ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	UBB
Symbol Alias	MGC8385, FLJ25987
Approved Name	ubiquitin B
Name Alias	polyubiquitin B
Location	17p12-p11.2
Position	chr17:16284113-16286054, +
External Links	HGNC: 12463 Entrez Gene: 7314 Ensembl: ENSG00000170315 UCSC: uc002gpx.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 67)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 67)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007219	Notch signaling pathway	Biological Process		21
GO:0007220	Notch receptor processing	Biological Process		2
GO:0007249	I-kappaB kinase/NF-kappaB cascade	Biological Process		5
GO:0007254	JNK cascade	Biological Process		11
GO:0006915	apoptotic process	Biological Process		111
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Biological Process		11
GO:0007173	epidermal growth factor receptor signaling pathway	Biological Process		25
GO:0007179	transforming growth factor beta receptor signaling pathway	Biological Process		14
GO:0005886	plasma membrane	Cellular Component		772
GO:0006281	DNA repair	Biological Process		62
GO:0006351	transcription, DNA-dependent	Biological Process		247
GO:0006367	transcription initiation from RNA polymerase II promoter	Biological Process		42
GO:0002756	MyD88-independent toll-like receptor signaling pathway	Biological Process		9
GO:0005515	protein binding	Molecular Function	IPI[18313049]	910
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005829	cytosol	Cellular Component		447
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0002224	toll-like receptor signaling pathway	Biological Process		10
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Biological Process		14
GO:0000209	protein polyubiquitination	Biological Process		23
GO:0000187	activation of MAPK activity	Biological Process		21
GO:0000278	mitotic cell cycle	Biological Process		63
GO:0000216	M/G1 transition of mitotic cell cycle	Biological Process		13
GO:0000082	G1/S transition of mitotic cell cycle	Biological Process		26
GO:0000080	G1 phase of mitotic cell cycle	Biological Process		6
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process		78
GO:0000084	S phase of mitotic cell cycle	Biological Process		20
GO:0000075	cell cycle checkpoint	Biological Process		21
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway	Biological Process		3
GO:0071456	cellular response to hypoxia	Biological Process		12
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	Biological Process		5
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		10
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	Biological Process		12
GO:0016032	viral reproduction	Biological Process		57
GO:0016044	cellular membrane organization	Biological Process		24
GO:0016070	RNA metabolic process	Biological Process		46
GO:0016071	mRNA metabolic process	Biological Process		34
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0008543	fibroblast growth factor receptor signaling pathway	Biological Process		26
GO:0010008	endosome membrane	Cellular Component		27
GO:0010467	gene expression	Biological Process		140
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	Biological Process		14
GO:0032480	negative regulation of type I interferon production	Biological Process		10
GO:0033554	cellular response to stress	Biological Process		12
GO:0034130	toll-like receptor 1 signaling pathway	Biological Process		10
GO:0016197	endosomal transport	Biological Process		11
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process		13
GO:0030666	endocytic vesicle membrane	Cellular Component		11
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	Biological Process		6
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	Biological Process		8
GO:0042981	regulation of apoptotic process	Biological Process		32
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	Biological Process		14
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process		11
GO:0034134	toll-like receptor 2 signaling pathway	Biological Process		10
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0050852	T cell receptor signaling pathway	Biological Process		21
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0051403	stress-activated MAPK cascade	Biological Process		10
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process		27
GO:0045087	innate immune response	Biological Process		54
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process		27
GO:0046788	egress of virus within host cell	Biological Process		4
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process		131

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05012	Parkinson's disease	22	Parkinson's disease (PD) is a progressive neurodegenerative ...... Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic neurons in the substantia nigra. Mutations in alpha-synuclein, UCHL1 (a ubiquitin carboxy-terminal hydrolase L1), parkin, DJ1 (a parkin-associated protein involved with oxidative stress), and PINK1 (a putative serine threonine kinase) are known to cause early-onset PD. These pathogenic mutations are associated with disease through pathogenic pathways that may commonly lead proteasome dysfunction, mitochondrial impairment, and oxidative stress. Point mutations in alpha-synuclein lead to excessive intracellular accumulation and protofibril formation. Decrease in the amount of soluble alpha-synuclein tends to increase free cytoplasmic dopamine and the formation of reactive oxygen species (ROS). Modification of parkin and UCHL1 are associated with the ubiquitin-proteasome system pathway and may increase proteotoxic stress. Mutations in parkin, DJ1, and PINK1 may alter mitochondiral activity, potentially impairing proteasomal function. Environmental toxins such as N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and rotenone can cause mitochondrial dysfunction and oxidative stress. More...

Genes shared at least 5 GO terms with UBB (count: 152)

Gene Symbol	Pathway Count	Pathway List
UBC	67	Notch signaling pathway; Notch receptor processing; I-kappaB kinase/NF-kappaB cascade; JNK cascade; apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; epidermal growth factor receptor signaling pathway; transforming growth factor beta receptor signaling pathway; plasma membrane; DNA repair; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; activation of MAPK activity; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; S phase of mitotic cell cycle; cell cycle checkpoint; nucleotide-binding oligomerization domain containing signaling pathway; cellular response to hypoxia; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; regulation of transcription from RNA polymerase II promoter in response to hypoxia; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; cellular membrane organization; RNA metabolic process; mRNA metabolic process; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; endosome membrane; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of type I interferon production; cellular response to stress; toll-like receptor 1 signaling pathway; endosomal transport; cytokine-mediated signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; endocytic vesicle membrane; negative regulation of epidermal growth factor receptor signaling pathway; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; egress of virus within host cell; positive regulation of transcription from RNA polymerase II promoter;
PSMB7	23	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein binding; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
PSMC3	23	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein binding; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
PSMD5	23	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein binding; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
PSMD7	23	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein binding; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
MAPK3	22	apoptotic process; epidermal growth factor receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; gene expression; toll-like receptor 1 signaling pathway; cytokine-mediated signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
PSME1	22	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
PSME2	22	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; nucleoplasm; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
MAPK1	21	apoptotic process; epidermal growth factor receptor signaling pathway; transcription, DNA-dependent; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity; Toll signaling pathway; fibroblast growth factor receptor signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; innate immune response;
PSMA8	19	apoptotic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein polyubiquitination; mitotic cell cycle; M/G1 transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of apoptotic process; antigen processing and presentation of exogenous peptide antigen via MHC class I;
RELA	19	MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; cytokine-mediated signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter;
TLR4	17	I-kappaB kinase/NF-kappaB cascade; plasma membrane; protein binding; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity; Toll signaling pathway; endosome membrane; toll-like receptor 1 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter;
MAPK7	17	apoptotic process; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; nerve growth factor receptor signaling pathway; stress-activated MAPK cascade; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
MAPK9	15	JNK cascade; MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; stress-activated MAPK cascade; innate immune response;
MAP2K3	15	MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; activation of MAPK activity; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; stress-activated MAPK cascade; innate immune response;
IRF7	13	MyD88-independent toll-like receptor signaling pathway; protein binding; nucleoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter; Toll signaling pathway; endosome membrane; cytokine-mediated signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter;
TIRAP	12	I-kappaB kinase/NF-kappaB cascade; plasma membrane; protein binding; toll-like receptor signaling pathway; MyD88-dependent toll-like receptor signaling pathway; Toll signaling pathway; toll-like receptor 1 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade;
XPO1	11	transforming growth factor beta receptor signaling pathway; protein binding; nucleoplasm; cytosol; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway;
MEN1	10	transforming growth factor beta receptor signaling pathway; DNA repair; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
E2F5	9	transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; mitotic cell cycle; G1 phase of mitotic cell cycle; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NEDD4L	9	transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter; gene expression; negative regulation of transforming growth factor beta receptor signaling pathway;
CDC26	9	protein binding; nucleoplasm; cytosol; mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
SKP2	9	protein binding; nucleoplasm; cytosol; protein polyubiquitination; mitotic cell cycle; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle; S phase of mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
NCOR1	8	Notch signaling pathway; transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression;
NCOR2	8	Notch signaling pathway; transforming growth factor beta receptor signaling pathway; transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression;
BAD	8	apoptotic process; epidermal growth factor receptor signaling pathway; protein binding; cytosol; cellular response to hypoxia; fibroblast growth factor receptor signaling pathway; cytokine-mediated signaling pathway; nerve growth factor receptor signaling pathway;
PRKD1	8	apoptotic process; plasma membrane; protein binding; cytosol; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter;
PIK3R1	8	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; fibroblast growth factor receptor signaling pathway; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
HSPA8	8	plasma membrane; transcription, DNA-dependent; protein binding; cytosol; cellular membrane organization; RNA metabolic process; mRNA metabolic process; gene expression;
MALT1	8	plasma membrane; protein binding; cytosol; regulation of apoptotic process; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade;
PLK1	8	protein binding; nucleoplasm; cytosol; mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
TCEB1	8	protein binding; nucleoplasm; cytosol; cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; viral reproduction; gene expression; cellular response to stress;
ANAPC4	8	nucleoplasm; cytosol; mitotic cell cycle; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
RBPJ	7	Notch signaling pathway; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
SNW1	7	Notch signaling pathway; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
EGLN3	7	apoptotic process; protein binding; nucleoplasm; cytosol; cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress;
PRKCB	7	apoptotic process; plasma membrane; transcription, DNA-dependent; protein binding; cytosol; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade;
SQSTM1	7	apoptotic process; protein binding; nucleoplasm; cytosol; endosomal transport; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
BCAR1	7	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; regulation of apoptotic process; T cell receptor signaling pathway; nerve growth factor receptor signaling pathway;
GSK3B	7	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
NR4A2	7	transcription, DNA-dependent; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; cellular response to stress; positive regulation of transcription from RNA polymerase II promoter;
RQCD1	7	transcription, DNA-dependent; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression; cytokine-mediated signaling pathway;
TXN	7	transcription, DNA-dependent; protein binding; nucleoplasm; cytosol; negative regulation of transcription from RNA polymerase II promoter; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; innate immune response;
CCND1	7	protein binding; nucleoplasm; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle; G1 phase of mitotic cell cycle; S phase of mitotic cell cycle;
CDC45	7	protein binding; nucleoplasm; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle; cell cycle checkpoint;
CDT1	7	protein binding; nucleoplasm; cytosol; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
NCBP1	7	protein binding; nucleoplasm; cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
ARRB1	6	Notch signaling pathway; plasma membrane; protein binding; cytosol; cellular membrane organization; positive regulation of transcription from RNA polymerase II promoter;
MAML1	6	Notch signaling pathway; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
RIPK3	6	I-kappaB kinase/NF-kappaB cascade; plasma membrane; protein binding; cytosol; positive regulation of NF-kappaB transcription factor activity; innate immune response;
BIRC2	6	apoptotic process; transcription, DNA-dependent; protein binding; cytosol; protein polyubiquitination; positive regulation of I-kappaB kinase/NF-kappaB cascade;
CASP1	6	apoptotic process; protein binding; cytosol; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade;
FADD	6	apoptotic process; protein binding; cytosol; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter;
GATA6	6	apoptotic process; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia; positive regulation of transcription from RNA polymerase II promoter;
PAK1	6	apoptotic process; plasma membrane; protein binding; cytosol; cellular response to stress; T cell receptor signaling pathway;
POLR2G	6	apoptotic process; DNA repair; transcription initiation from RNA polymerase II promoter; nucleoplasm; viral reproduction; gene expression;
TGFBR1	6	apoptotic process; transforming growth factor beta receptor signaling pathway; plasma membrane; protein binding; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of apoptotic process;
ADRBK1	6	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway;
CBL	6	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; fibroblast growth factor receptor signaling pathway; negative regulation of epidermal growth factor receptor signaling pathway;
PRKAR2B	6	epidermal growth factor receptor signaling pathway; plasma membrane; cytosol; mitotic cell cycle; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway;
CAMK2D	6	plasma membrane; nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; cytokine-mediated signaling pathway; endocytic vesicle membrane;
POLE	6	DNA repair; nucleoplasm; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
SMC1A	6	DNA repair; protein binding; nucleoplasm; mitotic cell cycle; cell cycle checkpoint; gene expression;
SMG1	6	DNA repair; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
CNOT6	6	transcription, DNA-dependent; protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
MED1	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; gene expression; positive regulation of transcription from RNA polymerase II promoter;
YAP1	6	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; cytosol; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NCF2	6	protein binding; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response;
RPL13	6	protein binding; cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL14	6	protein binding; cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPS3	6	protein binding; cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPS9	6	protein binding; cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
TNFAIP3	6	protein binding; cytosol; nucleotide-binding oligomerization domain containing signaling pathway; negative regulation of type I interferon production; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; innate immune response;
VEGFA	6	protein binding; negative regulation of transcription from RNA polymerase II promoter; cellular response to hypoxia; regulation of transcription from RNA polymerase II promoter in response to hypoxia; cellular response to stress; positive regulation of transcription from RNA polymerase II promoter;
ADAM17	5	Notch signaling pathway; epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; nerve growth factor receptor signaling pathway;
ARRB2	5	Notch signaling pathway; transforming growth factor beta receptor signaling pathway; plasma membrane; protein binding; cytosol;
MAML2	5	Notch signaling pathway; transcription initiation from RNA polymerase II promoter; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
ARHGEF2	5	apoptotic process; protein binding; cytosol; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity;
GJA1	5	apoptotic process; plasma membrane; protein binding; cellular membrane organization; positive regulation of I-kappaB kinase/NF-kappaB cascade;
MCF2L	5	apoptotic process; plasma membrane; cytosol; nerve growth factor receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
RTN4	5	apoptotic process; plasma membrane; protein binding; regulation of apoptotic process; nerve growth factor receptor signaling pathway;
TAX1BP1	5	apoptotic process; protein binding; cytosol; negative regulation of type I interferon production; innate immune response;
TRAF1	5	apoptotic process; protein binding; regulation of apoptotic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade;
WWOX	5	apoptotic process; plasma membrane; protein binding; cytosol; positive regulation of transcription from RNA polymerase II promoter;
ATM	5	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; DNA repair; protein binding; nucleoplasm; cell cycle checkpoint;
RFWD2	5	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein binding; nucleoplasm; cytosol; cell cycle checkpoint;
ADCY4	5	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway;
ERBB2	5	epidermal growth factor receptor signaling pathway; plasma membrane; transcription, DNA-dependent; protein binding; endosome membrane;
MAPKAP1	5	epidermal growth factor receptor signaling pathway; plasma membrane; cytosol; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway;
PLCE1	5	epidermal growth factor receptor signaling pathway; plasma membrane; protein binding; cytosol; activation of MAPK activity;
RICTOR	5	epidermal growth factor receptor signaling pathway; protein binding; cytosol; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway;
CLNS1A	5	plasma membrane; protein binding; cytosol; RNA metabolic process; gene expression;
CTGF	5	plasma membrane; transcription initiation from RNA polymerase II promoter; cytosol; fibroblast growth factor receptor signaling pathway; gene expression;
CUL5	5	plasma membrane; protein binding; cytosol; G1/S transition of mitotic cell cycle; viral reproduction;
NCK1	5	plasma membrane; protein binding; cytosol; T cell receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter;
STRN3	5	plasma membrane; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
WASL	5	plasma membrane; transcription, DNA-dependent; protein binding; cytosol; endocytic vesicle membrane;
CHEK1	5	DNA repair; protein binding; nucleoplasm; cytosol; cell cycle checkpoint;
FEN1	5	DNA repair; protein binding; nucleoplasm; mitotic cell cycle; S phase of mitotic cell cycle;
GTF2H3	5	DNA repair; transcription initiation from RNA polymerase II promoter; nucleoplasm; viral reproduction; gene expression;
HINFP	5	DNA repair; transcription, DNA-dependent; protein binding; nucleoplasm; G1/S transition of mitotic cell cycle;
NCOA6	5	DNA repair; transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; positive regulation of transcription from RNA polymerase II promoter;
POLD3	5	DNA repair; protein binding; nucleoplasm; mitotic cell cycle; S phase of mitotic cell cycle;
POLD4	5	DNA repair; protein binding; nucleoplasm; mitotic cell cycle; S phase of mitotic cell cycle;
PTTG1	5	DNA repair; protein binding; cytosol; mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;
RBBP8	5	DNA repair; protein binding; G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; cell cycle checkpoint;
SSRP1	5	DNA repair; protein binding; nucleoplasm; viral reproduction; gene expression;
XRCC5	5	DNA repair; transcription, DNA-dependent; protein binding; nucleoplasm; viral reproduction;
EEF1D	5	transcription, DNA-dependent; protein binding; cytosol; gene expression; positive regulation of I-kappaB kinase/NF-kappaB cascade;
HMGA1	5	transcription, DNA-dependent; protein binding; nucleoplasm; cytosol; viral reproduction;
KAT5	5	transcription, DNA-dependent; protein binding; cytosol; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
KDM1A	5	transcription, DNA-dependent; protein binding; nucleoplasm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
MYB	5	transcription, DNA-dependent; protein binding; G1/S transition of mitotic cell cycle; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter;
NUP62	5	transcription, DNA-dependent; protein binding; viral reproduction; cytokine-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade;
PRKAA1	5	transcription, DNA-dependent; protein binding; cytosol; activation of MAPK activity; cellular response to hypoxia;
TERF2IP	5	transcription, DNA-dependent; protein binding; nucleoplasm; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade;
ESRRA	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
NR5A1	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
RORA	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; gene expression; positive regulation of transcription from RNA polymerase II promoter;
TAF10	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; viral reproduction; gene expression;
TAF13	5	transcription initiation from RNA polymerase II promoter; protein binding; nucleoplasm; viral reproduction; gene expression;
CYBA	5	protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response;
DCPS	5	protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
DDX6	5	protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
HERC5	5	protein binding; cytosol; negative regulation of type I interferon production; cytokine-mediated signaling pathway; innate immune response;
LSM4	5	protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
MAVS	5	protein binding; negative regulation of type I interferon production; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription from RNA polymerase II promoter;
PATL1	5	protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
PYCARD	5	protein binding; cytosol; nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; innate immune response;
RAN	5	protein binding; nucleoplasm; cytosol; viral reproduction; gene expression;
RNF31	5	protein binding; protein polyubiquitination; T cell receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; positive regulation of I-kappaB kinase/NF-kappaB cascade;
RRM2	5	protein binding; nucleoplasm; cytosol; mitotic cell cycle; G1/S transition of mitotic cell cycle;
SEC61B	5	protein binding; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I;
SMG7	5	protein binding; cytosol; RNA metabolic process; mRNA metabolic process; gene expression;
SNRPB	5	protein binding; nucleoplasm; cytosol; RNA metabolic process; gene expression;
SNRPD1	5	protein binding; nucleoplasm; cytosol; RNA metabolic process; gene expression;
SNRPD2	5	protein binding; nucleoplasm; cytosol; RNA metabolic process; gene expression;
SNRPD3	5	protein binding; nucleoplasm; cytosol; RNA metabolic process; gene expression;
SNRPG	5	protein binding; nucleoplasm; cytosol; RNA metabolic process; gene expression;
UBE2L6	5	protein binding; cytosol; negative regulation of type I interferon production; cytokine-mediated signaling pathway; innate immune response;
POLA2	5	nucleoplasm; mitotic cell cycle; M/G1 transition of mitotic cell cycle; G1/S transition of mitotic cell cycle; S phase of mitotic cell cycle;
FAU	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL12	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL35	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL37	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL37A	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPL38	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPS12	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPS15A	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
RPS25	5	cytosol; viral reproduction; RNA metabolic process; mRNA metabolic process; gene expression;
VPS37C	5	viral reproduction; cellular membrane organization; endosome membrane; endosomal transport; egress of virus within host cell;
VPS37D	5	viral reproduction; cellular membrane organization; endosome membrane; endosomal transport; egress of virus within host cell;

Genes shared at least 2 KEGG pathways with UBB (count: 0)

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Region: chr17:16284113..16286054 View in gBrowse