ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TERF2IP
Symbol Alias	RAP1
Approved Name	telomeric repeat binding factor 2, interacting protein
Location	16q23.1
Position	chr16:75681635-75691340, +
External Links	HGNC: 19246 Entrez Gene: 54386 Ensembl: ENSG00000166848 UCSC: uc002fet.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 22)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0000781	chromosome, telomeric region	Cellular Component	IDA[12768206]	9
GO:0000723	telomere maintenance	Biological Process	IDA[14565979]	10
GO:0000228	nuclear chromosome	Cellular Component	TAS[10850490]	4
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[19651898]	910
GO:0000784	nuclear chromosome, telomeric region	Cellular Component	IDA[14565979]	2
GO:0000783	nuclear telomere cap complex	Cellular Component	IDA[15181449]	3
GO:0042162	telomeric DNA binding	Molecular Function	TAS[10850490]	4
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		27
GO:0031848	protection from non-homologous end joining at telomere	Biological Process	IMP[17499040]	1
GO:0032205	negative regulation of telomere maintenance	Biological Process	IDA[17055345]; IMP[15100233]	1
GO:0070198	protein localization to chromosome, telomeric region	Biological Process	IMP[17499040]	2
GO:0048239	negative regulation of DNA recombination at telomere	Biological Process		1
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006355	regulation of transcription, DNA-dependent	Biological Process		158
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005737	cytoplasm	Cellular Component		690
GO:0010833	telomere maintenance via telomere lengthening	Biological Process		2
GO:0030870	Mre11 complex	Cellular Component	IDA[15100233]	2
GO:0007004	telomere maintenance via telomerase	Biological Process	TAS[10850490]	3
GO:0010569	regulation of double-strand break repair via homologous recombination	Biological Process		3

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TERF2IP (count: 39)

Gene Symbol	Pathway Count	Pathway List
XRCC5	9	telomere maintenance; nucleus; protein binding; nuclear chromosome, telomeric region; nuclear telomere cap complex; telomeric DNA binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
TINF2	8	chromosome, telomeric region; telomere maintenance; protein binding; nuclear telomere cap complex; telomeric DNA binding; protein localization to chromosome, telomeric region; nucleoplasm; telomere maintenance via telomere lengthening;
MRE11A	6	chromosome, telomeric region; nucleus; protein binding; nucleoplasm; Mre11 complex; telomere maintenance via telomerase;
TP53BP1	6	chromosome, telomeric region; nucleus; protein binding; telomeric DNA binding; nucleoplasm; cytoplasm;
PRKCB	6	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; transcription, DNA-dependent; cytoplasm;
RELA	6	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; nucleoplasm; cytoplasm;
CHEK1	5	chromosome, telomeric region; nucleus; protein binding; nucleoplasm; regulation of double-strand break repair via homologous recombination;
NDNL2	5	chromosome, telomeric region; nucleus; protein binding; regulation of transcription, DNA-dependent; cytoplasm;
SMARCB1	5	nuclear chromosome; nucleus; protein binding; transcription, DNA-dependent; nucleoplasm;
APBB1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
ATXN1	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
BIRC2	5	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
CTNND1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
CTNND2	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
DAXX	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
EEF1D	5	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; transcription, DNA-dependent; regulation of transcription, DNA-dependent;
FLII	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
GRHL1	5	nucleus; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleoplasm; cytoplasm;
HABP4	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
HINFP	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleoplasm;
HMGA1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; nucleoplasm;
IGHMBP2	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
LPXN	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
MALT1	5	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; cytoplasm;
MAPK1	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
MEN1	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
NCOR1	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
NEDD4L	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
NR4A2	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
PRKD1	5	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; cytoplasm;
PSPC1	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
PTPN14	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
RPS6KA4	5	nucleus; protein binding; positive regulation of NF-kappaB transcription factor activity; regulation of transcription, DNA-dependent; cytoplasm;
SCAI	5	nucleus; protein binding; transcription, DNA-dependent; regulation of transcription, DNA-dependent; cytoplasm;
SMARCD3	5	nucleus; protein binding; transcription, DNA-dependent; nucleoplasm; cytoplasm;
SSRP1	5	nucleus; protein binding; regulation of transcription, DNA-dependent; nucleoplasm; cytoplasm;
TRIM5	5	nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; cytoplasm;
UBB	5	protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; transcription, DNA-dependent; nucleoplasm;
UBC	5	protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of NF-kappaB transcription factor activity; transcription, DNA-dependent; nucleoplasm;

Genes shared at least 2 KEGG pathways with TERF2IP (count: 0)

View in gBrowse

Region: chr16:75681635..75691340 View in gBrowse