ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CNOT6
Symbol Alias	CCR4, KIAA1194
Approved Name	CCR4-NOT transcription complex, subunit 6
Location	5q35.3
Position	chr5:179921412-180005405, +
External Links	HGNC: 14099 Entrez Gene: 57472 Ensembl: ENSG00000113300 UCSC: uc003mlx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0046872	metal ion binding	Molecular Function		170
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity	Biological Process	IDA[18180299]	2
GO:0005515	protein binding	Molecular Function	IPI[18180299]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005829	cytosol	Cellular Component		447
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0010467	gene expression	Biological Process		140
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0004535	poly(A)-specific ribonuclease activity	Molecular Function		1
GO:0003723	RNA binding	Molecular Function		104
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	Biological Process		3
GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	Biological Process		7

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03018	RNA degradation	8	The correct processing, quality control and turnover of cell...... The correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay exist and both pathways are initiated by poly(A) shortening of the mRNA. In the 5' to 3' pathway, this is followed by decapping which then permits the 5' to 3' exonucleolytic degradation of transcripts. In the 3' to 5' pathway, the exosome, a large multisubunit complex, plays a key role. The exosome exists in archaeal cells, too. In bacteria, endoribonuclease E, a key enzyme involved in RNA decay and processing, organizes a protein complex called degradosome. RNase E or R interacts with the phosphate-dependent exoribonuclease polynucleotide phosphorylase, DEAD-box helicases, and additional factors in the RNA-degrading complex. More...

Genes shared at least 5 GO terms with CNOT6 (count: 49)

Gene Symbol	Pathway Count	Pathway List
RQCD1	11	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity; protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent; gene expression; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA poly(A) tail shortening; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
SMG1	7	metal ion binding; protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
DCPS	7	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
DDX6	7	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
HSPA8	7	protein binding; nucleus; cytosol; transcription, DNA-dependent; gene expression; RNA metabolic process; mRNA metabolic process;
LSM4	7	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
NCBP1	7	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
PATL1	7	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
TNKS1BP1	7	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; nuclear-transcribed mRNA poly(A) tail shortening; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay;
PRKAA1	6	metal ion binding; protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
RPL37	6	metal ion binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
EEF1D	6	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent; gene expression;
PSMC3	6	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
RPL13	6	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPL14	6	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPS3	6	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
SMG7	6	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
SNRPD1	6	protein binding; nucleus; cytosol; gene expression; RNA metabolic process; RNA binding;
UBB	6	protein binding; cytosol; transcription, DNA-dependent; gene expression; RNA metabolic process; mRNA metabolic process;
UBC	6	protein binding; cytosol; transcription, DNA-dependent; gene expression; RNA metabolic process; mRNA metabolic process;
XPO1	6	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
ALKBH8	5	metal ion binding; protein binding; nucleus; cytosol; RNA binding;
KAT5	5	metal ion binding; protein binding; nucleus; cytosol; transcription, DNA-dependent;
RPL37A	5	metal ion binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
BIRC2	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
CLNS1A	5	protein binding; nucleus; cytosol; gene expression; RNA metabolic process;
CTNND1	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
DAXX	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
HABP4	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
HMGA1	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
IGHMBP2	5	protein binding; nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA binding;
MEN1	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; gene expression;
NEDD4L	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; gene expression;
PDCD4	5	protein binding; nucleus; cytosol; RNA metabolic process; RNA binding;
PSMB7	5	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
PSMD5	5	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
PSMD7	5	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
PSPC1	5	protein binding; nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA binding;
RPS9	5	protein binding; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
SETD1A	5	protein binding; nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA binding;
SNRPG	5	protein binding; cytosol; gene expression; RNA metabolic process; RNA binding;
WASL	5	protein binding; nucleus; cytosol; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
DDX54	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA metabolic process; RNA binding;
PSMA8	5	nucleus; cytosol; gene expression; RNA metabolic process; mRNA metabolic process;
FAU	5	cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPL12	5	cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPL38	5	cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPS15A	5	cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;
RPS25	5	cytosol; gene expression; RNA metabolic process; mRNA metabolic process; RNA binding;

Genes shared at least 2 KEGG pathways with CNOT6 (count: 0)

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Region: chr5:179921412..180005405 View in gBrowse