;
NR5A1	7	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; chromatin binding; protein binding; gene expression; DNA binding;
RNF2	7	nucleus; transcription, DNA-dependent; nucleolus; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; nuclear body;
SSRP1	7	nucleus; nucleoplasm; nucleolus; chromatin binding; protein binding; gene expression; DNA binding;
SMARCD3	6	cellular lipid metabolic process; nucleus; transcription, DNA-dependent; nucleoplasm; protein binding; small molecule metabolic process;
GRHL1	6	cellular lipid metabolic process; nucleus; transcription, DNA-dependent; nucleoplasm; small molecule metabolic process; DNA binding;
LPIN1	6	cellular lipid metabolic process; nucleus; transcription, DNA-dependent; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; small molecule metabolic process;
RELA	6	nucleus; protein N-terminus binding; nucleoplasm; chromatin binding; protein binding; DNA binding;
NRIP1	6	nucleus; transcription, DNA-dependent; histone deacetylase binding; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; protein binding;
SREBF1	6	nucleus; transcription, DNA-dependent; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
XRCC5	6	nucleus; transcription, DNA-dependent; nucleoplasm; nucleolus; protein binding; DNA binding;
TLE4	6	nucleus; nucleoplasm; transcription corepressor activity; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway;
DHX9	6	nucleus; nucleoplasm; nucleolus; protein binding; gene expression; DNA binding;
MED4	6	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; protein binding; gene expression;
PSMC3	6	nucleus; nucleoplasm; transcription corepressor activity; protein binding; small molecule metabolic process; gene expression;
KDM1A	6	nucleus; transcription, DNA-dependent; nucleoplasm; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding;
TAF4B	6	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; gene expression; DNA binding;
TCF25	6	nucleus; transcription, DNA-dependent; nucleolus; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
ZBTB16	6	nucleus; transcription, DNA-dependent; protein binding; transcriptional repressor complex; nuclear body; DNA binding;
MAPK1	6	nucleus; transcription, DNA-dependent; nucleoplasm; nucleolus; protein binding; DNA binding;
SMC1A	6	nucleus; nucleoplasm; nucleolus; chromatin binding; protein binding; gene expression;
NR4A2	6	nucleus; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; nucleoplasm; protein binding; gene expression;
ATXN1	6	nucleus; transcription, DNA-dependent; nucleoplasm; nucleolus; protein binding; DNA binding;
HEY2	6	nucleus; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; transcriptional repressor complex; Notch signaling pathway;
NIPBL	6	nucleus; protein N-terminus binding; histone deacetylase binding; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding;
ESRRA	6	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression; DNA binding;
HES1	6	nucleus; histone deacetylase binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; Notch signaling pathway; DNA binding;
FUS	6	nucleus; nucleoplasm; nucleolus; protein binding; gene expression; DNA binding;
E4F1	6	transcription, DNA-dependent; nucleoplasm; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
XPO1	6	transforming growth factor beta receptor signaling pathway; nucleoplasm; nucleolus; negative regulation of transcription from RNA polymerase II promoter; protein binding; gene expression;
DDX23	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
TLE1	5	nucleus; nucleoplasm; chromatin binding; protein binding; Notch signaling pathway;
RAD9A	5	nucleus; histone deacetylase binding; nucleoplasm; nucleolus; protein binding;
FEN1	5	nucleus; nucleoplasm; nucleolus; protein binding; DNA binding;
EFTUD2	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
GATA6	5	nucleus; nucleoplasm; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding;
ZNF205	5	nucleus; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
RCC1	5	nucleus; nucleoplasm; nucleolus; chromatin binding; protein binding;
SF3A1	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
RNPS1	5	nucleus; transcription, DNA-dependent; nucleoplasm; protein binding; gene expression;
TAF10	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression;
HMGA1	5	nucleus; transcription, DNA-dependent; nucleoplasm; protein binding; DNA binding;
ZNF423	5	nucleus; transcription, DNA-dependent; protein binding; Notch signaling pathway; DNA binding;
MRE11A	5	nucleus; nucleoplasm; nucleolus; protein binding; DNA binding;
EEF1D	5	nucleus; transcription, DNA-dependent; protein binding; gene expression; DNA binding;
MED15	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression;
PRPF4	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
HSPA8	5	nucleus; transcription, DNA-dependent; nucleolus; protein binding; gene expression;
MED12	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; chromatin binding; gene expression;
NCBP1	5	nucleus; nucleoplasm; protein binding; gene expression; DNA binding;
IRF7	5	nucleus; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
MED30	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; protein binding; gene expression;
ELK3	5	nucleus; transcription, DNA-dependent; nucleolus; transcription corepressor activity; protein binding;
MAML2	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; Notch signaling pathway; gene expression;
DAXX	5	nucleus; protein N-terminus binding; transcription, DNA-dependent; nucleolus; protein binding;
HNRNPA2B1	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
TFAP2B	5	nucleus; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
NPAT	5	nucleus; protein N-terminus binding; transcription, DNA-dependent; transcription corepressor activity; protein binding;
DRAP1	5	nucleus; transcription, DNA-dependent; transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; DNA binding;
MED27	5	nucleus; transcription initiation from RNA polymerase II promoter; nucleoplasm; nucleolus; gene expression;
BCLAF1	5	nucleus; transcription, DNA-dependent; nucleolus; protein binding; DNA binding;
MTA2	5	nucleus; nucleolus; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding;
SMARCB1	5	nucleus; transcription, DNA-dependent; nucleoplasm; nucleolus; protein binding;
DGCR8	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
SAP18	5	nucleus; transcription, DNA-dependent; nucleolus; transcription corepressor activity; protein binding;
KAT5	5	nucleus; transcription, DNA-dependent; nucleolus; negative regulation of transcription from RNA polymerase II promoter; protein binding;
MAPK3	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
HNRNPH1	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
HIRA	5	nucleus; transcription, DNA-dependent; transcription corepressor activity; chromatin binding; protein binding;
U2AF1	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
SNRNP200	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
SF3A3	5	nucleus; nucleoplasm; nucleolus; protein binding; gene expression;
NSD1	5	nucleus; transcription, DNA-dependent; transcription corepressor activity; chromatin binding; negative regulation of transcription from RNA polymerase II promoter;
HNF1B	5	nucleus; nucleolus; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
PPP1CA	5	nucleus; transforming growth factor beta receptor signaling pathway; nucleolus; protein binding; small molecule metabolic process;
TFAP4	5	nucleus; histone deacetylase binding; protein binding; transcriptional repressor complex; DNA binding;
MED20	5	transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; nucleoplasm; protein binding; gene expression;
NR6A1	5	transcription initiation from RNA polymerase II promoter; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; DNA binding;
TXN	5	transcription, DNA-dependent; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; small molecule metabolic process;
MYB	5	transcription, DNA-dependent; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
CIITA	5	transcription, DNA-dependent; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; protein binding; DNA binding;
CBFA2T3	5	transcription, DNA-dependent; nucleoplasm; nucleolus; chromatin binding; protein binding;

Genes shared at least 2 KEGG pathways with NCOR2 (count: 0)

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Region: chr12:124808961..125052135 View in gBrowse