ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SEC61B
Approved Name	Sec61 beta subunit
Location	9q22.32-q31.3
Position	chr9:101984346-101992897, 1
External Links	HGNC: 16993 Entrez Gene: 10952 Ensembl: ENSG00000106803 UCSC: uc004azh.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 14)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048408	epidermal growth factor binding	molecular function	IPI[19602593]	1
GO:0030970	retrograde protein transport, ER to cytosol	biological process	IMP[17215517]	1
GO:0010467	gene expression	biological process	TAS	154
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	14
GO:0000060	protein import into nucleus, translocation	biological process	IMP[17215517]	5
GO:0031205	endoplasmic reticulum Sec complex	cellular component	ISS	1
GO:0006412	translation	biological process	TAS	49
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	18
GO:0030433	ER-associated protein catabolic process	biological process	IDA[8945469]	7
GO:0044267	cellular protein metabolic process	biological process	TAS	78
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	biological process	TAS	23
GO:0016021	integral to membrane	cellular component	NAS[8107851]	932
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	14
GO:0005515	protein binding	molecular function	IPI[18555783]	1015

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05110	Vibrio cholerae infection	11

Genes shared at least 5 GO terms with SEC61B (count: 18)

Gene Symbol	Pathway Count	Pathway List
SEC11C	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; integral to membrane;
PSMD7	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
PSMB7	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
RPS9	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
RPL14	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
SPCS2	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; integral to membrane;
UBB	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
RPS2	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
PSMD5	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
RPL13	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
RPL27A	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
RPS10	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
UBC	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
PSMC3	5	gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
SRPR	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; integral to membrane;
RPS3	5	gene expression; translation; cellular protein metabolic process; SRP-dependent cotranslational protein targeting to membrane; protein binding;
PDIA3	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; cellular protein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;
TAPBP	5	antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; integral to membrane; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; protein binding;

Genes shared at least 2 KEGG pathways with SEC61B (count: 0)

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Region: chr9:101984346..101992897 View in gBrowse