ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SYVN1
Symbol Alias	HRD1
Approved Name	synovial apoptosis inhibitor 1, synoviolin
Location	11q13
Position	chr11:64889252-64902004, -
External Links	HGNC: 20738 Entrez Gene: 84447 Ensembl: ENSG00000162298 UCSC: uc001odb.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 15)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 15)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0001701	in utero embryonic development	Biological Process		32
GO:0005515	protein binding	Molecular Function	IPI[18264092]	910
GO:0005634	nucleus	Cellular Component		770
GO:0005730	nucleolus	Cellular Component		243
GO:0005783	endoplasmic reticulum	Cellular Component		100
GO:0005789	endoplasmic reticulum membrane	Cellular Component		140
GO:0006987	activation of signaling protein activity involved in unfolded protein response	Biological Process		13
GO:0008270	zinc ion binding	Molecular Function		323
GO:0016021	integral to membrane	Cellular Component		845
GO:0016567	protein ubiquitination	Biological Process		41
GO:0016881	acid-amino acid ligase activity	Molecular Function	IDA[12459480]	1
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0030433	ER-associated protein catabolic process	Biological Process	IDA[12459480]	7
GO:0030968	endoplasmic reticulum unfolded protein response	Biological Process		16

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04120	Ubiquitin mediated proteolysis	29	Protein ubiquitination plays an important role in eukaryotic...... Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates. More...
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with SYVN1 (count: 17)

Gene Symbol	Pathway Count	Pathway List
HSPA5	8	negative regulation of apoptotic process; protein binding; nucleus; endoplasmic reticulum; endoplasmic reticulum membrane; activation of signaling protein activity involved in unfolded protein response; ER-associated protein catabolic process; endoplasmic reticulum unfolded protein response;
ATF6	6	protein binding; nucleus; endoplasmic reticulum membrane; activation of signaling protein activity involved in unfolded protein response; integral to membrane; endoplasmic reticulum unfolded protein response;
BARD1	5	negative regulation of apoptotic process; protein binding; nucleus; zinc ion binding; protein ubiquitination;
CBL	5	negative regulation of apoptotic process; protein binding; nucleus; zinc ion binding; protein ubiquitination;
GATA6	5	negative regulation of apoptotic process; in utero embryonic development; protein binding; nucleus; zinc ion binding;
KLHL20	5	negative regulation of apoptotic process; protein binding; nucleus; nucleolus; protein ubiquitination;
MALT1	5	negative regulation of apoptotic process; protein binding; nucleus; nucleolus; protein ubiquitination;
TRIM32	5	negative regulation of apoptotic process; protein binding; nucleus; zinc ion binding; protein ubiquitination;
HINFP	5	in utero embryonic development; protein binding; nucleus; nucleolus; zinc ion binding;
ALG2	5	protein binding; nucleus; endoplasmic reticulum membrane; integral to membrane; protein N-linked glycosylation via asparagine;
PDIA6	5	protein binding; endoplasmic reticulum; endoplasmic reticulum membrane; activation of signaling protein activity involved in unfolded protein response; endoplasmic reticulum unfolded protein response;
RCHY1	5	protein binding; nucleus; nucleolus; zinc ion binding; protein ubiquitination;
RFWD2	5	protein binding; nucleus; nucleolus; zinc ion binding; protein ubiquitination;
SREBF1	5	protein binding; nucleus; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane;
TRIM13	5	protein binding; endoplasmic reticulum membrane; zinc ion binding; integral to membrane; ER-associated protein catabolic process;
YIF1A	5	protein binding; endoplasmic reticulum membrane; activation of signaling protein activity involved in unfolded protein response; integral to membrane; endoplasmic reticulum unfolded protein response;
SRPR	5	endoplasmic reticulum; endoplasmic reticulum membrane; activation of signaling protein activity involved in unfolded protein response; integral to membrane; endoplasmic reticulum unfolded protein response;

Genes shared at least 2 KEGG pathways with SYVN1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
PARK2	2	Ubiquitin mediated proteolysis; Protein processing in endoplasmic reticulum;

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Region: chr11:64889252..64902004 View in gBrowse