ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	SRP19
Approved Name	signal recognition particle 19kDa
Previous Name	signal recognition particle 19kD
Location	5q21-q22
Position	chr5:112196885-112228776, +
External Links	HGNC: 11300 Entrez Gene: 6728 Ensembl: ENSG00000153037 UCSC: uc003kqc.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 31)

Literature-origin SNPs (count: 0)

LD-proxies (count: 31)

rs_ID	Location	Functional Annotation
rs2545167	Chr5:112213071(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs580237	Chr5:112194032(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant
rs368575	Chr5:112204896(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs818425	Chr5:112226655(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs460832	Chr5:112225148(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs430665	Chr5:112228667(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant
rs712665	Chr5:112227799(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant; non_coding_exon_variant
rs465454	Chr5:112230331(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs519397	Chr5:112229688(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs461866	Chr5:112231450(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs455412	Chr5:112224389(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs456313	Chr5:112224952(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs712662	Chr5:112222694(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs458451	Chr5:112224331(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1069061	Chr5:112218982(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs818427	Chr5:112221869(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs1093611	Chr5:112218476(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs1093677	Chr5:112218700(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs2545166	Chr5:112213805(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs419632	Chr5:112216389(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs382260	Chr5:112210344(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs9011	Chr5:112212608(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs463229	Chr5:112201284(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs7213	Chr5:112203564(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs351769	Chr5:112199974(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs495794	Chr5:112201094(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs351770	Chr5:112199199(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs372492	Chr5:112198015(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs431287	Chr5:112197986(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs712668	Chr5:112197637(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant
rs429427	Chr5:112194693(Fwd)	NMD_transcript_variant; intron_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005737	cytoplasm	Cellular Component		690
GO:0005730	nucleolus	Cellular Component	IDA[10618370]	243
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	Cellular Component	IDA[18089836]	1
GO:0005739	mitochondrion	Cellular Component		183
GO:0005634	nucleus	Cellular Component		770
GO:0042493	response to drug	Biological Process	IDA[18089836]	68
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0008312	7S RNA binding	Molecular Function	IDA[17434535]	1
GO:0010467	gene expression	Biological Process		140
GO:0006613	cotranslational protein targeting to membrane	Biological Process	TAS[1678319]	3
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	Biological Process		18
GO:0005829	cytosol	Cellular Component		447
GO:0006412	translation	Biological Process		42

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03060	Protein export	7	The protein export is the active transport of proteins from ...... The protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the general protein export system that transports newly synthesized proteins into or across the cell membrane. The translocation channel is formed from a conserved trimeric membrane protein complex, called the Sec61/SecY complex. The twin-arginine translocation (Tat) pathway is another protein transport system that transports folded proteins in bacteria, archaea, and chloroplasts. Many Tat systems comprise three functionally different membrane proteins, TatA, TatB, and TatC, but TatA and TatE seem to have overlapping functions, with TatA having by far the more important role. More...

Genes shared at least 5 GO terms with SRP19 (count: 26)

Gene Symbol	Pathway Count	Pathway List
RPL35	7	cytoplasm; nucleolus; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPS15A	7	cytoplasm; mitochondrion; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPS25	7	cytoplasm; nucleolus; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPS3	7	cytoplasm; nucleus; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPS9	7	cytoplasm; nucleolus; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
DCPS	6	cytoplasm; nucleolus; mitochondrion; nucleus; gene expression; cytosol;
RPL14	6	cytoplasm; cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
EIF2B1	5	cytoplasm; cellular protein metabolic process; gene expression; cytosol; translation;
GSK3B	5	cytoplasm; nucleolus; nucleus; response to drug; cytosol;
IARS	5	cytoplasm; nucleolus; nucleus; gene expression; cytosol;
KARS	5	cytoplasm; mitochondrion; nucleus; gene expression; cytosol;
MAPK1	5	cytoplasm; nucleolus; mitochondrion; nucleus; cytosol;
MEN1	5	cytoplasm; nucleolus; nucleus; gene expression; cytosol;
SARS	5	cytoplasm; mitochondrion; gene expression; cytosol; translation;
SNCA	5	cytoplasm; mitochondrion; nucleus; response to drug; cytosol;
XPO1	5	cytoplasm; nucleolus; response to drug; gene expression; cytosol;
MAPK3	5	nucleolus; mitochondrion; nucleus; gene expression; cytosol;
EEF1D	5	nucleus; cellular protein metabolic process; gene expression; cytosol; translation;
FAU	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPL12	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPL13	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPL37	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPL37A	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPL38	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
RPS12	5	cellular protein metabolic process; gene expression; SRP-dependent cotranslational protein targeting to membrane; cytosol; translation;
SRPR	5	cellular protein metabolic process; gene expression; cotranslational protein targeting to membrane; SRP-dependent cotranslational protein targeting to membrane; translation;

Genes shared at least 2 KEGG pathways with SRP19 (count: 0)

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Region: chr5:112196885..112228776 View in gBrowse