ADHDgene Database
  • Published Variant
  • Published Gene: 359
  • Published Region: 128
  • Pathway by PBA: 8
  • Study: 361

GO Report

Basic Info
ID GO:0042493
Name response to drug
Type biological process
No. of Genes in ADHDgene  73
Source Pathway by Database Search

PBA Result (with statistical significance of FDR<0.05)

GO related genes in ADHDgene (count: 73)

Literature-origin genes (count: 24)

Approved Symbol Approved Name Location No. of Studies (significant/non-significant/trend) Evidence[PMID]
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Xq23 5(2/3/0) IDA[18703043]
GSK3B glycogen synthase kinase 3 beta 3q13.3 1(1/0/0) IEA
DRD1 dopamine receptor D1 5q34-q35 8(5/3/0) ISS
NGF nerve growth factor (beta polypeptide) 1p13.1 2(2/0/0) IEA
DRD2 dopamine receptor D2 11q22-q23 10(3/7/0) ISS
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 16q13 1(0/1/0) IEA
MMP7 matrix metallopeptidase 7 (matrilysin, uterine) 11q21-q22 1(0/0/1) IEA
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 13q14-q21 13(7/6/0) IDA[15862800]
ADRA1A adrenoceptor alpha 1A 8p21.2 3(2/1/0) ISS
IL1RN interleukin 1 receptor antagonist 2q14.2 2(1/1/0) IEA
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 16p13.2 4(1/3/0) IEA
DRD3 dopamine receptor D3 3q13.3 8(1/7/0) ISS
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1p36-p35 2(0/2/0) IEA
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 6q13 14(5/9/0) IEA
NPPC natriuretic peptide C 2q37.1 1(0/1/0) IEA
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 5p13 2(1/1/0) IEA
MAOB monoamine oxidase B Xp11.4-p11.3 6(2/4/0) IEA
XPO1 exportin 1 2p15 1(0/0/1) IEA
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 5p15.3 70(43/26/1) IEA
OXTR oxytocin receptor 3p25 1(0/1/0) IEA
LPL lipoprotein lipase 8p22 1(0/0/1) IEA
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 17q11.2 26(13/13/0) IEA
COMT catechol-O-methyltransferase 22q11.21 29(7/22/0) IEA
SNCA synuclein, alpha (non A4 component of amyloid precursor) 4q21.3-q22 1(0/1/0) IEA

Genes from other sources Help (count: 49)

Approved Symbol Approved Name Source Evidence[PMID]
ADAM17 ADAM metallopeptidase domain 17 Mapped by significant region ISS[10433800]
EI24 etoposide induced 2.4 Mapped by significant region IEA
GSTT1 glutathione S-transferase theta 1 Mapped by CNV IEA
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mapped by CNV; Mapped by significant region TAS[1360704]
VEGFB vascular endothelial growth factor B Mapped by significant region IEA
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal Mapped by CNV; Mapped by PBA pathway IEA
OXCT1 3-oxoacid CoA transferase 1 Mapped by significant region IEA
AACS acetoacetyl-CoA synthetase Mapped by CNV IEA
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Mapped by LD-proxy IEA
ATG5 autophagy related 5 Mapped by CNV IEA
SRP19 signal recognition particle 19kDa Mapped by LD-proxy IDA[18089836]
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) Mapped by significant region IEA
ADORA2A adenosine A2a receptor Mapped by CNV IEA
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 Mapped by LD-proxy IEA
SS18 synovial sarcoma translocation, chromosome 18 Mapped by significant region IEA
IGFBP2 insulin-like growth factor binding protein 2, 36kDa Mapped by significant region IEA
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A Mapped by significant region IEA
WFDC1 WAP four-disulfide core domain 1 Mapped by CNV; Mapped by significant region IEA
BLMH bleomycin hydrolase Mapped by LD-proxy; Mapped by CNV IEA
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 Mapped by CNV IEA
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 Mapped by CNV; Mapped by significant region TAS[8912525]
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 Mapped by significant region IEA
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 Mapped by significant region TAS[8706931]
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 Mapped by significant region IDA[12024214]
APOC3 apolipoprotein C-III Mapped by significant region IEA
NCF2 neutrophil cytosolic factor 2 Mapped by significant region IEA
NNMT nicotinamide N-methyltransferase Mapped by significant region IEA
ABAT 4-aminobutyrate aminotransferase Mapped by significant region IEA
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) Mapped by significant region IEA
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 Mapped by CNV TAS[9861027]
INPPL1 inositol polyphosphate phosphatase-like 1 Mapped by significant region IEA
FOSL1 FOS-like antigen 1 Mapped by significant region IEA
SREBF1 sterol regulatory element binding transcription factor 1 Mapped by significant region IEA
TJP1 tight junction protein 1 Mapped by CNV; Mapped by significant region IEA
RAB6C RAB6C, member RAS oncogene family Mapped by significant region IDA[11054569]
BAD BCL2-associated agonist of cell death Mapped by significant region IEA
CCND1 cyclin D1 Mapped by significant region IEP[18291362]
CYBA cytochrome b-245, alpha polypeptide Mapped by significant region IEA
ARG1 arginase 1 Mapped by significant region IEA
IL6 interleukin 6 (interferon, beta 2) Mapped by significant region IEA
CPT1A carnitine palmitoyltransferase 1A (liver) Mapped by CNV; Mapped by significant region IEA
MVP major vault protein Mapped by CNV TAS[7585126]
APOA1 apolipoprotein A-I Mapped by significant region IEA
PAPD7 PAP associated domain containing 7 Mapped by significant region IDA[10066793]
GATA6 GATA binding protein 6 Mapped by significant region IMP[18671946]
GAL galanin/GMAP prepropeptide Mapped by CNV; Mapped by significant region IEA
NPC1 Niemann-Pick disease, type C1 Mapped by significant region IEA
MAPK9 mitogen-activated protein kinase 9 Mapped by CNV IEA
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 Mapped by CNV; Mapped by significant region IEA