ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NCOR2
Symbol Alias	SMRT, SMRTE, TRAC-1, CTG26, TNRC14
Approved Name	nuclear receptor corepressor 2
Previous Name	nuclear receptor co-repressor 2
Location	12q24
Position	chr12:124808961-125052010, -
External Links	HGNC: 7673 Entrez Gene: 9612 Ensembl: ENSG00000196498 UCSC: uc010tay.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_26	chr12:122465458-124605386 (NCBI36 / hg18)	2139929	12q24.31-12q24.32	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 21)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 21)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003714	transcription corepressor activity	Molecular Function	IDA[18052923]; IMP[12628926]	29
GO:0003682	chromatin binding	Molecular Function		48
GO:0003677	DNA binding	Molecular Function		220
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[10097068]; IMP[19955185]	78
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	IC[18052923]	770
GO:0005515	protein binding	Molecular Function		910
GO:0005112	Notch binding	Molecular Function	IPI[10713164]	2
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process		14
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005730	nucleolus	Cellular Component		243
GO:0017053	transcriptional repressor complex	Cellular Component	IDA[11804585]	8
GO:0016604	nuclear body	Cellular Component	IDA[16030140]	4
GO:0010467	gene expression	Biological Process		140
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0047485	protein N-terminus binding	Molecular Function	IPI[16893456]	23
GO:0042826	histone deacetylase binding	Molecular Function	IPI[11804585]	10
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0072365	regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter	Biological Process	IMP[19955185]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04330	Notch signaling pathway	8	The Notch signaling pathway is an evolutionarily conserved, ...... The Notch signaling pathway is an evolutionarily conserved, intercellular signaling mechanism essential for proper embryonic development in all metazoan organisms in the Animal kingdom. The Notch proteins (Notch1-Notch4 in vertebrates) are single-pass receptors that are activated by the Delta (or Delta-like) and Jagged/Serrate families of membrane-bound ligands. They are transported to the plasma membrane as cleaved, but otherwise intact polypeptides. Interaction with ligand leads to two additional proteolytic cleavages that liberate the Notch intracellular domain (NICD) from the plasma membrane. The NICD translocates to the nucleus, where it forms a complex with the DNA binding protein CSL, displacing a histone deacetylase (HDAc)-co-repressor (CoR) complex from CSL. Components of an activation complex, such as MAML1 and histone acetyltransferases (HATs), are recruited to the NICD-CSL complex, leading to the transcriptional activation of Notch target genes. More...

Genes shared at least 5 GO terms with NCOR2 (count: 88)

Gene Symbol	Pathway Count	Pathway List
NCOR1	15	transcription corepressor activity; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; transcriptional repressor complex; gene expression; Notch signaling pathway; small molecule metabolic process; histone deacetylase binding; cellular lipid metabolic process;
MEN1	11	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; nucleolus; gene expression; protein N-terminus binding;
SNW1	10	transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; Notch binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression; Notch signaling pathway;
MED1	10	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression; small molecule metabolic process; cellular lipid metabolic process;
RBPJ	9	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression; Notch signaling pathway;
NCOA6	8	chromatin binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; small molecule metabolic process; cellular lipid metabolic process;
NEDD4L	8	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; gene expression;
UBB	8	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; gene expression; Notch signaling pathway;
UBC	8	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; gene expression; Notch signaling pathway;
YAP1	7	transcription corepressor activity; chromatin binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
HINFP	7	chromatin binding; DNA binding; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
NR5A1	7	chromatin binding; DNA binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
RNF2	7	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription, DNA-dependent; nucleolus; nuclear body;
SSRP1	7	chromatin binding; DNA binding; nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
E2F5	7	DNA binding; nucleoplasm; protein binding; transforming growth factor beta receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; gene expression;
PGR	7	DNA binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression;
TAF13	7	DNA binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression;
MAML1	7	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression; Notch signaling pathway;
NRIP1	6	transcription corepressor activity; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription, DNA-dependent; histone deacetylase binding;
PSMC3	6	transcription corepressor activity; nucleoplasm; nucleus; protein binding; gene expression; small molecule metabolic process;
KDM1A	6	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent;
NIPBL	6	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; protein N-terminus binding; histone deacetylase binding;
RELA	6	chromatin binding; DNA binding; nucleoplasm; nucleus; protein binding; protein N-terminus binding;
SMC1A	6	chromatin binding; nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
SREBF1	6	chromatin binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription, DNA-dependent;
ATXN1	6	DNA binding; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
DHX9	6	DNA binding; nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
ESRRA	6	DNA binding; nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
FUS	6	DNA binding; nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
GRHL1	6	DNA binding; nucleoplasm; nucleus; transcription, DNA-dependent; small molecule metabolic process; cellular lipid metabolic process;
HES1	6	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; Notch signaling pathway; histone deacetylase binding;
MAPK1	6	DNA binding; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
TAF4B	6	DNA binding; nucleoplasm; nucleus; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression;
TCF25	6	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
XRCC5	6	DNA binding; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
ZBTB16	6	DNA binding; nucleus; protein binding; transcription, DNA-dependent; transcriptional repressor complex; nuclear body;
HEY2	6	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcriptional repressor complex; Notch signaling pathway; histone deacetylase binding;
LPIN1	6	negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent; small molecule metabolic process; histone deacetylase binding; cellular lipid metabolic process;
XPO1	6	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transforming growth factor beta receptor signaling pathway; nucleolus; gene expression;
MED4	6	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; nucleolus; gene expression;
NR4A2	6	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; gene expression;
SMARCD3	6	nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; small molecule metabolic process; cellular lipid metabolic process;
DRAP1	5	transcription corepressor activity; DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent;
ELK3	5	transcription corepressor activity; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
HIRA	5	transcription corepressor activity; chromatin binding; nucleus; protein binding; transcription, DNA-dependent;
NPAT	5	transcription corepressor activity; nucleus; protein binding; transcription, DNA-dependent; protein N-terminus binding;
NSD1	5	transcription corepressor activity; chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; transcription, DNA-dependent;
SAP18	5	transcription corepressor activity; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
CBFA2T3	5	chromatin binding; nucleoplasm; protein binding; transcription, DNA-dependent; nucleolus;
GATA6	5	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding;
MED12	5	chromatin binding; nucleoplasm; nucleus; transcription initiation from RNA polymerase II promoter; gene expression;
MTA2	5	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; nucleolus;
MYB	5	chromatin binding; DNA binding; negative regulation of transcription from RNA polymerase II promoter; protein binding; transcription, DNA-dependent;
RCC1	5	chromatin binding; nucleoplasm; nucleus; protein binding; nucleolus;
TFAP2A	5	chromatin binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; nucleolus;
BCLAF1	5	DNA binding; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
EEF1D	5	DNA binding; nucleus; protein binding; transcription, DNA-dependent; gene expression;
FEN1	5	DNA binding; nucleoplasm; nucleus; protein binding; nucleolus;
HMGA1	5	DNA binding; nucleoplasm; nucleus; protein binding; transcription, DNA-dependent;
HNF1B	5	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; nucleolus;
IRF7	5	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding;
MRE11A	5	DNA binding; nucleoplasm; nucleus; protein binding; nucleolus;
NCBP1	5	DNA binding; nucleoplasm; nucleus; protein binding; gene expression;
NR4A3	5	DNA binding; nucleoplasm; nucleus; transcription initiation from RNA polymerase II promoter; gene expression;
NR6A1	5	DNA binding; negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; transcription initiation from RNA polymerase II promoter; gene expression;
ZNF423	5	DNA binding; nucleus; protein binding; transcription, DNA-dependent; Notch signaling pathway;
KAT5	5	negative regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
TXN	5	negative regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; transcription, DNA-dependent; small molecule metabolic process;
DDX23	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
DGCR8	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
EFTUD2	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
HNRNPA2B1	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
HNRNPH1	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
MAML2	5	nucleoplasm; nucleus; transcription initiation from RNA polymerase II promoter; gene expression; Notch signaling pathway;
MAPK3	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
MED15	5	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
MED30	5	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
PRPF4	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
RAD9A	5	nucleoplasm; nucleus; protein binding; nucleolus; histone deacetylase binding;
SF3A1	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
SF3A3	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
SMARCB1	5	nucleoplasm; nucleus; protein binding; transcription, DNA-dependent; nucleolus;
SNRNP200	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
TAF10	5	nucleoplasm; nucleus; protein binding; transcription initiation from RNA polymerase II promoter; gene expression;
U2AF1	5	nucleoplasm; nucleus; protein binding; nucleolus; gene expression;
DAXX	5	nucleus; protein binding; transcription, DNA-dependent; nucleolus; protein N-terminus binding;
HSPA8	5	nucleus; protein binding; transcription, DNA-dependent; nucleolus; gene expression;
PPP1CA	5	nucleus; protein binding; transforming growth factor beta receptor signaling pathway; nucleolus; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with NCOR2 (count: 0)

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Region: chr12:124808961..125052010 View in gBrowse