ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SRPR
Symbol Alias	SRP-alpha, Sralpha
Approved Name	signal recognition particle receptor (docking protein)
Previous Name	signal recognition particle receptor ('docking protein')
Location	11q24-q25
Position	chr11:126132814-126139039, -
External Links	HGNC: 11307 Entrez Gene: 6734 Ensembl: ENSG00000182934 UCSC: uc001qdh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process		16
GO:0016021	integral to membrane	Cellular Component	TAS[2827661]	845
GO:0010467	gene expression	Biological Process		140
GO:0006987	activation of signaling protein activity involved in unfolded protein response	Biological Process		13
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process		18
GO:0006412	translation	Biological Process		42
GO:0006613	cotranslational protein targeting to membrane	Biological Process	TAS[2827661]	3
GO:0005785	signal recognition particle receptor complex	Cellular Component		1
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0005525	GTP binding	Molecular Function		53
GO:0005783	endoplasmic reticulum	Cellular Component	TAS[2827661]	100
GO:0003924	GTPase activity	Molecular Function		41
GO:0005047	signal recognition particle binding	Molecular Function		1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03060	Protein export	7	The protein export is the active transport of proteins from ...... The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role. More...

Genes shared at least 5 GO terms with SRPR (count: 6)

Gene Symbol	Pathway Count	Pathway List
SEC11C	6	cellular protein metabolic process; integral to membrane; gene expression; SRP-dependent cotranslational protein targeting to membrane; translation; endoplasmic reticulum membrane;
SPCS2	6	cellular protein metabolic process; integral to membrane; gene expression; SRP-dependent cotranslational protein targeting to membrane; translation; endoplasmic reticulum membrane;
SEC61B	5	cellular protein metabolic process; integral to membrane; gene expression; SRP-dependent cotranslational protein targeting to membrane; translation;
SRP19	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; translation; cotranslational protein targeting to membrane;
SYVN1	5	endoplasmic reticulum unfolded protein response; integral to membrane; activation of signaling protein activity involved in unfolded protein response; endoplasmic reticulum membrane; endoplasmic reticulum;
ATL3	5	integral to membrane; endoplasmic reticulum membrane; GTP binding; endoplasmic reticulum; GTPase activity;

Genes shared at least 2 KEGG pathways with SRPR (count: 0)

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Region: chr11:126132814..126139039 View in gBrowse