ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	EEF1D
Symbol Alias	EF-1D, FLJ20897
Approved Name	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
Location	8q24
Position	chr8:144661892-144681711, -
External Links	HGNC: 3211 Entrez Gene: 1936 Ensembl: ENSG00000104529 UCSC: uc003yyt.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2290416	Chr8:144657600(Fwd)	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant	1(0/0/1)

LD-proxies (count: 1)

rs_ID	Location	Functional Annotation
rs3793371	Chr8:144664299(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003746	translation elongation factor activity	Molecular Function		3
GO:0003677	DNA binding	Molecular Function		220
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0005853	eukaryotic translation elongation factor 1 complex	Cellular Component		2
GO:0006412	translation	Biological Process		42
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005515	protein binding	Molecular Function		910
GO:0004871	signal transducer activity	Molecular Function	IMP[12761501]	49
GO:0005829	cytosol	Cellular Component		447
GO:0005634	nucleus	Cellular Component		770
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IMP[12761501]	27
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0006414	translational elongation	Biological Process		16
GO:0007165	signal transduction	Biological Process	IMP[12761501]	171
GO:0008135	translation factor activity, nucleic acid binding	Molecular Function	TAS[8334168]	3
GO:0010467	gene expression	Biological Process		140

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with EEF1D (count: 53)

Gene Symbol	Pathway Count	Pathway List
EEF1G	8	translation elongation factor activity; eukaryotic translation elongation factor 1 complex; translation; protein binding; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPS3	7	translation; protein binding; cytosol; nucleus; cellular protein metabolic process; translational elongation; gene expression;
HMGA1	6	DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus;
IGHMBP2	6	DNA binding; transcription, DNA-dependent; translation; regulation of transcription, DNA-dependent; protein binding; nucleus;
MAPK1	6	DNA binding; transcription, DNA-dependent; protein binding; cytosol; nucleus; signal transduction;
BIRC2	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
CNOT6	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus; gene expression;
PRKAA1	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus; signal transduction;
PRKCB	6	transcription, DNA-dependent; protein binding; cytosol; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction;
RQCD1	6	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus; gene expression;
RPL13	6	translation; protein binding; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL14	6	translation; protein binding; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPS9	6	translation; protein binding; cytosol; cellular protein metabolic process; translational elongation; gene expression;
HINFP	5	DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus;
NCBP1	5	DNA binding; protein binding; cytosol; nucleus; gene expression;
NCOR2	5	DNA binding; transcription, DNA-dependent; protein binding; nucleus; gene expression;
NDN	5	DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytosol; nucleus;
PGR	5	DNA binding; protein binding; nucleus; signal transduction; gene expression;
RELA	5	DNA binding; protein binding; cytosol; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
SSRP1	5	DNA binding; regulation of transcription, DNA-dependent; protein binding; nucleus; gene expression;
TAF1D	5	DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus;
ZNF646	5	DNA binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus;
APBB1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; signal transduction;
CTNND1	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus;
CTNND2	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; signal transduction;
DAXX	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus;
HABP4	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus;
HSPA8	5	transcription, DNA-dependent; protein binding; cytosol; nucleus; gene expression;
LPXN	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; signal transduction;
MEN1	5	transcription, DNA-dependent; protein binding; cytosol; nucleus; gene expression;
NEDD4L	5	transcription, DNA-dependent; protein binding; cytosol; nucleus; gene expression;
NR4A2	5	transcription, DNA-dependent; protein binding; nucleus; signal transduction; gene expression;
TERF2IP	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
UBB	5	transcription, DNA-dependent; protein binding; cytosol; positive regulation of I-kappaB kinase/NF-kappaB cascade; gene expression;
UBC	5	transcription, DNA-dependent; protein binding; cytosol; positive regulation of I-kappaB kinase/NF-kappaB cascade; gene expression;
WASL	5	transcription, DNA-dependent; regulation of transcription, DNA-dependent; protein binding; cytosol; nucleus;
EIF2B1	5	translation; protein binding; cytosol; cellular protein metabolic process; gene expression;
FAU	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL12	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL35	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL37	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL37A	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPL38	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPS12	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPS15A	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
RPS25	5	translation; cytosol; cellular protein metabolic process; translational elongation; gene expression;
SRP19	5	translation; cytosol; nucleus; cellular protein metabolic process; gene expression;
CBL	5	regulation of transcription, DNA-dependent; protein binding; signal transducer activity; cytosol; nucleus;
CLOCK	5	regulation of transcription, DNA-dependent; signal transducer activity; cytosol; nucleus; signal transduction;
AIP	5	protein binding; signal transducer activity; cytosol; nucleus; signal transduction;
MALT1	5	protein binding; signal transducer activity; cytosol; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade;
NEK6	5	protein binding; signal transducer activity; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction;
PRKD1	5	protein binding; cytosol; nucleus; positive regulation of I-kappaB kinase/NF-kappaB cascade; signal transduction;

Genes shared at least 2 KEGG pathways with EEF1D (count: 0)

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Region: chr8:144661892..144681711 View in gBrowse