ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	PSMD7
Symbol Alias	S12, P40, MOV34, Rpn8
Approved Name	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
Previous Name	"proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 (Mov34 homolog)"
Name Alias	"Mov34 homolog"
Location	16q22.3
Position	chr16:74330673-74340186, 1
External Links	HGNC: 9565 Entrez Gene: 5713 Ensembl: ENSG00000103035 UCSC: uc002fcq.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	biological process	TAS	14
GO:0000075	cell cycle checkpoint	biological process	TAS	21
GO:0042981	regulation of apoptotic process	biological process	TAS	34
GO:0016071	mRNA metabolic process	biological process	TAS	41
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	biological process	TAS	10
GO:0016070	RNA metabolic process	biological process	TAS	54
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0010467	gene expression	biological process	TAS	154
GO:0005654	nucleoplasm	cellular component	TAS	210
GO:0005515	protein binding	molecular function	IPI	1015
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	14
GO:0005829	cytosol	cellular component	TAS	485
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	18
GO:0000084	S phase of mitotic cell cycle	biological process	TAS	19
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	14
GO:0005838	proteasome regulatory particle	cellular component	TAS[7755639]	1
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	12
GO:0000502	proteasome complex	cellular component	TAS[8811196]	14
GO:0000082	G1/S transition of mitotic cell cycle	biological process	TAS	27
GO:0000278	mitotic cell cycle	biological process	TAS	66
GO:0016032	viral reproduction	biological process	TAS	66
GO:0000209	protein polyubiquitination	biological process	TAS	26
GO:0044281	small molecule metabolic process	biological process	TAS	270
GO:0000216	M/G1 transition of mitotic cell cycle	biological process	TAS	12
GO:0006521	regulation of cellular amino acid metabolic process	biological process	TAS	9
GO:0034641	cellular nitrogen compound metabolic process	biological process	TAS	30
GO:0006915	apoptotic process	biological process	TAS	127
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	biological process	TAS	10

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with PSMD7 (count: 63)

Gene Symbol	Pathway Count	Pathway List
PSMC3	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome complex; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSMB7	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome complex; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSMD5	27	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome complex; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSME1	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome complex; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSME2	26	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; proteasome complex; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
UBB	23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; M/G1 transition of mitotic cell cycle; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
UBC	23	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; nucleoplasm; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; M/G1 transition of mitotic cell cycle; apoptotic process; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
PSMA8	22	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of apoptotic process; mRNA metabolic process; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; RNA metabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; gene expression; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; S phase of mitotic cell cycle; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; viral reproduction; protein polyubiquitination; small molecule metabolic process; M/G1 transition of mitotic cell cycle; regulation of cellular amino acid metabolic process; cellular nitrogen compound metabolic process; apoptotic process;
CDC26	9	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; protein binding; cytosol; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
ANAPC4	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell cycle checkpoint; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; cytosol; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;
SKP2	8	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; nucleoplasm; protein binding; cytosol; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; protein polyubiquitination;
XPO1	8	mRNA metabolic process; RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol; mitotic cell cycle; viral reproduction;
PLK1	7	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; nucleoplasm; protein binding; cytosol; positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; mitotic cell cycle;
CDC45	7	cell cycle checkpoint; nucleoplasm; protein binding; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; M/G1 transition of mitotic cell cycle;
RPS2	7	mRNA metabolic process; RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol; viral reproduction;
NCBP1	7	mRNA metabolic process; RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol; viral reproduction;
CDT1	7	nucleoplasm; protein binding; cytosol; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; M/G1 transition of mitotic cell cycle;
RNPS1	6	mRNA metabolic process; RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
RPL13	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
RPS9	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
RPL27A	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
RPL14	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
RPS10	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
RPS3	6	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol; viral reproduction;
CCND1	6	nucleoplasm; protein binding; cytosol; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle;
RRM2	6	nucleoplasm; protein binding; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle; small molecule metabolic process;
SMC1A	5	cell cycle checkpoint; gene expression; nucleoplasm; protein binding; mitotic cell cycle;
RPL38	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
LSM4	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
HSPA8	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
SMG1	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
FAU	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RPL37A	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RPS25	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RPL12	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RPS12	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
DCPS	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
PATL1	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
RPL35	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RPS15A	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
RQCD1	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
DDX6	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
RPL37	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
PAIP1	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
SMG7	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
RPL3L	5	mRNA metabolic process; RNA metabolic process; gene expression; cytosol; viral reproduction;
PARN	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
CNOT6	5	mRNA metabolic process; RNA metabolic process; gene expression; protein binding; cytosol;
SNRPB	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
SNRPD3	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
SNRPD1	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
SNRPG	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
GEMIN2	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
SNRPD2	5	RNA metabolic process; gene expression; nucleoplasm; protein binding; cytosol;
SEC61B	5	gene expression; protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
RAN	5	gene expression; nucleoplasm; protein binding; cytosol; viral reproduction;
TCEB2	5	gene expression; nucleoplasm; protein binding; cytosol; viral reproduction;
MAPK3	5	gene expression; nucleoplasm; protein binding; cytosol; apoptotic process;
TCEB1	5	gene expression; nucleoplasm; protein binding; cytosol; viral reproduction;
POLA2	5	nucleoplasm; S phase of mitotic cell cycle; G1/S transition of mitotic cell cycle; mitotic cell cycle; M/G1 transition of mitotic cell cycle;
DHFRP1	5	nucleoplasm; cytosol; G1/S transition of mitotic cell cycle; mitotic cell cycle; small molecule metabolic process;
NCF2	5	protein binding; antigen processing and presentation of exogenous peptide antigen via MHC class I; cytosol; antigen processing and presentation of peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent;
NUP160	5	protein binding; cytosol; mitotic cell cycle; viral reproduction; small molecule metabolic process;

Genes shared at least 2 KEGG pathways with PSMD7 (count: 0)

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Region: chr16:74330673..74340186 View in gBrowse